Design and In-Vitro Evaluation of Compressed Kollidon® SR Based Naproxen Sodium Microcapsule: Effect of Talc

  • Reza-Ul Jalil Department of Pharmaceutical Technology, University of Dhaka, Dhaka-1000, Bangladesh
  • Jakir Ahmed Chowdhury Department of Pharmaceutical Technology, University of Dhaka, Dhaka-1000, Bangladesh
  • Fuad M Laman Department of Pharmacy, University of Asia Pacific, Dhanmondi, Dhaka-1209, Bangladesh

Abstract

Naproxen sodium is a nonsteroidal anti-inflammatory drug (NSAID) with analgesic antipyretic properties. In this research work, naproxen sodium was encapsulated by solvent-evaporation technique using kollidon® SR as coating polymeric material to prolong the therapeutic duration of the drug. Four different concentrations of talc were used as additives to see the changes in drug release pattern from the compressed microcapsules. Scanning Electron Microscopy (SEM) was applied to study size and surface morphology of prepared microcapsules. UV-spectrophotometric method was applied to calculate the drug loading efficiency and the performance of the prepared dosage form was evaluated in terms of in-vitro dissolution studies according to USP paddle method (type 2) in 400 ml in phosphate buffer (pH 6.8) for 8 hours at 370 ± 50 C temperature at 50 rpm. Release of naproxen sodium from the compressed microcapsules was found to follow hixon crowell mechanism (R2=0.99). Hixon equation was used to calculate the release exponent value (n) which indicates the drug release behavior and the mean dissolution time T50% (MDT) for release rate. The surfaces of the microcapsules became smoother with the increase in talc amount and simultaneously decrease in drug release rate.


Keywords: Naproxen sodium, Kollidon® SR, microcapsule, emulsion solvent evaporation technique, MDT (Mean Dissolution Time)  

Keywords: Naproxen sodium, Kollidon® SR, microcapsule, emulsion solvent evaporation technique, MDT (Mean Dissolution Time)

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Author Biographies

Reza-Ul Jalil, Department of Pharmaceutical Technology, University of Dhaka, Dhaka-1000, Bangladesh

Department of Pharmaceutical Technology, University of Dhaka, Dhaka-1000, Bangladesh

Jakir Ahmed Chowdhury, Department of Pharmaceutical Technology, University of Dhaka, Dhaka-1000, Bangladesh

Department of Pharmaceutical Technology, University of Dhaka, Dhaka-1000, Bangladesh

Fuad M Laman, Department of Pharmacy, University of Asia Pacific, Dhanmondi, Dhaka-1209, Bangladesh

Pharmaceutical Sciences, Long Island University, Brooklyn, New York 11201, USA

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Jalil R-U, Chowdhury JA, Laman FM. Design and In-Vitro Evaluation of Compressed Kollidon® SR Based Naproxen Sodium Microcapsule: Effect of Talc. JDDT [Internet]. 15Mar.2023 [cited 14Apr.2024];13(3):37-2. Available from: https://jddtonline.info/index.php/jddt/article/view/5752