Synthesis, Characterization, and Anti-inflammatory activity of Some Novel Oxazole Derivatives

Abstract

A series of novel oxazole derivatives (A, A1, A2) were synthesized starting from acetone and urea. The compound (A) was obtained by heating it with acetophenone and urea in iodine. Compound (A) on treatment with 4-amino benzaldehyde (Z)-N-(4-amino benzylidine)-4-((E)-Penta-2, 4-diene-2) oxazole-2-amine afforded (A1). Acylation of compound (A) with 4-amino benzoyl chloride to obtain the corresponding N-(4 phenyl oxazole-2- yl)- benzamide (A2). The structures of compounds have been established employing FTIR and 1H-NMR spectral analysis. All oxazole derivatives were evaluated for anti-inflammatory activity by the carrageenan-induced Rat hind paw method. Derivative A1 shows maximum anti-inflammatory activity.


Keywords: Oxazoles, anti-inflammatory, Benzamide, acetophenone, indomethacin.

Keywords: Oxazoles, anti-inflammatory, Benzamide, acetophenone, indomethacin

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Author Biographies

Ajay Kumar Garg, Department of Pharmaceutical Sciences, Raffles University, Japanese Zone, NH-8, Neemrana, Rajasthan-301020, India

Department of Pharmaceutical Sciences, Raffles University, Japanese Zone, NH-8, Neemrana, Rajasthan-301020, India

Ranjan Kumar Singh, Department of Pharmaceutical Sciences, Raffles University, Japanese Zone, NH-8, Neemrana, Rajasthan-301020, India

Department of Pharmaceutical Sciences, Raffles University, Japanese Zone, NH-8, Neemrana, Rajasthan-301020, India

Vaibhav Saxena, Department of Pharmaceutical Sciences, Regional College of Pharmacy, Sitapura, Jaipur, Rajasthan-302022, India

Department of Pharmaceutical Sciences, Regional College of Pharmacy, Sitapura, Jaipur, Rajasthan-302022, India

Saurabh Kr. Sinha, Department of Pharmaceutical Sciences, Mohanlal Sukhadia University, Udaipur, Rajasthan-313001, India

Department of Pharmaceutical Sciences, Mohanlal Sukhadia University, Udaipur, Rajasthan-313001, India

Sanjay Rao, Department of Pharmaceutical Sciences, Goenka College of Pharmacy, Sikar, Rajasthan-332315, India

Department of Pharmaceutical Sciences, Goenka College of Pharmacy, Sikar, Rajasthan-332315, India

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1.
Garg AK, Singh RK, Saxena V, Sinha SK, Rao S. Synthesis, Characterization, and Anti-inflammatory activity of Some Novel Oxazole Derivatives. JDDT [Internet]. 15Jan.2023 [cited 27Jan.2023];13(1):26-8. Available from: https://jddtonline.info/index.php/jddt/article/view/5719