EFFECT OF INTERACTION BETWEEN METFORMIN AND GLIMIPERIDE ON GLYCOSYLATED HAEMOGLOBIN AND LIPID PROFILE IN STRESS INDUCED TYPE 2 DM
Abstract
The aim of the present study is to evalutae the effect of metformin in combination with Glimepiride and in patient with type 2 Diabetes Mellitus.The research is carried out to  study the effect of metformin when it is given in combination on glycaemic control in patient with type 2 Diabetes Mellitus. Patients with Glycosylated Hemoglobin more than 6.5% were included in the study. 30 animal in five group were randomly assigned for treatment based on metformin and glimepiride in a dose of 200 mg/kg and 17.5 mg/kg for 21 weeks. The comparisons were conducted between these five groups for HbA1C, FPG, PPG and lipid profile. On week 21, the significant reductions in HbA1c were found in drug treated groups but the patients treated with metformin and glimepiride resulted in significantly greater reductions in HbA1C  . Also the greater significant reductions were observed in case of FPG, total cholesterol, serum triglyceride and LDL cholesterol in patient with metformin and glimepiride treated group.
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Key word-Metformin,glimiperide,Diabetes,hypoglycemic agent,safetyDOI
https://doi.org/10.22270/jddt.v3i3.522
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