In Vivo and In Vitro Animal Models for Ulcer: A Conscious Review

  • Mohd. Shahid Khan Research Scholar, Faculty of Pharmaceutical Sciences, Lords University, Alwar, Rajasthan
  • Pankaj Arora Professor, Faculty of Pharmaceutical Sciences, Lords University, Alwar, Rajasthan
  • Naresh Kalra Professor, Faculty of Pharmaceutical Sciences, Lords University, Alwar, Rajasthan
  • Namita Arora Professor, Faculty of Pharmaceutical Sciences, Lords University, Alwar, Rajasthan


An ulcer is definite as a disease that happens owing to subside of the epithelial mucosal wall of the stomach when unguarded to an additional of hydrochloric acid and pepsin enzyme. Research for a potential anti-ulcer agent involves appropriate in vitro or in vivo models. Due to their anatomical, physiological, and genetic similarities to humans, rodents like mice and rats are ideal among the various animal models. In vivo methods are usually applied, as the sickly condition in human being can be imitated with distinct animal prototypes. The in vitro methods have been not often used for investigation of anti-ulcer agents.

Keywords: Ulcer, Hydrochloric Acid, Anti-ulcer agents, Pepsin Enzyme

Keywords: Ulcer, Hydrochloric Acid, Anti-ulcer agents, Pepsin Enzyme


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Author Biographies

Mohd. Shahid Khan, Research Scholar, Faculty of Pharmaceutical Sciences, Lords University, Alwar, Rajasthan

Research Scholar, Faculty of Pharmaceutical Sciences, Lords University, Alwar, Rajasthan

Pankaj Arora, Professor, Faculty of Pharmaceutical Sciences, Lords University, Alwar, Rajasthan

Professor, Faculty of Pharmaceutical Sciences, Lords University, Alwar, Rajasthan

Naresh Kalra, Professor, Faculty of Pharmaceutical Sciences, Lords University, Alwar, Rajasthan

Professor, Faculty of Pharmaceutical Sciences, Lords University, Alwar, Rajasthan

Namita Arora, Professor, Faculty of Pharmaceutical Sciences, Lords University, Alwar, Rajasthan

Professor, Faculty of Pharmaceutical Sciences, Lords University, Alwar, Rajasthan


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Khan MS, Arora P, Kalra N, Arora N. In Vivo and In Vitro Animal Models for Ulcer: A Conscious Review. JDDT [Internet]. 15Nov.2022 [cited 1Dec.2023];12(6):227-31. Available from: