Floating Drug Delivery System: As A Novel Approach for Drug Delivery

  • Mahima Choudhary Department of Pharmacy, IEC College of Engineering and Technology, Greater Noida, Uttar Pradesh, India 201310
  • Chanchal Tiwari Department of Pharmacy, IEC College of Engineering and Technology, Greater Noida, Uttar Pradesh, India 201310
  • Rajeev Kumar Chahar Department of Pharmacy, IEC College of Engineering and Technology, Greater Noida, Uttar Pradesh, India 201310
  • Princy Malik Department of Pharmacy, IEC College of Engineering and Technology, Greater Noida, Uttar Pradesh, India 201310
  • PANKAJ KUMAR JAISWAL Department of Pharmacy, IEC College of Engineering and Technology, Greater Noida, Uttar Pradesh, India 201310
  • Reetu Chauhan Lords international college of pharmacy, Alwar Rajasthan, India, 301028

Abstract

The retention period of the drug and dosage form in the stomach is very challenging for the treatment of gastrointestinal disease. To solve this problem and improve the efficacy and bioavailability of the drug, most researchers develop a novel carrier system that is called a Floating drug delivery system (FDDS).  The goal of this review on floating drug delivery systems (FDDS) is to synthesise contemporary material with a particular concentration on the main mechanism of flotation for stomach retention. The physiology of the stomach (including gastric pH and movement) has been shown a major effect on gastrointestinal holding period and drug delivery behaviour in both intra- and inter-subject variability. The most recent advancements in the Floating drug delivery system (FDDS) are thoroughly reviewed, including the physiological and formulation factors that influence stomach retention, design methods for single-unit and multiple-unit floating systems, and their categorization and formulation characteristics. A synopsis of the research that has been done to determine the effectiveness and utility of floating systems, as well as uses for such systems, is also included in this review. This study covers the most recent Floating drug delivery system (FDDS) technology advances, including patented delivery techniques and commercial devices, along with their benefits and potential applications for oral controlled drug administration in the future.


Keywords: Floating drug delivery system, Gastric-emptying time, Inter-digestive myoelectric cycle (IDMC), Polymers, Bioavailability, Membrane permeability.

Keywords: Floating drug delivery system, Gastric-emptying time, Inter-digestive myoelectric cycle (IDMC), Polymers, Bioavailability, Membrane permeability

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Author Biographies

Mahima Choudhary, Department of Pharmacy, IEC College of Engineering and Technology, Greater Noida, Uttar Pradesh, India 201310

Department of Pharmacy, IEC College of Engineering and Technology, Greater Noida, Uttar Pradesh, India 201310

Chanchal Tiwari, Department of Pharmacy, IEC College of Engineering and Technology, Greater Noida, Uttar Pradesh, India 201310

Department of Pharmacy, IEC College of Engineering and Technology, Greater Noida, Uttar Pradesh, India 201310

Rajeev Kumar Chahar, Department of Pharmacy, IEC College of Engineering and Technology, Greater Noida, Uttar Pradesh, India 201310

Department of Pharmacy, IEC College of Engineering and Technology, Greater Noida, Uttar Pradesh, India 201310

Princy Malik, Department of Pharmacy, IEC College of Engineering and Technology, Greater Noida, Uttar Pradesh, India 201310

Department of Pharmacy, IEC College of Engineering and Technology, Greater Noida, Uttar Pradesh, India 201310

PANKAJ KUMAR JAISWAL, Department of Pharmacy, IEC College of Engineering and Technology, Greater Noida, Uttar Pradesh, India 201310

Department of Pharmacy, IEC College of Engineering and Technology, Greater Noida, Uttar Pradesh, India 201310

Reetu Chauhan, Lords international college of pharmacy, Alwar Rajasthan, India, 301028

Lords international college of pharmacy, Alwar Rajasthan, India, 301028

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Choudhary M, Tiwari C, Chahar RK, Malik P, JAISWAL P, Chauhan R. Floating Drug Delivery System: As A Novel Approach for Drug Delivery. JDDT [Internet]. 15Nov.2022 [cited 9Dec.2022];12(6):210-8. Available from: https://jddtonline.info/index.php/jddt/article/view/5778