Formulation Development and Evaluation of Nanoparticulate Systems of Levofloxacin
Nanoparticulate
Abstract
An emerging advancement in pharmaceutical sciences and perturbing limitation of conventional drug delivery systems have triggered extensive research in novel carrier systems. There has been extensive research on novel carriers that promise patient compliance, but toxicological part is still the biggest challenge to any drug delivery systems. In the present research, we have develop levofloxacin nanopartulate systems with chitosan and sodium triphosphte which offer safer dosage form with increased bioavailability as well as better patient compliance. In all formulation the minimum percentage yield shows in formulation F8 (70.23%) and maximum in formulation F6 (89.23%). The highest % cumulative drug release after 8 hrs was found to be 92.658 and first order release kinetics; the r2 value for first order was found to be 0.988
Keywords: Nanoparticulate systems, Chitosan, Levofloxacin, Compliance, Bioavailability.
Keywords:
Nanoparticulate systems, Chitosan, Levofloxacin, Compliance, BioavailabilityDOI
https://doi.org/10.22270/jddt.v12i5-S.5741References
De Jong WH, Borm PJ. Drug delivery and nanoparticles:applications and hazards. Int J Nanomedicine. 2008; 3(2):133-49 https://doi.org/10.2147/IJN.S596
Patel A, Patel M, Yang X, Mitra AK. Recent advances in protein and Peptide drug delivery: a special emphasis on polymeric nanoparticles. Protein Pept Lett. 2014; 21(11):1102-20 https://doi.org/10.2174/0929866521666140807114240
Ameeduzzafar, Khan N, Alruwaili NK, Bukhari SNA, Alsuwayt B, Afzal M, Akhter S, Yasir M, Elmowafy M, Shalaby K, Ali A. Improvement of Ocular Efficacy of Levofloxacin by Bioadhesive Chitosan Coated PLGA Nanoparticles: Box-behnken Design, In-vitro Characterization, Antibacterial Evaluation and Scintigraphy Study. Iran J Pharm Res. 2020 Winter; 19(1):292-311
Al-nemrawi, Nusaiba & Alsharif, Sara & Dave, Rutesh. Preparation of chitosan-tpp nanoparticles: The influence of chitosan polymeric properties and formulation variables. International Journal of Applied Pharmaceutics. 2018; 10:60. https://doi.org/10.22159/ijap.2018v10i5.26375
Agarwal, Megha & Agarwal, Mukesh & Shrivastav, Nalini & Pandey, Sarika & Das, Ritu & Gaur, Priyanka. Preparation of Chitosan Nanoparticles and their In-vitro Characterization. International Journal of Life-Sciences Scientific Research. 2018; 4:1713-1720. https://doi.org/10.21276/ijlssr.2018.4.2.17
Partha Saha , Amit K Goyal and Goutam Rath, Formulation and Evaluation of Chitosan-Based Ampicillin Trihydrate Nanoparticles Tropical Journal of Pharmaceutical Research October 2010; 9(5):483-488. https://doi.org/10.4314/tjpr.v9i5.61061
David, Mădălina Elena & Ion, Rodica-Mariana & Grigorescu, Hybrid Materials Based on Multi-Walled Carbon Nanotubes and Nanoparticles with Antimicrobial Properties. Nanomaterials. 2021; 11:1415. https://doi.org/10.3390/nano11061415
Friedrich RP, Kappes M, Cicha I, Tietze R, Braun C, Schneider-Stock R, Nagy R, Alexiou C, Janko C. Optical Microscopy Systems for the Detection of Unlabeled Nanoparticles. Int J Nanomedicine. 2022; 17:2139-2163. https://doi.org/10.2147/IJN.S355007
Jaikumar RA, Karthigeyan S, Bhat R, Naidu N, Natrajan S, Angamuthu V analysis of surface morphology and elemental composition on zirconia implant before and after photo functionalization by scanning electron microscopy and energy dispersive X-ray spectroscopy- An invitro study.J Pharm Bioall Sci.2021; 13Supply S1: 761-5 https://doi.org/10.4103/jpbs.JPBS_716_20
Maryam Kouchak, and Armita Azarpanah, Preparation and In Vitro Evaluation of Chitosan Nanoparticles Containing Diclofenac Using the Ion-Gelation Method Jundishapur J Nat Pharm Prod. 2015 May; 10(2):42-57. https://doi.org/10.17795/jjnpp-23082
Hutnik C, Mohammad-Shahi MH. Bacterial conjunctivitis. Clin Ophthalmol. 2010 Dec 6; 4:1451-7 https://doi.org/10.2147/OPTH.S10162
Llor C, Bjerrum L. Antimicrobial resistance: risk associated with antibiotic overuse and initiatives to reduce the problem. Ther Adv Drug Saf. 2014 Dec; 5(6):229-41. https://doi.org/10.1177/2042098614554919
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