In Vivo and In Vitro Animal Models for Ulcer: A Conscious Review
Abstract
An ulcer is definite as a disease that happens owing to subside of the epithelial mucosal wall of the stomach when unguarded to an additional of hydrochloric acid and pepsin enzyme. Research for a potential anti-ulcer agent involves appropriate in vitro or in vivo models. Due to their anatomical, physiological, and genetic similarities to humans, rodents like mice and rats are ideal among the various animal models. In vivo methods are usually applied, as the sickly condition in human being can be imitated with distinct animal prototypes. The in vitro methods have been not often used for investigation of anti-ulcer agents.
Keywords: Ulcer, Hydrochloric Acid, Anti-ulcer agents, Pepsin Enzyme
Keywords:
Ulcer, Hydrochloric Acid, Anti-ulcer agents, Pepsin Enzyme
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References
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5. Alkofahi A, Atta AH. Pharmacological screening of the anti-ulcerogenic effects of some Jordanian medicinal plants in rats. J Ethnopharmacol. 1999; 67:341-5p. https://doi.org/10.1016/S0378-8741(98)00126-3
6. Susser M. Causes of peptic ulcer: A selective epidemiologic review. J Chronic Dis. 1967; 20(6):435-56p. https://doi.org/10.1016/0021-9681(67)90015-X
7. Bonnevie O. Changing Demographies of Peptic Ulcer Disease. Digest Dis Sci. 1985; 30(11):85-145p. https://doi.org/10.1007/BF01309380
8. Fang B, Yang S, Liu H, et al. Association between depression and subsequent peptic ulcer occurrence among older people living alone: A prospective study investigating the role of change in social engagement. J Psychosom Res. 2019; 122:94-103p. https://doi.org/10.1016/j.jpsychores.2019.04.002
9. Friedman GD, Siegelaub AB, Seltzer CC. Cigarettes, Alcohol, Coffee and Peptic Ulcer. N Engl J Med. 1974; 290 (9):469-73p. https://doi.org/10.1056/NEJM197402282900901
10. Kavitt RT, Lipowska AM, Anyane-Yeboa A, et al. Diagnosis and Treatment of Peptic Ulcer Disease. Am J Med. 2019; 132(4):447-56p. https://doi.org/10.1016/j.amjmed.2018.12.009
11. Amtul M, Mohammed A, Syed H et al. Anti-Ulcer activity of medicinal plants: A review. Int. J. Pharm. Sci. Rev. 2019; 17:96-102.
12. Ramasubramaniaraja R, Babu M N, Peptic ulcer and phytochemistry: an overview, Journal of Pharmacy Research, 2011; 4:156-160.
13. Dong SXM, Chang CCY, Rowe KJ. A collection of the etiological theories, characteristics, and observations/ phenomena of peptic ulcers in existing data. Data Brief. 2018; 19: 1058-67p. 10. https://doi.org/10.1016/j.dib.2018.05.022
14. Vesely KT, Kubickkova Z, Dvorakova M, Zvolankova K. Clinical data and characteristics differentiating types of peptic ulcer. Br Med J. 1968; 9:57-68. https://doi.org/10.1136/gut.9.1.57
15. Johnson HD. Gastric Ulcer: Classification, Blood Group Characteristics, Secretion Patterns and Pathogenesis. Ann Surg. 1964; 162(6):996-1004. https://doi.org/10.1097/00000658-196512000-00005
16. Zheng H, Shah PK, Audus KL. Primary Culture of Rat Gastric Epithelial Cells as an in vitro model to Evaluate Antiulcer Agents. Pharm Res. 1994; 11(1):77-78. https://doi.org/10.1023/A:1018997711710
17. Goineau S, Castagne V. Complementarity of in vitro and in vivo models for the evaluation of gastroprotective effects of pharmacological substances. Fund Clin Pharmacol. 2016; 31(2):155-164. https://doi.org/10.1111/fcp.12248
18. Kondo S, Mizuno S, Hashita T, et al. Using human iPS cell-derived enterocytes as novel in vitro model for the evaluation of human intestinal mucosal damage. Inflamm Res. 2018; 67: 975-984. https://doi.org/10.1007/s00011-018-1193-0
19. Murakami K, Okajima K, Harada N, et al. Rebamipide prevents Indomethacin-induced gastric mucosal lesion formation by inhibiting activation of neutrophils in rats. Digest Dis Sci. 1998; 43(9): 139-142. https://doi.org/10.1016/S0016-5085(98)80960-8
20. Takahashi K, Okabe S. The cytoprotective effect of leminoprazole on Indomethacin- induced damage to rabbit gastric mucosal cells. J Pharmacol Exp Ther. 1996; 279(2): 975-182.
21. Joh T, Takezono Y, Oshima T, et al. The protective effect of rebamipide on paracellular permeability of rat gastric epithelial cells. Aliment PharmTher. 2003; 18(1): 133-138. https://doi.org/10.1046/j.1365-2036.18.s1.15.x
22. Umre R, GaneshpurkarA, Ganeshpurkar A, et al. In vitro, in vivo and in silico antiulcer activity of ferulic acid. Future J Pharm Sci. 2018; 4(2): 248- 53p. https://doi.org/10.1016/j.fjps.2018.08.001
23. Panda VS, Khambat PD. 2014. Antiulcer activity of Garciniaindica fruit rind (kokum berry) in rats. Biomed Aging Pathol. 2014; 4(4): 309-16p. https://doi.org/10.1016/j.biomag.2014.07.008
24. Meter JCV, Oleson JJ. Effect of Tagathen on Histamine-Induced Gastric Lesions in Guinea Pig. Proc Soc Exp Biol Med. 1949; 71(1): 163-5p. https://doi.org/10.3181/00379727-71-17118
25. Balibrea JL, Gomez J, Aznar J, et al.Effects of Somatostatin on Gastric Mucosal Histamine and Serotonin Content in Restrained Rats. Eur Surg Res. 1979; 11(1): 8-14p. https://doi.org/10.1159/000128047
26. Alphin RS, Ward JW. An investigation of antihistaminic activity and gastric ulceration. EurJ Pharmacol. 1969; 6(1): 61-6p. https://doi.org/10.1016/0014-2999(69)90066-1
27. Cho CH, Pfeiffer CJ. Gastrointestinal ulceration in the guinea pig in response to dimaprit, histamine, and H1- and H2- blocking agents. Dig Dis Sci. 1981; 26(4). 306-11p. https://doi.org/10.1007/BF01308370
28. Grover JK, Adiga G, Vats V, et al. Extracts of Benincasahispidaprevent development of experimental ulcers. J Ethnopharmacol. 2001; 78(2-3): 159-64p. https://doi.org/10.1016/S0378-8741(01)00334-8
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Khan MS, Arora P, Kalra N, Arora N. In Vivo and In Vitro Animal Models for Ulcer: A Conscious Review. JDDT [Internet]. 15Nov.2022 [cited 1Dec.2023];12(6):227-31. Available from: https://jddtonline.info/index.php/jddt/article/view/5690
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