Formulation and Evaluation of Gastroretentive Floating Microspheres of TRAMADOL HCl

  • Kishan Zodage Prof. Ravindra Nikam College of Pharmacy, Gondur, Dhule, Affiliated to Kavayitri Bahinabai Chaudhari North Maharashtra University, India.
  • Lokesh Gurav Prof. Ravindra Nikam College of Pharmacy, Gondur, Dhule, Affiliated to Kavayitri Bahinabai Chaudhari North Maharashtra University, India.
  • Sandip Ravandale Prof. Ravindra Nikam College of Pharmacy, Gondur, Dhule, Affiliated to Kavayitri Bahinabai Chaudhari North Maharashtra University, India.
  • Harshali Jadhav Prof. Ravindra Nikam College of Pharmacy, Gondur, Dhule, Affiliated to Kavayitri Bahinabai Chaudhari North Maharashtra University, India.
DOI https://doi.org/10.22270/jddt.v13i9.5956

Abstract

This study presents the formulation and evaluation of sustained-release microspheres containing Tramadol HCl. The aim was to achieve prolonged drug release for enhanced therapeutic efficacy and improved patient compliance. The microspheres were prepared using a solvent evaporation method with various combinations of polymers Agar and Pectin. The physical appearance, particle size, drug content, and moisture content were assessed for stability over time. Among the formulations, Batch F7 emerged as a standout candidate, displaying excellent buoyancy and sustained drug release characteristics. Comprehensive evaluations included in vitro drug release studies, kinetic data analysis, and stability assessments over 90 days. The study concludes that the combination of Agar and Pectin polymers in Batch F7 holds significant promise for achieving controlled drug release, suggesting its potential for advanced drug delivery systems.


Keywords: Gastroretentive Floating Microspheres, Tramadol HCl, prolonged drug release, patient compliance

Keywords: Gastroretentive Floating Microspheres, Tramadol HCl, prolonged drug release, patient compliance

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Author Biographies

Kishan Zodage, Prof. Ravindra Nikam College of Pharmacy, Gondur, Dhule, Affiliated to Kavayitri Bahinabai Chaudhari North Maharashtra University, India.

Prof. Ravindra Nikam College of Pharmacy, Gondur, Dhule, Affiliated to Kavayitri Bahinabai Chaudhari North Maharashtra University, India.

Lokesh Gurav, Prof. Ravindra Nikam College of Pharmacy, Gondur, Dhule, Affiliated to Kavayitri Bahinabai Chaudhari North Maharashtra University, India.

Prof. Ravindra Nikam College of Pharmacy, Gondur, Dhule, Affiliated to Kavayitri Bahinabai Chaudhari North Maharashtra University, India.

Sandip Ravandale, Prof. Ravindra Nikam College of Pharmacy, Gondur, Dhule, Affiliated to Kavayitri Bahinabai Chaudhari North Maharashtra University, India.

Prof. Ravindra Nikam College of Pharmacy, Gondur, Dhule, Affiliated to Kavayitri Bahinabai Chaudhari North Maharashtra University, India.

Harshali Jadhav, Prof. Ravindra Nikam College of Pharmacy, Gondur, Dhule, Affiliated to Kavayitri Bahinabai Chaudhari North Maharashtra University, India.

Prof. Ravindra Nikam College of Pharmacy, Gondur, Dhule, Affiliated to Kavayitri Bahinabai Chaudhari North Maharashtra University, India.

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1.
Zodage K, Gurav L, Ravandale S, Jadhav H. Formulation and Evaluation of Gastroretentive Floating Microspheres of TRAMADOL HCl. JDDT [Internet]. 15Sep.2023 [cited 2Oct.2023];13(9):70-7. Available from: https://jddtonline.info/index.php/jddt/article/view/5956
Issue
Vol 13 No 9 (2023): Volume 13, Issue 9, September 2023
Section
Research
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