A Systemic review on Antioxidant Potential of Berries used in Imuuxanth by Renatus
Abstract
Food items which are plant based such as Berries, Vegetables and Fruit have significant effects on health, they pertain potential to boost up immune system. There have been researches and documents journaled supporting roles of phytochemicals extricated from berries in modulation of immune system. The primary phytochemicals in berry fruits are phenolic composites including flavonoids (anthocyanins, flavonols, flavones, flavanols, flavanones, and isoflavonoids), tannins, and phenolic acids. The presence of unequivocal Amount of polyphenols makes berries active against oxidative stresses (Antioxidant) and inflammation (Anti-inflammatory) in reverberations these berries show therapeutics such as Antidiabetics, Anticancerous, Anti-neurological muddles. This review examines berries which were used in imuuxanth formulation developed by Renatus Wellness: blackberries, blackcurrants, blueberries, cranberries, raspberries, black raspberries, and strawberries and their polyphenols having antioxidant potential Nevertheless, future clinical trials are required to study and improve the bioavailability of berries’ phenolic compounds and extend the evidence that the active compounds of berries can be used as medicinal foods against various diseases.
Keywords: Antioxidant, Berries, Imuuxanth, Renatus
Keywords:
Antioxidant, Berries, Immuxanth, RenatusDOI
https://doi.org/10.22270/jddt.v13i4.5802References
Oksana G, Wang CK. "Review of functional and pharmacological activities of berries." Molecules 2021; 26(13):3904. https://doi.org/10.3390/molecules26133904
Antioxidants-Implications, Olas B. Berry Phenolic. "for Human Health." Front. Pharmacol 2018; 9:78.
Manganaris, GA., Vlasios G, Ariel RV, and Leon AT. "Berry antioxidants: small fruits providing large benefits." Journal of the Science of Food and Agriculture 2014; 94(5):825-833. https://doi.org/10.1002/jsfa.6432
Nile SH, and Se WP. "Edible berries: Bioactive components and their effect on human health." Nutrition 2014; 30(2):134-144..
https://doi.org/10.1016/j.nut.2013.04.007
Krikorian, Robert, Marcelle D. Shidler, TA NASH, W. KALT, and SHUkITT-HALE VINQVIST-TYmCHUk mR. "B AND JOSEPH JA." Blueberry supplementation improves memory in older adults J Agric Food Chem 2010; 58(7):3996-4000. https://doi.org/10.1021/jf9029332
Singh B, Singh JP, Kaur A, and Singh N. "Phenolic compounds as beneficial phytochemicals in pomegranate (Punica granatum L.) peel: A review." Food chemistry 2018; 261:75-86. https://doi.org/10.1016/j.foodchem.2018.04.039
Abdul‐Lateef M, Liu Z, Plimmer G. "Evaluation of the effect of blackcurrant products on gut microbiota and on markers of risk for colon cancer in humans." Phytotherapy Research 2014; 28(3):416-422. https://doi.org/10.1002/ptr.5009
Lopez-Corona AV, Illeen VE, Fabio AGS, Angélica LSL, Luis EGA, and Rebeca GV. "Antioxidant, Anti-Inflammatory and Cytotoxic Activity of Phenolic Compound Family Extracted from Raspberries (Rubus idaeus): A General Review." Antioxidants 2022; 11(6):1192. https://doi.org/10.3390/antiox11061192
Shokoh P, Kharazi AZ, Bakhsheshi-Rad HR, Nur H, Ismail AF, Sharif S, RamaKrishna S, and Berto F. "Antioxidant, antimicrobial and antiviral properties of herbal materials." Antioxidants 2020; 9(12):1309. https://doi.org/10.3390/antiox9121309
Yang B, Yixin D, Fei W, and Yu Z. "Nanoformulations to enhance the bioavailability and physiological functions of polyphenols." Molecules 2020; 25(20):4613. https://doi.org/10.3390/molecules25204613
Warren ND., Rebecca GS, and Richard GS. "Performance of high tunnel tomato cultivars in northern New England." HortTechnology 2015; 25(1):139-146. https://doi.org/10.21273/HORTTECH.25.1.139
Mattioli, Roberto, Antonio Francioso, Luciana Mosca, and Paula Silva. "Anthocyanins: A comprehensive review of their chemical properties and health effects on cardiovascular and neurodegenerative diseases." Molecules 2020; 25(17):3809. https://doi.org/10.3390/molecules25173809
Alyssa F, Joye IJ. "Anthocyanins in whole grain cereals and their potential effect on health." Nutrients 2020; 12(10):2922 https://doi.org/10.3390/nu12102922
Lee SG, Terrence MV, Tae-Gyu N, Dae-Ok K, Sung IK, and Ock KC. "Contribution of anthocyanin composition to total antioxidant capacity of berries." Plant foods for human nutrition 2015; 70:427-432. https://doi.org/10.1007/s11130-015-0514-5
Jerome H, Solverson P, Zhu M, and Carbonero F. "The emerging role of dark berry polyphenols in human health and nutrition." Food Frontiers 2022; 3(1):3-27. https://doi.org/10.1002/fft2.128
. Okhale, S. E., J. O. Amupitan, I. G. Ndukwe, R. G. Ayo, P. O. Oladosu, and J. I. Okogun. "Synthesis and antibacterial activity of 7-deacetoxy-7α-hydroxygedunin." African Journal of Pure and Applied 2013; 7(4):157-163. https://doi.org/10.5897/AJPAC2013.0493
Kupe, Muhammed, Neva Karatas, Mehmet Settar Unal, Sezai Ercisli, Mojmir Baron, and Jiri Sochor. "Phenolic composition and antioxidant activity of peel, pulp and seed extracts of different clones of the Turkish grape cultivar 'Karaerik'." Plants 2021; 10(10):2154. https://doi.org/10.3390/plants10102154
Bryant, Bronwen, and Kathleen Knights. Pharmacology for Health Professionals ebook. Elsevier Health Sciences, 2014.
Costa, Samantha Serra, Josiane Dantas Viana, Carlos AntÃ&nio Borges Cohim Silva, Marcelo Andres Umsza-Guez, and Bruna Aparecida Souza Machado. "Phytochemical importance and utilization potential of grape residue from wine production." African Journal of Biotechnology 2017; 16(5):179-192. https://doi.org/10.5897/AJB2015.14954
Gupta, Madhavi, Sanjay Dey, Daphisha Marbaniang, Paulami Pal, Subhabrata Ray, and Bhaskar Mazumder. "Grape seed extract: Having a potential health benefits." Journal of food science and technology 2020; 57:1205-1215. https://doi.org/10.1007/s13197-019-04113-w
Sabitha M, Krishnaveni K, Murugan M, Basha AN, Pallan GA, Kandeepan C, Ramya S, Jayakumararaj R, In-silico ADMET predicated Pharmacoinformatics of Quercetin-3-Galactoside, polyphenolic compound from Azadirachta indica, a sacred tree from Hill Temple in Alagarkovil Reserve Forest, Eastern Ghats, India, Journal of Drug Delivery and Therapeutics, 2011; 11(5-S):77-84 https://doi.org/10.22270/jddt.v11i5-S.5026
Criste, Adriana, Adriana Cristina Urcan, Andrea Bunea, Flavia Roxana Pripon Furtuna, Neli Kinga Olah, Robert H. Madden, and Nicolae Corcionivoschi. "Phytochemical composition and biological activity of berries and leaves from four Romanian sea buckthorn (Hippophae rhamnoides L.) varieties." Molecules 2020; 25(5):1170. https://doi.org/10.3390/molecules25051170
Soorya C, Balamurugan S, Ramya S, Neethirajan K, Kandeepan C, Jayakumararaj R, Physicochemical, ADMET and Druggable properties of Myricetin: A Key Flavonoid in Syzygium cumini that regulates metabolic inflammations. Journal of Drug Delivery and Therapeutics, 2011; 11(4):66-73 https://doi.org/10.22270/jddt.v11i4.4890
Chen, Wending, Caiyun Xie, Qianqian He, Jianxia Sun, and Weibin Bai. "Improvement in color expression and antioxidant activity of strawberry juice fermented with lactic acid bacteria: A phenolic-based research." Food Chemistry: 2023; X17:100535. https://doi.org/10.1016/j.fochx.2022.100535
Alvarez-Suarez, José & Dekanski, Dragana & Ristić, Slavica & Radonjic, Nevena & Petronijevic, Natasa & Giampieri, Francesca & Astolfi, Paola & Gonzalez-paramas, Ana M. & Santos Buelga, Celestino & Tulipani, Sara & Quiles, José & Mezzetti, Bruno & Battino, Maurizio. . Strawberry Polyphenols Attenuate Ethanol-Induced Gastric Lesions in Rats by Activation of Antioxidant Enzymes and Attenuation of MDA Increase. PloS one. 2001; 6:e25878. https://doi.org/10.1371/journal.pone.0025878
Cao, Guohua, Robert M. Russell, Neal Lischner, and Ronald L. Prior. "Serum antioxidant capacity is increased by consumption of strawberries, spinach, red wine or vitamin C in elderly women." The Journal of nutrition 1998; 128(12):2383-2390. https://doi.org/10.1093/jn/128.12.2383
Frías-Moreno, María Noemí, Rafael A. Parra-Quezada, Gustavo González-Aguilar, Jacqueline Ruíz-Canizales, Francisco Javier Molina-Corral, David R. Sepulveda, Nora Salas-Salazar, and Guadalupe I. Olivas. "Quality, bioactive compounds, antioxidant capacity, and enzymes of raspberries at different maturity stages, effects of organic vs. Conventional fertilization." Foods 2021; 10(5):953. https://doi.org/10.3390/foods10050953
Bowen-Forbes, Camille S., Yanjun Zhang, and Muraleedharan G. Nair. "Anthocyanin content, antioxidant, anti-inflammatory and anticancer properties of blackberry and raspberry fruits." Journal of food composition and analysis 2010; 23(6):554-560. https://doi.org/10.1016/j.jfca.2009.08.012
Tulio Jr, Artemio Z., R. Neil Reese, Faith J. Wyzgoski, Peter L. Rinaldi, Ruiling Fu, Joseph C. Scheerens, and A. Raymond Miller. "Cyanidin 3-rutinoside and cyanidin 3-xylosylrutinoside as primary phenolic antioxidants in black raspberry." Journal of Agricultural and Food Chemistry 2008; 56(6):1880-1888. https://doi.org/10.1021/jf072313k
Tian, Qingguo, M. Monica Giusti, Gary D. Stoner, and Steven J. Schwartz. "Characterization of a new anthocyanin in black raspberries (Rubus occidentalis) by liquid chromatography electrospray ionization tandem mass spectrometry." Food Chemistry 2006; 94(3):465-468. https://doi.org/10.1016/j.foodchem.2005.01.020
Kaur, Charanjit, and Harish C. Kapoor. "Antioxidants in fruits and vegetables-the millennium's health." International journal of food science & technology 2001; 36(7):703-725. https://doi.org/10.1046/j.1365-2621.2001.00513.x
Diaconeasa, Zorița, Ioana Știrbu, Jianbo Xiao, Nicolae Leopold, Zayde Ayvaz, Corina Danciu, Huseyin Ayvaz, Andreea Stǎnilǎ, Mǎdǎlina Nistor, and Carmen Socaciu. "Anthocyanins, vibrant color pigments, and their role in skin cancer prevention." Biomedicines 2020; 8(9):336. https://doi.org/10.3390/biomedicines8090336
Pedersen, C. B., J. Kyle, AMcE Jenkinson, P. T. Gardner, D. B. McPhail, and G. G. Duthie. "Effects of blueberry and cranberry juice consumption on the plasma antioxidant capacity of healthy female volunteers." European journal of clinical nutrition 2000; 54(5):405-408. https://doi.org/10.1038/sj.ejcn.1600972
Kuntz, Sabine, Clemens Kunz, Johannes Herrmann, Christian H. Borsch, Georg Abel, Bettina Fröhling, Helmut Dietrich, and Silvia Rudloff. "Anthocyanins from fruit juices improve the antioxidant status of healthy young female volunteers without affecting anti-inflammatory parameters: results from the randomised, double-blind, placebo-controlled, cross-over ANTHONIA (ANTHOcyanins in Nutrition Investigation Alliance) study." British Journal of Nutrition 2014; 112(6):925-936. https://doi.org/10.1017/S0007114514001482
Zhao, Cuiwei, M. Monica Giusti, Minnie Malik, Mary P. Moyer, and Bernadene A. Magnuson. "Effects of commercial anthocyanin-rich extracts on colonic cancer and nontumorigenic colonic cell growth." Journal of Agricultural and food Chemistry 2004; 52(20):6122-6128. https://doi.org/10.1021/jf049517a
da Silva, Ives Charlie, Pedro Melillo de MagalhÃ, Ilza Maria de Oliveira Sousa, Mary Ann Foglio, Eduardo Leonardecz, and Ana Carolina de Souza Chagas. "Anthelmintic activity of Artemisia annua in sheep-model." Journal of Medicinal Plants Research 2017; 11(7):137-143. https://doi.org/10.5897/JMPR2016.6318
Zielinska, M., Piotr Sadowski, and Wioletta Błaszczak. "Freezing/thawing and microwave-assisted drying of blueberries (Vaccinium corymbosum L.)." LWT-Food Science and Technology 2015; 62(1):555-563. https://doi.org/10.1016/j.lwt.2014.08.002
Basu, Arpita, and Timothy J. Lyons. "Strawberries, blueberries, and cranberries in the metabolic syndrome: clinical perspectives." Journal of agricultural and food chemistry 2012; 60(23):5687-5692. https://doi.org/10.1021/jf203488k
Wolfe, Kelly L., Xinmei Kang, Xiangjiu He, Mei Dong, Qingyuan Zhang, and Rui Hai Liu. "Cellular antioxidant activity of common fruits." Journal of agricultural and food chemistry 2008; 56(18):8418-8426. https://doi.org/10.1021/jf801381y
Song, Wei, Christopher M. Derito, M. Keshu Liu, Xiangjiu He, Mei Dong, and Rui Hai Liu. "Cellular antioxidant activity of common vegetables." Journal of Agricultural and Food Chemistry 2010; 58(11):6621-6629. https://doi.org/10.1021/jf9035832
Kellett, Mary E., Phillip Greenspan, and Ronald B. Pegg. "Modification of the cellular antioxidant activity (CAA) assay to study phenolic antioxidants in a Caco-2 cell line." Food chemistry 2018; 244:359-363. https://doi.org/10.1016/j.foodchem.2017.10.035
Gülcin, Ilhami. "Antioxidant activity of food constituents: an overview." Archives of toxicology 2012; 86:345-391. https://doi.org/10.1007/s00204-011-0774-2
Scalzo, Jessica, Alessia Politi, Nicoletta Pellegrini, Bruno Mezzetti, and Maurizio Battino. "Plant genotype affects total antioxidant capacity and phenolic contents in fruit." Nutrition 2005; 21(2):207-213. https://doi.org/10.1016/j.nut.2004.03.025
Howell, A., W. Kalt, J. C. Duy, C. F. Forney, and J. E. McDonald. "Horticultural factors affecting antioxidant capacity of blueberries and other small fruit." HortTechnology 2001; 11(4):523-528. https://doi.org/10.21273/HORTTECH.11.4.523
Yoo, Kyung-Mi, Dae-Ok Kim, and Chang-Yong Lee. "Evaluation of different methods of antioxidant measurement." Food science and biotechnology 2007; 16(2):177-182.46. Olas, Beata. "Berry phenolic antioxidants-implications for human health?." Frontiers in pharmacology 2018; 9:78. https://doi.org/10.3389/fphar.2018.00078
Heinonen, Marina. "Antioxidant activity and antimicrobial effect of berry phenolics-a Finnish perspective." Molecular nutrition & food research 2007; 51(6):684-691. https://doi.org/10.1002/mnfr.200700006
Bagchi, Debasis, Sashwati Roy, Viren Patel, Guanglong He, Savita Khanna, Navdeep Ojha, Christina Phillips, Sumona Ghosh, Manashi Bagchi, and Chandan K. Sen. "Safety and whole-body antioxidant potential of a novel anthocyanin-rich formulation of edible berries." Molecular and cellular biochemistry 2006; 281:197-209. https://doi.org/10.1007/s11010-006-1030-6
Maya-Cano, Daniela A., Sandra Arango-Varela, and Gloria A. Santa-Gonzalez. "Phenolic compounds of blueberries (Vaccinium spp) as a protective strategy against skin cell damage induced by ROS: A review of antioxidant potential and antiproliferative capacity." Heliyon 2021; 7(2):e06297. https://doi.org/10.1016/j.heliyon.2021.e06297
Metzner Ungureanu, Cristina-Ramona, Mariana-Atena Poiana, Ileana Cocan, Andreea Ioana Lupitu, Ersilia Alexa, and Diana Moigradean. "Strategies to improve the thermo-oxidative stability of sunflower oil by exploiting the antioxidant potential of blueberries processing byproducts." Molecules 2020; 25(23):5688. https://doi.org/10.3390/molecules25235688
Kähkönen, Marja P., Anu I. Hopia, and Marina Heinonen. "Berry phenolics and their antioxidant activity." Journal of agricultural and food chemistry 2001; 49(8):4076-4082. https://doi.org/10.1021/jf010152t
Li, Wende, Arnold W. Hydamaka, Lynda Lowry, and Trust Beta. "Comparison of antioxidant capacity and phenolic compounds of berries, chokecherry and seabuckthorn." Central European Journal of Biology 2009; 4:499-506. https://doi.org/10.2478/s11535-009-0041-1
Duan, Xuewu, Genfu Wu, and Yueming Jiang. "Evaluation of the antioxidant properties of litchi fruit phenolics in relation to pericarp browning prevention." Molecules 2007; 12(4):759-771. https://doi.org/10.3390/12040759
de Mello Andrade, Juliana Maria, and Daniel Fasolo. "Polyphenol antioxidants from natural sources and contribution to health promotion." In Polyphenols in human health and disease, pp. 253-265. Academic Press, 2014. https://doi.org/10.1016/B978-0-12-398456-2.00020-7
Tulipani, Sara, Bruno Mezzetti, Franco Capocasa, Stefano Bompadre, Jules Beekwilder, CH Ric De Vos, Esra Capanoglu, Arnaud Bovy, and Maurizio Battino. "Antioxidants, phenolic compounds, and nutritional quality of different strawberry genotypes." Journal of Agricultural and Food chemistry 2008; 56(3):696-704. https://doi.org/10.1021/jf0719959
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