Design, Development and Characterization of Nanoemulsion developed by High Pressure Homogenization (HPH) method Containing Antifungal Drug

  • Ashish Gorle R. C. Patel Institute of Pharmaceutical Education & Research, Shirpur-425405, Dhule, Maharashtra, India
  • Kalpesh Ahire R. C. Patel Institute of Pharmaceutical Education & Research, Shirpur-425405, Dhule, Maharashtra, India
  • Rutuja Shende R. C. Patel Institute of Pharmaceutical Education & Research, Shirpur-425405, Dhule, Maharashtra, India

Abstract

Nanoemulsion is one the most attractive drug delivery for researchers to treat fungal diseases and getting interested in increasing the solubility of low soluble drugs. The objective of this research was to develop a topical nanoemulsion formulation of Posaconazole drug with the intention to enhance its aqueous solubility and local action. By employing High Pressure Homogenization (HPH) method, oil in water nanoemulsion was formulated with 0.2% cinnamon oil as lipid phase, 0.4% tween-80 and poloxamer-188 as surfactants, 0.2% transcutol as a co-surfactant. The physical characteristics of formulations were found to be stable after thermodynamic stability testing. In-vitro diffusion study for optimized nanoemulsion was performed using a dialysis bag membrane and cumulative % drug release was determined. Viscosity and percent drug content was observed to be 0.0593 cps and 90.21 ± 0.23% respectively. The optimized nanoemulsion formulation (F8) was evaluated to be transparent and thermodynamically stable, with -9.46 zeta potential, 78.79 nm particle size, 0.315 polydispersity index. The optimized Nanoemulsion was stable for 3 month in three different temperature conditions. The result from the release study was indicative of improved solubility of Posaconazole, which may serve to boost up the action of the drug for the treatment of fungal diseases.


Keywords: Posaconazole, Nanoemulsion, HPH method, Physical Characterization

Keywords: Posaconazole, Nanoemulsion, HPH method, Physical Characterization

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Author Biographies

Ashish Gorle, R. C. Patel Institute of Pharmaceutical Education & Research, Shirpur-425405, Dhule, Maharashtra, India

R. C. Patel Institute of Pharmaceutical Education & Research, Shirpur-425405, Dhule, Maharashtra, India

Kalpesh Ahire, R. C. Patel Institute of Pharmaceutical Education & Research, Shirpur-425405, Dhule, Maharashtra, India

R. C. Patel Institute of Pharmaceutical Education & Research, Shirpur-425405, Dhule, Maharashtra, India

Rutuja Shende, R. C. Patel Institute of Pharmaceutical Education & Research, Shirpur-425405, Dhule, Maharashtra, India

R. C. Patel Institute of Pharmaceutical Education & Research, Shirpur-425405, Dhule, Maharashtra, India

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Gorle A, Ahire K, Shende R. Design, Development and Characterization of Nanoemulsion developed by High Pressure Homogenization (HPH) method Containing Antifungal Drug. JDDT [Internet]. 15Mar.2022 [cited 25Sep.2022];12(2):24-2. Available from: https://jddtonline.info/index.php/jddt/article/view/5245