A study on Formulation and Evaluation of Gastroretentive tablet incorporating Ciprofloxacin Hydrochloride
Abstract
Ciprofloxacin is a broad spectrum fluoroquinolone antibiotic effective in a broad range of infections including some difficult to treat ones. Because of wide-spectrum bactericidal activity, oral efficacy and good tolerability, it is used in Urinary tract infection, Gonorrhea, Bacterial gastroenteritis, Typhoid, Bone, soft tissue and gynecological infection, Respiratory infection and tuberculosis. The main objective of formulating the floating system was to reduce the frequency of administration, to improve patient compliance and improve bioavailability of drug by preparing a gastroretentive drug delivery system. Floating tablets of Ciprofloxacin hydrochloride were prepared by employing two different grades of control releasing polymers HPMC K4M and HPMC K100M in different concentration. Sodium bicarbonate was incorporated as a gas-generating agent. The tablets were evaluated for uniformity of weight, hardness, friability, drug content, floating behavior, swelling studies and dissolution studies. Among tablet formulations, formulation F3 showed maximum drug release i.e. 92.25% at the end of 12 h compared with other formulations and was concluded as optimized one.
Keywords: Ciprofloxacin HCl, floating tablets, HPMC K4M, HPMC K 100M, FTIR.
Keywords:
Ciprofloxacin HCl, floating tablets, HPMC K4M, HPMC K 100M, FTIRDOI
https://doi.org/10.22270/jddt.v12i4-S.5501References
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