Literature Review on the Therapeutic Potential of NAMPT in Brain Diseases
Abstract
Nicotinamide Phosphoribosyl transferase (NAMPT) is an important enzyme in the biosynthesis NAD+ and the byproduct nicotinamide mononucleotide (NMN) is also a vital intermediate in NAD+ synthesis. More importantly, the enzyme has been found to have therapeutic potential in the management and treatment of brain diseases such as stroke, depression, and cerebral ischemic injury. In this review, we looked critically at studies that have sought to explore the activities of NAMPT in the brain, the relevant pathways, the byproducts, and precursors of NAMPT with the hope to utilizing the knowledge gotten from the studies to project the possibility of utilizing the enzyme as a better way to treat brain diseases. The enzyme is projected to have a double-edged influence on cell processes and aging Likewise, it has neuroprotective advantages in neurons that express them. More scientific studies have shown that NAMPT is involved in the chain of activities involved in preventing depression. This review further elaborates on the therapeutic potentials of NAMPT, and also seeks to recommend further studies in this field to be carried out on a regular basis due to its promising potential.
Keywords: NAMPT; Brain; Therapeutic potential; Diseases; NAD; Cerebral ischemic injury, Stroke
Keywords:
NAMPT, Brain, Therapeutic potential, Diseases, NAD, Cerebral ischemic injury, StrokeDOI
https://doi.org/10.22270/jddt.v13i6.5854References
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