FORMULATION AND EVALUATION OF ZIDOVUDINE NANOSUSPENSIONS USING A NOVEL BIO POLYMER FROM THE SEEDS OF BUCHANANIA LANZAN

Abstract

The aim of the research work was to isolate a novel bio material from the seeds of Buchanania Lanzan and to evaluate their potential for sustained drug delivery by formulating various nano suspension using methylene chloride as organic solvent and biomaterial. The biopolymer was isolated from the seeds of Buchanania Lanzan by simplified economical method.Five formulation were prepared using biomaterial in different ratios by solvent evaporation according to OECD guidelines. The formulated nano suspension were subjected for various evaluation parameters like particle size and shape, drug content, entrapment efficacy and % transmittance and invitro drug release studies. On the basis of invitro release studies, the formulation with increased amount of bio polymer (FNS4)  was found to be better than the other formulations and it was selected as an optimized formulation . Invitro studies revealed that FNS4 followed perfect zero first order kinetics release. It was observed that the increasing the proportion of bio polymer increases the rate of release of zidovudine.