Estimation of Fibrinogen Level among Ischemic Stroke Patients in Khartoum State-2021
Abstract
Background: Ischemic stroke is known as rapidly progressing clinical feature of focal disturbance of cerebral function extending for more than 24 hours or leading to death, with no apparent cause other than vascular origin
Material and methods: This was a case control study conducted at the research laboratory of the national center of neurological sciences, Khartoum, Sudan during the period July to November, 2021, and aimed to estimate of fibrinogen level among Sudanese patients with ischemic stroke. 50 patients attending police hospital and diagnosed with IS were selected as case group. In addition to that, apparently healthy individuals with no history of stroke were selected as control group. 1.8 ml of blood samples were collected in sodium citrate anticoagulant container for measurement of fibrinogen level by clauss method in coagulometer device.
Results: For the fibrinogen level the result observed significance increase in the mean of fibrinogen level in case group when compared to control group with (P ≤ 0.05). However there was insignificance correlation between fibrinogen level and age, gender, family history, hypertension and smoking the P value was (0.350, 0.900, 0.875, 0.378, 0.435, 0.417) respectively.
Conclusion: The study concluded that there was clearly increase in the fibrinogen level in case group when compared to control group. And there was insignificant correlation of fibrinogen level with risk factors (age, gender, smoking, family history, hypertension and diabetes Miletus)
Keywords: Ischemic stroke, fibrinogen level smoking, hypertension and diabetes Miletus
Keywords:
Ischemic stroke, fibrinogen level smoking, hypertension, diabetes MiletusDOI
https://doi.org/10.22270/jddt.v11i6-S.5258References
Lakhan SE, Kirchgessner A and Hofer M. Inflammatory mechanisms in ischemic stroke: therapeutic approaches. J Transll Med 2009; 7: 97-107. https://doi.org/10.1186/1479-5876-7-97
Allen CL, Bayraktutan U. Risk factors for ischaemic stroke. Int J Stroke. 2008; 3(2):105-16. PMID: 18706004. https://doi.org/10.1111/j.1747-4949.2008.00187.x
Hossman KA and Heiss WD. Etiology, Pathophysiology and Imaging. Neuropathology and Pathophysiology of stroke. Textbook of Stroke Medicine, 1st Edition 2010, Section-1, Chapter-1, 01-10.
Mass MB and Safdieh JE. Ischemic Stroke: Pathophysiology and Principles of Localization. Neurology 2009; 13(1):02-16.
Dziedzic T. Clinical significance of acute phase reaction in stroke patients. Front Bio sci 2008; 13:2922-2927. https://doi.org/10.2741/2897
HarrisonPM.TheStructureand Functionof Ferritin.BiochemEdu1986; 14(4):154-162. https://doi.org/10.1016/0307-4412(86)90203-7
AbdelgawadDM, Elbassiouny AA,Youssef RA, Eldin NS and Elrakawy MH. ElevatedPlasma Fibrinogen Levels Predict Poor Clinical Outcome after Acute Ischemic Stroke. Egypt JNeurolPsych Neurosurg2014; 51(1):61-67.
MinnoGD, CerboneA, MargaglioneM,VecchioneG,GrandoneEandManciniM. Fibrnogen and Mechanisms of Thrombosis. ADifficult Link. EuroJEpidemiol 1992; 8:88-91. https://doi.org/10.1007/BF00145357
Barazzoni R, Zanetti MG. Kiwanuka DE, Carraro P, Tiengo A, TessariP.Increasedfibrinogen production in type 2 diabetic patients without detectable vascular complications: correlation with plasma glucagon concentrations. The Journal of Clinical Endocrinology and Metabolism 2000; 85:3121-3125. https://doi.org/10.1210/jcem.85.9.6779
Ernst E. Regional variations in plasma fibrinogen levels. Ann of internal medicine 1991; 115(4):329-330. https://doi.org/10.7326/0003-4819-115-4-329_2
- Perumalla V K and Gaddam S R. Estimation of Plasma Fibrinogen Levels in Acute Stroke Patients, JMSCR 2018; 06(10):20-23.
- Pikija S, Trkulja V, Mutzenbach JS, et al. Fibrinogen consumption is related to intracranial clot burden in acute ischemic stroke: a retrospective hyperdense artery study. J. Transl. Med 2016; 14(1):250 https://doi.org/10.1186/s12967-016-1006-6
- Marta Swarowska, Aleksandra JanowskaAgnieszkaPolczak, Aleksandra KlimkowiczMrowiec, Joanna Pera, Agnieszka Slowik and Tomasz Dziedzic. The Sustained Increase of Plasma Fibrinogen During Ischemic Stroke Predicts Worse Outcome Independently of Baseline Fibrinogen Level. Inflammation. 2014; 37(4):1142-1147 https://doi.org/10.1007/s10753-014-9838-9
- Marieta P, Tanya D, ZahariZ,The role of fibrinogen in acute ischaemic stroke Polish Journal of Neurology and Neurosurgery 2021; 55(1):74-80. DOI: 10.5603/PJNNS.a2020.0094 https://doi.org/10.5603/PJNNS.a2020.0094
Published
Abstract Display: 507 
PDF Downloads: 440 PDF Downloads: 32 How to Cite
Issue
Section
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0). that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
How to Cite
.