An outline of endocrine disrupting chemicals and the influencing hormones: what the human society ought to know?

  • KAMALAKUMAR UTHAYANAN Intern Pharm.D, Department of Pharmacy Practice, J.K.K. Nattraja College of Pharmacy, Tamilnadu, India.
  • Seshadhri Sundareswaran Assistant Professor, Department of Pharmacy Practice, J.K.K. Nattraja College of Pharmacy, Tamilnadu, India.

Abstract

Endocrine-disrupting chemicals (EDCs) are exogenous chemicals that interfere with hormones action, thereby increasing the risk of adverse health outcomes, including cancer, reproductive impairment, cognitive deficits and obesity. A complex literature of mechanistic studies provides evidence on the hazards of EDC exposure, yet there is no widely accepted systematic method to integrate these data to help identify EDC hazards. Significant advances in research into endocrine-disrupting chemicals (EDCs) and their health effects have elevated concerns in recent years about these chemicals among a number of international scientific and health organizations. The research reviewed here provides knowledge about EDC’s that health scientists can use to inform their research and decision-making processes.


Keywords: Endocrine disrupting chemicals, hormones action, cancer, reproductive impairment, cognitive deficits and obesity

Keywords: Endocrine disrupting chemicals, hormones action, cancer, reproductive impairment, cognitive deficits, obesity

Downloads

Download data is not yet available.

Author Biographies

KAMALAKUMAR UTHAYANAN, Intern Pharm.D, Department of Pharmacy Practice, J.K.K. Nattraja College of Pharmacy, Tamilnadu, India.

Intern Pharm.D,  Department of Pharmacy Practice, J.K.K. Nattraja College of Pharmacy, Tamilnadu, India.

Seshadhri Sundareswaran, Assistant Professor, Department of Pharmacy Practice, J.K.K. Nattraja College of Pharmacy, Tamilnadu, India.

Assistant Professor, Department of Pharmacy Practice, J.K.K. Nattraja College of Pharmacy, Tamilnadu, India.

References

1) Ross, J., Waugh, A. and Wilson, K., 1996. Anatomy and physiology in health and illness Ross and Wilson anatomy and physiology in health and illness. 9th ed. New York: Churchill Livingstone, p.213.
2) World Health Organization. 2012. State of the Science of Endocrine-Disrupting Chemicals. Geneva: International Programme on Chemical Safety.
3) Zoeller RT, Brown TR, Doan LL, Gore AC, Skakkebaek NE, Soto AM, Woodruff TJ, Vom Saal FS. Endocrine-Disrupting Chemicals and Public Health Protection: A Statement of Principles from The Endocrine Society. Endocrinology 2012; 153:4097-4110. https://doi.org/10.1210/en.2012-1422
4) Casals-Casas C, Desvergne B. Endocrine disruptors: from endocrine to metabolic disruption. Annual Review of Physiology 2011; 73:135-162. https://doi.org/10.1146/annurev-physiol-012110-142200
5) Jenssen BM. Endocrine-disrupting chemicals and climate change: A worst-case combination for Arctic marine mammals and seabirds? Environmental Health Perspectives 2006; 114 (1):76-80. https://doi.org/10.1289/ehp.8057
6) Fingerhut M, Nelson DI, Driscoll T, Concha-Barrientos M, Steenland K, Punnett L, Pruss-Ustun A, Leigh J, Corvalan C, Eijkemans G, Takala J. The contribution of occupational risks to the global burden of disease: summary and next steps. La Medicina del lavoro 2006; 97:313-321.
7) World Health Organization. 2006. Preventing disease through healthy environments - towards an estimate of the environmental burden of disease. Geneva: World Health Organization.
8) Boyle CA, Boulet S, Schieve LA, Cohen RA, Blumberg SJ, Yeargin-Allsopp M, Visser S, Kogan MD. Trends in the prevalence of developmental disabilities in US children, 1997-2008. Pediatrics 2011; 127:1034-1042. https://doi.org/10.1542/peds.2010-2989
9) Gerona RR, Woodruff TJ, Dickenson CA, Pan J, Schwartz JM, Sen S, Friesen MW, Fujimoto VY, Hunt PA. Bisphenol-A (BPA), BPA glucuronide, and BPA sulfate in midgestation umbilical cord serum in a northern and central California population. Environmental science & technology 2013; 47:12477-12485. https://doi.org/10.1021/es402764d
10) Skakkebaek NE, Toppari J, Soder O, Gordon CM, Divall S, Draznin M. The exposure of fetuses and children to endocrine-disrupting chemicals: a European Society for Paediatric Endocrinology (ESPE) and Pediatric Endocrine Society (PES) call to action statement. Journal of Clinical Endocrinology and Metabolism 2011; 96:3056-3058. https://doi.org/10.1210/jc.2011-1269
11) Gore AC. Neuroendocrine targets of endocrine disruptors. Hormones. 2010; 9:16-27. https://doi.org/10.14310/horm.2002.1249
12) Sen A, Sellix MT. The circadian timing system and environmental circadian disruption: from follicles to fertility. Endocrinology. 2016; 157:3366-73. https://doi.org/10.1210/en.2016-1450
13) Harding AK, Daston GP, Boyd GR, Lucier GW, Safe SH, Stewart J, et al. Endocrine disrupting chemicals research program of the U.S. Environmental Protection Agency: summary of a peer-review report. Environmental Health Perspectives. 2006; 114:1276- 82. https://doi.org/10.1289/ehp.8875
14) Browne P, Noyes PD, Casey WM, Dix DJ. Application of adverse outcome pathways to U.S. EPA's endocrine disruptor screening program. Environmental Health Perspectives. 2017; 125:096001. https://doi.org/10.1289/EHP1304
15) Wohlfahrt-Veje C, Main KM, Skakkebaek NE. Testicular dysgenesis syndrome: foetal origin of adult reproductive problems. Clinical Endocrinology. 2009; 71:459-65. https://doi.org/10.1111/j.1365-2265.2009.03545.x
16) Minguez-Alarcon L, Gaskins AJ. Female exposure to endocrine disrupting chemicals and fecundity: a review. Current Opinion in Obstetrics and Gynecology. 2017; 29:202- 11. https://doi.org/10.1097/GCO.0000000000000373
17) Caserta D, Bordi G, Ciardo F, Marci R, La Rocca C, Tait S, et al. The influence of endocrine disruptors in a selected population of infertile women. Gynecological Endocrinology. 2013; 29:444-7. https://doi.org/10.3109/09513590.2012.758702
18) Harvey PW. Adrenocortical endocrine disruption. Journal of Steroid Biochemistry and Molecular Biology. 2016; 155(Pt. B):199-206. https://doi.org/10.1016/j.jsbmb.2014.10.009
19) Hampl R, Kubatova J, Starka L. Steroids and endocrine disruptors-history, recent state of art and open questions. Journal of Steroid Biochemistry and Molecular Biology. 2016; 155(Pt. B):217-23. https://doi.org/10.1016/j.jsbmb.2014.04.013
20) Martinez-Arguelles DB, Papadopoulos V. Mechanisms mediating environmental chemical-induced endocrine disruption in the adrenal gland. Front Endocrinology. 2015; 6:29. https://doi.org/10.3389/fendo.2015.00029
21) Kabir ER, Rahman MS, Rahman I. A review on endocrine disruptors and their possible impacts on human health. Environmental Toxicology and Pharmacology. 2015; 40:241-58. https://doi.org/10.1016/j.etap.2015.06.009
22) Braverman LE, He X, Pino S, Cross M, Magnani B, Lamm SH, et al. The effect of perchlorate, thiocyanate, and nitrate on thyroid function in workers exposed to perchlorate long-term. Journal of Clinical Endocrinology and Metabolism. 2005; 90:700-6.
https://doi.org/10.1210/jc.2004-1821
23) DiGangi J, Blum A, Bergman A, de Wit CA, Lucas D, Mortimer D, Schecter A, Scheringer M, Shaw SD, Webster TF. San Antonio Statement on brominated and chlorinated flame retardants. Environmental Health Perspectives. 2010; 118:A516-51. https://doi.org/10.1289/ehp.1003089
24) Stapleton HM, Sharma S, Getzinger G, Ferguson PL, Gabriel M, Webster TF, Blum A. Novel and High Volume Use Flame Retardants in US Couches Reflective of the 2005 PentaBDE Phase Out. Environmental Science & Technology. 2012; 46:13432-13439. https://doi.org/10.1021/es303471d
25) United Nations. Stockholm Convention on Persistent Organic Pollutants- Work programmes on new persistent organic pollutants. 2010;UNEP/POPS/COP.5/15.
Crossmark
Statistics
196 Views | 8 Downloads
How to Cite
1.
UTHAYANAN K, Sundareswaran S. An outline of endocrine disrupting chemicals and the influencing hormones: what the human society ought to know?. JDDT [Internet]. 15May2023 [cited 22Feb.2024];13(5):66-2. Available from: https://jddtonline.info/index.php/jddt/article/view/6062