Advances in taste masking of drug: a review study

  • Hemant Kusumakar Fating P. Wadhwani College of Pharmacy Yavatmal Maharashtra 445001
  • Janhavi Vilas Ambadkar P. Wadhwani College of Pharmacy Yavatmal Maharashtra 445001
  • Archana Dinkarrao Kajale Assistant professor, P. Wadhwani college of Pharmacy yavatmal Maharashtra 445001

Abstract

Taste is the ability to determine the flavor of substances like food, drug, etc. The aspect of taste only occurs when the drug get soluble in saliva. Firstly the drug gets dispersible in saliva then they show interaction with taste bud and then perception of taste is occurred. The above test receptor get binds to the molecules of saliva and generates the electrical impulses from the area of brain that area is cranial nerves 7th ,9th 10th and then perception of taste occurs. Currently varieties of drugs are available like cardiac, analgesic, anti-inflammatory, opioid analgesic, anti-epileptic, anticoagulant, oral vaccine and sex hormone. Due to bitter formulation it tends to patient complain the problem of bitter and unpleasant taste of drug in the pediatrics and geriatric formulation is provocation to the pharmacist in the current scenario .Bitter taste masking become important to solve patient complain. This is become most important issue regards with pharmaceutical therapies. Taste masking get broadly classify into physical, chemical, biochemical and organoleptic methods. There are different types of method are available to mask the unpleasant taste of drug. The physical method involves the use of sweeteners and flavor enhancers. The chemical method involves Ion exchange resin, solid dispersions, spray drying, Inclusion complex, Microencapsulation, coating. The biochemical method involves Prodrug, Hot melt extrusion. The most abundantly used method involves are spray drying, Inclusion complex, Microencapsulation, coating, hot-melt extrusion, and organoleptic methods.  


Keywords: Obnoxious, Hot melt Extrusion, Ion exchange resin, coating, palatability.  

Keywords: Obnoxious, Hot melt Extrusion, Ion exchange resin, coating, palatability

Downloads

Download data is not yet available.

Author Biographies

Hemant Kusumakar Fating, P. Wadhwani College of Pharmacy Yavatmal Maharashtra 445001

Student , P. Wadhwani College of Pharmacy Yavatmal Maharashtra 445001

Janhavi Vilas Ambadkar, P. Wadhwani College of Pharmacy Yavatmal Maharashtra 445001

Student, P. Wadhwani College of Pharmacy Yavatmal Maharashtra 445001

Archana Dinkarrao Kajale, Assistant professor, P. Wadhwani college of Pharmacy yavatmal Maharashtra 445001

Assistant professor, P. Wadhwani college of Pharmacy yavatmal Maharashtra 445001

References

1. Wadhwa J, Puri S. Taste Masking: A Novel Approch For Bitter And Obnoxious Drugs. 1(1):15.
2. Sohi H, Sultana Y, Khar RK. Taste Masking Technologies in Oral Pharmaceuticals: Recent Developments and Approaches. Drug Dev Ind Pharm. 2004 Jan; 30(5):429-48. https://doi.org/10.1081/DDC-120037477
3. Wagh VD, Ghadlinge SV. Taste Masking Methods and Techniques in Oral Pharmaceuticals: Current Perspectives. J Pharm Res. 2009;(6):6.
4. Kumar RS, Kiran AS. Taste masking Technologies: A Boon for Oral Administration of Drugs. J Drug Deliv. :5.
5. Kumar KPS, Bhowmik D, Deb L, Yadav A, Dutta AS. Recent Trends In Taste Masking Of Bitter Drugs. 2012; 1(1):10.
6. Ayenew Z, Puri V, Kumar L, Bansal A. Trends in Pharmaceutical Taste Masking Technologies: A Patent Review. Recent Pat Drug Deliv Formul. 2009 Jan 1; 3(1):26-39. https://doi.org/10.2174/187221109787158364
7. Zheng X, Wu F, Hong Y, Shen L, Lin X, Feng Y. Developments in Taste-Masking Techniques for Traditional Chinese Medicines. Pharmaceutics. 2018 Sep 12; 10(3):157. https://doi.org/10.3390/pharmaceutics10030157
8. Vummaneni V, Nagpal D. Taste Masking Technologies: An Overview and Recent Updates. 3:15.
9. Mennella JA, Spector AC, Reed DR, Coldwell SE. The Bad Taste of Medicines: Overview of Basic Research on Bitter Taste. Clin Ther. 2013 Aug; 35(8):1225-46. https://doi.org/10.1016/j.clinthera.2013.06.007
10. Bora D, Borude P, Bhise K. Taste Masking by Spray-Drying Technique. AAPS PharmSciTech. 2008 Dec; 9(4):1159-64. https://doi.org/10.1208/s12249-008-9154-5
11. Sajal JK, Uday SR, Surendra V. TASTE MASKING IN PHARMACEUTICALS: AN UPDATE. J Pharm Res. 2008; 2:5.
12. Sonawane VM, Saiffee M, Shinde NY, Hawaldar AH, Pawar A. An update of taste masking methods and evaluation techniques. 2010; 15.
13. Birhade ST, Bankar VH, Gaikwad PD, Pawar SP. Preparation and Evaluation of Cyclodextrin Based Binary Systems for Taste Masking. 2010; 2(3):5.
14. Sagar T, Amol G, Rahul D, Prashant P, Yogesh S. Review On: Taste masking approaches and Evaluation of Taste Masking. :14.
15. Zheng X, Wu F, Hong Y, Shen L, Lin X, Feng Y. Developments in Taste-Masking Techniques for Traditional Chinese Medicines. Pharmaceutics. 2018 Sep 12; 10(3):157. https://doi.org/10.3390/pharmaceutics10030157
16. Wagh VD. Taste Masking Methods and Techniques in Oral Pharmaceuticals: Current Perspectives. J Pharm Res. 2009; 6:6.
17. Gupta P, Tiwari A, Mishra MK, Taste masking of drugs: an extended approach. Int J Curr Adv Res. 2017 Mar 28; 6(3):2571-8. https://doi.org/10.24327/ijcar.2017.2578.0051
18. Haraguchi T, Yoshida M, Kojima H, Uchida T. Usefulness and limitations of taste sensors in the evaluation of palatability and taste-masking in oral dosage forms. Asian J Pharm Sci. 2016 Aug; 11(4):479-85. https://doi.org/10.1016/j.ajps.2016.03.001
Statistics
33 Views | 4 Downloads
How to Cite
1.
Fating H, Ambadkar J, Kajale A. Advances in taste masking of drug: a review study. JDDT [Internet]. 18Jun.2022 [cited 1Jul.2022];12(3-S):262-7. Available from: https://jddtonline.info/index.php/jddt/article/view/5442