Assistance of Gut Microbiota in Depression

Authors

  • Reeja T Reji Post Graduate Student, Department of Pharmacy Practice, J.K.K. Nattraja College of Pharmacy, Namakkal (Dt), Kumarapalayam- 638 183, Tamil Nadu, India.
  • Krishna Ravi Assistant Professor, Department of Pharmacy Practice, J.K.K. Nattraja College of Pharmacy, Namakkal (Dt), Kumarapalayam- 638 183, Tamil Nadu, India.
  • R. Sambath Kumar Professor and Head, Department of Pharmaceutics, J.K.K. Nattraja College of Pharmacy, Namakkal (Dt), Kumarapalayam- 638 183, Tamil Nadu, India. https://orcid.org/0000-0003-1454-9582

Abstract

The association between gut microbiota and mental health is a relatively new research topic that has gained traction in recent years. Depression is a serious mental illness and a leading cause of disability, morbidity, and mortality worldwide. Based on the WHO reports, there are approximately 350 million people affected by depression globally. Currently available treatments can temporarily alleviate the symptoms of depressive illness, but these management plans are unable to completely reverse the multifactorial pathology of depression, and the antidepressant medications may produce side effects and adverse drug reactions which may turn down the quality of life of patients. Research has shown that the gut microflora interacts with the brain through various mechanisms, and this leads to the recognition of the microbiome in managing mental health. By unveiling the complexities involved in this area can help to develop novel strategies to treat the depressed patients and to prevent the public from falling to depressive disorder.

Keywords: Gut microbiome, depression, neurotransmitters

Keywords:

Gut microbiome, depression, neurotransmitters

DOI

https://doi.org/10.22270/jddt.v11i6-S.5202

Author Biographies

Reeja T Reji, Post Graduate Student, Department of Pharmacy Practice, J.K.K. Nattraja College of Pharmacy, Namakkal (Dt), Kumarapalayam- 638 183, Tamil Nadu, India.

Post Graduate Student, Department of Pharmacy Practice, J.K.K. Nattraja College of Pharmacy, Namakkal (Dt), Kumarapalayam- 638 183, Tamil Nadu, India.

Krishna Ravi, Assistant Professor, Department of Pharmacy Practice, J.K.K. Nattraja College of Pharmacy, Namakkal (Dt), Kumarapalayam- 638 183, Tamil Nadu, India.

Assistant Professor, Department of Pharmacy Practice, J.K.K. Nattraja College of Pharmacy, Namakkal (Dt), Kumarapalayam- 638 183, Tamil Nadu, India.

R. Sambath Kumar, Professor and Head, Department of Pharmaceutics, J.K.K. Nattraja College of Pharmacy, Namakkal (Dt), Kumarapalayam- 638 183, Tamil Nadu, India.

Professor and Head, Department of Pharmaceutics, J.K.K. Nattraja College of Pharmacy, Namakkal (Dt), Kumarapalayam- 638 183, Tamil Nadu, India.

References

Rea K, Dinan TG, Cryan JF. Gut Microbiota: A Perspective for Psychia-trists. Neuropsychobiology. 2020; 79(1):50-62. doi:10.1159/000504495

Pickard JM, Núñez G. Pathogen Colonization Resistance in the Gut, and Its Manipulation for Improved Health. Am J Pathol. 2019; 189(7):1300-1310. doi:10.1016/j.ajpath.2019.03.003

Bull MJ, Plummer NT. Part 1: The Human Gut Microbiome in Health and Disease. Integr Med (Encinitas). 2014; 13(6):17-22.

Bates M. Gut Feeling: Researchers Are Discovering a Link Between Depression and Gut Bacteria. IEEE Pulse. 2017; 8(6):15-18. doi:10.1109/MPUL.2017.2751118

Clapp M, Aurora N, Herrera L, Bhatia M, Wilen E, Wakefield S. Gut microbiota's effect on mental health: The gut-brain axis. Clin Pract. 2017; 7(4):987. Published 2017 Sep 15. doi:10.4081/cp.2017.987

GBD 2017 Disease and Injury Incidence and Prevalence Collaborators. Global, regional, and national incidence, prevalence, and years lived with disability for 354 diseases and injuries for 195 countries and territories, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017 [published correction appears in Lancet. 2019 Jun 22; 393(10190):e44]. Lancet.2018; 392(10159):1789-1858. doi:10.1016/S0140-6736(18)32279-7

Pratt LA, Brody DJ. Depression in the U.S. household population, 2009-2012. NCHS Data Brief. 2014; 172:1-8.

Carabotti M, Scirocco A, Maselli MA, Severi C. The gut-brain axis: inter-actions between enteric microbiota, central and enteric nervous sys-tems. Ann Gastroenterol. 2015; 28(2):203-209.

Segata, N., Haake, S.K., Mannon, P. et al. Composition of the adult diges-tive tract bacterial microbiome based on seven mouth surfaces, tonsils, throat and stool samples. Genome Biol 2012; 13:R42. Doi:https://doi.org/10.1186/gb-2012-13-6-r42

Zoetendal, E., Raes, J., van den Bogert, B. et al. The human small intesti-nal microbiota is driven by rapid uptake and conversion of simple car-bohydrates. ISME J 2012; 6:1415–1426. https://doi.org/10.1038/ismej.2011.212

Nutt DJ. Relationship of neurotransmitters to the symptoms of major depressive disorder. J Clin Psychiatry. 2008; 69 Suppl E1:4-7.

Luscher B, Shen Q, Sahir N. The GABAergic deficit hypothesis of major depressive disorder. Mol Psychiatry. 2011; 16(4):383-406. doi:10.1038/mp.2010.120

Cai Y, Xing L, Yang T, et al. The neurodevelopmental role of dopaminergic signaling in neurological disorders. Neurosci Lett. 2021; 741:135540. doi:10.1016/j.neulet.2020.135540

Nieoullon A. Dopamine and the regulation of cognition and atten-tion. Prog Neurobiol. 2002; 67(1):53-83. doi:10.1016/s0301-0082(02)00011-4

Baik J-H, Dopamine signaling in reward-related behaviors. Front. Neural Circuits 2013; 7:152. doi: 10.3389/fncir.2013.00152

González-Arancibia C, Urrutia-Piñones J, Illanes-González J, et al. Do your gut microbes affect your brain dopamine?. Psychopharmacology (Berl). 2019; 236(5):1611-1622. doi:10.1007/s00213-019-05265-5

Blaess S, Stott SRW, Ang S-L. The generation of midbrain dopaminergic neurons. In: Rubenstein J, Rakic P, editors. Patterning and Cell Type Specification in the Developing CNS and PNS: Comprehensive Devel-opmental Neuroscience. 2nd ed. London: Academic Press; 2020. p.369-388. DOI:10.1016/B978-0-12-814405-3.00017-5.

Eisenhofer G, Aneman A, Friberg P, et al. Substantial production of dopamine in the human gastrointestinal tract. J Clin Endocrinol Metab. 1997; 82(11):3864-3871. doi:10.1210/jcem.82.11.4339

Luqman A, Nega M, Nguyen MT, Ebner P, Götz F. SadA-Expressing Staphylococci in the Human Gut Show Increased Cell Adherence and Internalization. Cell Rep. 2018; 22(2):535-545. doi:10.1016/j.celrep.2017.12.058

Matsumoto M, Kibe R, Ooga T, Aiba Y, Sawaki E, Koga Y and Benno Y, Cerebral low-molecular metabolites influenced by intestinal microbiota: a pilot study. Front. Syst. Neurosci. 2013; 7:9. doi: 10.3389/fnsys.2013.00009

Squire LR. Encyclopedia of Neuroscience. 1 st ed. Amsterdam:Academic press; 2009 . P. 1221-1230.

What is Norepinephrine.by cathy cassata medically reviewed by Jamer MD reviewed dec 11,2015 everyday health newsletter. Re-viewed: December 11, 2015

Lambert G, Johansson M, Agren H, Friberg P. Reduced brain norepi-nephrine and dopamine release in treatment-refractory depressive ill-ness: evidence in support of the catecholamine hypothesis of mood disorders. Arch Gen Psychiatry. 2000; 57(8):787-793. doi:10.1001/archpsyc.57.8.787

Strandwitz P. Neurotransmitter modulation by the gut microbio-ta. Brain Res. 2018; 1693(Pt B):128-133. doi:10.1016/j.brainres.2018.03.015.

Asano Y, Hiramoto T, Nishino R, et al. Critical role of gut microbiota in the production of biologically active, free catecholamines in the gut lu-men of mice. Am J Physiol Gastrointest Liver Physiol. 2012; 303(11):G1288-G1295. doi:10.1152/ajpgi.00341.2012

Claustre Y, Leonetti M, Santucci V, et al. Effects of the beta3-adrenoceptor (Adrb3) agonist SR58611A (amibegron) on serotonergic and noradrenergic transmission in the rodent: relevance to its antide-pressant/anxiolytic-likeprofile. Neuroscience.2008; 156(2):353-364. doi:10.1016/j.neuroscience.2008.07.011

Kambe J, Watcharin S, Makioka-Itaya Y, et al. Heat-killed Enterococcus fecalis (EC-12) supplement alters the expression of neurotransmitter receptor genes in the prefrontal cortex and alleviates anxiety-like be-havior in mice. Neurosci Lett. 2020; 720:134753. doi:10.1016/j.neulet.2020.134753

Song S, Liu J, Zhang F, Hong JS. Norepinephrine depleting toxin DSP-4 and LPS alter gut microbiota and induce neurotoxicity in α-synuclein mutant mice. Sci Rep. 2020; 10(1):15054. Published 2020 Sep 14. doi:10.1038/s41598-020-72202-4

Wu M, Tian T, Mao Q , et al. Associations between disordered gut mi-crobiota and changes of neurotransmitters and short-chain fatty acids in depressed mice. Transl Psychiatry . 2020; 10(1):350. DOI:10.1038/s41398-020-01038-3

Desbonnet L, Garrett L, Clarke G, Kiely B, Cryan JF, Dinan TG. Effects of the probiotic Bifidobacterium infantis in the maternal separation model of depression. Neuroscience. 2010; 170(4):1179-1188. doi:10.1016/j.neuroscience.2010.08.005

O'Mahony SM, Clarke G, Borre YE, Dinan TG, Cryan JF. Serotonin, tryp-tophan metabolism and the brain-gut-microbiome axis. Behav Brain Res. 2015; 277:32-48. doi:10.1016/j.bbr.2014.07.027

Yano JM, Yu K, Donaldson GP, et al. Indigenous bacteria from the gut microbiota regulate host serotonin biosynthesis [published correction appears in Cell. 2015 Sep 24; 163:258]. Cell. 2015;161(2):264-276. doi:10.1016/j.cell.2015.02.047

Williams BB, Van Benschoten AH, Cimermancic P, et al. Discovery and characterization of gut microbiota decarboxylases that can produce the neurotransmitter tryptamine. Cell Host Microbe. 2014; 16(4):495-503. doi:10.1016/j.chom.2014.09.001

aan het Rot M, Mathew SJ, Charney DS. Neurobiological mechanisms in major depressive disorder. CMAJ. 2009; 180(3):305-313. doi:10.1503/cmaj.080697

Liang S, Wang T, Hu X, et al. Administration of Lactobacillus helveticus NS8 improves behavioral, cognitive, and biochemical aberrations caused by chronic restraint stress. Neuroscience. 2015; 310:561-577. doi:10.1016/j.neuroscience.2015.09.033

Xie R, Jiang P, Lin L, et al. Oral treatment with Lactobacillus reuteri attenuates depressive-like behaviors and serotonin metabolism altera-tions induced by chronic social defeat stress. J Psychiatr Res. 2020; 122:70-78. doi:10.1016/j.jpsychires.2019.12.013

Cryan JF, Kaupmann K. Don't worry 'B' happy!: a role for GABA(B) receptors in anxiety and depression. Trends Pharmacol Sci. 2005; 26(1):36-43. doi:10.1016/j.tips.2004.11.004

Sanacora G, Saricicek A. GABAergic contributions to the pathophysiology of depression and the mechanism of antidepressant action. CNS Neurol Disord Drug Targets. 2007; 6(2):127-140. doi:10.2174/187152707780363294

Bhagwagar Z, Wylezinska M, Jezzard P, et al. Reduction in occipital cortex gamma-aminobutyric acid concentrations in medication-free recovered unipolar depressed and bipolar subjects. Biol Psychiatry. 2007; 61(6):806-812. doi:10.1016/j.biopsych.2006.08.048

Hasler G, van der Veen JW, Tumonis T, Meyers N, Shen J, Drevets WC. Reduced prefrontal glutamate/glutamine and gamma-aminobutyric acid levels in major depression determined using proton magnetic resonance spectroscopy. Arch Gen Psychiatry. 2007; 2007;64(2):193-200 doi:10.1001/archpsyc.64.2.193

Price RB, Shungu DC, Mao X, et al. Amino acid neurotransmitters as-sessed by proton magnetic resonance spectroscopy: relationship to treatment resistance in major depressive disorder. Biol Psychiatry. 2009; 65(9):792-800. doi:10.1016/j.biopsych.2008.10.025

Sanacora G, Mason GF, Rothman DL, et al. Reduced cortical gamma-aminobutyric acid levels in depressed patients determined by proton magnetic resonance spectroscopy. Arch Gen Psychiatry. 1999; 56(11):1043-1047. doi:10.1001/archpsyc.56.11.1043

Sanacora G, Gueorguieva R, Epperson CN, et al. Subtype-specific altera-tions of gamma-aminobutyric acid and glutamate in patients with ma-jor depression. Arch Gen Psychiatry. 2004; 61(7):705-713. doi:10.1001/archpsyc.61.7.705

Strandwitz P, Kim KH, Terekhova D, et al. GABA-modulating bacteria of the human gut microbiota. Nat Microbiol. 2019; 4(3):396-403. doi:10.1038/s41564-018-0307-3

Otaru N, Ye K, Mujezinovic D, et al. GABA Production by Human Intestinal Bacteroides spp.: Prevalence, Regulation, and Role in Acid Stress Tolerance. Front Microbiol. 2021; 12:656895. Published 2021 Apr 15. doi:10.3389/fmicb.2021.656895

Zheng P, Zeng B, Zhou C, et al. Gut microbiome remodeling induces depressive-like behaviors through a pathway mediated by the host's metabolism. Mol Psychiatry. 2016; 21(6):786-796. doi:10.1038/mp.2016.44

Valles-Colomer M, Falony G, Darzi Y, et al. The neuroactive potential of the human gut microbiota in quality of life and depression. Nat Micro-biol. 2019; 4(4):623-632. doi:10.1038/s41564-018-0337-x

Jiang H, Ling Z, Zhang Y, et al. Altered fecal microbiota composition in patients with major depressive disorder. Brain Behav Immun. 2015; 48:186-194. doi:10.1016/j.bbi.2015.03.016

Naseribafrouei A, Hestad K, Avershina E, et al. Correlation between the human fecal microbiota and depression. Neurogastroenterol Motil. 2014; 26(8):1155-1162. doi:10.1111/nmo.12378

Yu M, Jia H, Zhou C, et al. Variations in gut microbiota and fecal meta-bolic phenotype associated with depression by 16S rRNA gene se-quencing and LC/MS-based metabolomics. J Pharm Biomed Anal. 2017; 138:231-239. doi:10.1016/j.jpba.2017.02.008

Peter J, Fournier C, Durdevic M, et al. A Microbial Signature of Psycho-logical Distress in Irritable Bowel Syndrome. Psychosom Med. 2018; 80(8):698-709. doi:10.1097/PSY.0000000000000630

Heiman ML, Greenway FL. A healthy gastrointestinal microbiome is dependent on dietary diversity. Mol Metab. 2016; 5(5):317-320. Pub-lished 2016 Mar 5. doi:10.1016/j.molmet.2016.02.005

Yatsunenko T, Rey FE, Manary MJ, et al. Human gut microbiome viewed across age and geography. Nature. 2012; 486(7402):222-227. Published 2012 May 9. doi:10.1038/nature11053

De Filippo C, Cavalieri D, Di Paola M, et al. Impact of diet in shaping gut microbiota revealed by a comparative study in children from Europe and rural Africa. Proc Natl Acad Sci USA. 2010; 107(33):14691-14696. doi:10.1073/pnas.1005963107

Clemente JC, Pehrsson EC, Blaser MJ, et al. The microbiome of uncon-tacted Amerindians. Sci Adv. 2015; 1(3):e1500183. doi:10.1126/sciadv.1500183

Obregon-Tito AJ, Tito RY, Metcalf J, et al. Subsistence strategies in traditional societies distinguish gut microbiomes. Nat Commun. 2015; 6:6505. Published 2015 Mar 25. doi:10.1038/ncomms7505

Martínez I, Stegen JC, Maldonado-Gómez MX, et al. The gut microbiota of rural papua new guineans: composition, diversity patterns, and eco-logical processes. Cell Rep. 2015; 11(4):527-538. doi:10.1016/j.celrep.2015.03.049

De Filippo C, Di Paola M, Ramazzotti M, et al. Diet, Environments, and Gut Microbiota. A Preliminary Investigation in Children Living in Rural and Urban Burkina Faso and Italy. Front Microbiol. 2017; 8:1979. Pub-lished 2017 Oct 13. doi:10.3389/fmicb.2017.01979

Robertson R. 9 Ways to Improve Your Gut Bacteria, Based on Science; 2021.Available at:https://www.healthline.com/nutrition/improve-gut-bacteria. Accessed Nov 10,2021

Głąbska D, Guzek D, Groele B, Gutkowska K. Fruit and Vegetable Intake and Mental Health in Adults: A Systematic Review. Nutrients. 2020; 12(1):115. Published 2020 Jan 1. doi:10.3390/nu12010115

Selhub EM, Logan AC, Bested AC. Fermented foods, microbiota, and mental health: ancient practice meets nutritional psychiatry. J Physiol Anthropol. 2014; 33(1):2. Published 2014 Jan 15. doi:10.1186/1880-6805-33-2

Bayes J, Schloss J, Sibbritt D. Effects of Polyphenols in a Mediterranean Diet on Symptoms of Depression:A Systematic LiteratureRe-view. AdvNutr.2020;11(3):602-615. doi:10.1093/advances/nmz117

Yong SJ, Tong T, Chew J, Lim WL. Antidepressive Mechanisms of Probiotics and Their Therapeutic Potential. Front Neurosci. 2020; 13:1361. Published 2020 Jan 14. doi:10.3389/fnins.2019.01361

Johnson D, Thurairajasingam S, Letchumanan V, Chan KG, Lee LH. Exploring the Role and Potential of Probiotics in the Field of Mental Health: Major Depressive Disorder. Nutrients. 2021; 13(5):1728. Pub-lished 2021 May 20. doi:10.3390/nu13051728

Didari T, Solki S, Mozaffari S, Nikfar S, Abdollahi M. A systematic review of the safety of probiotics. Expert Opin Drug Saf. 2014; 13(2):227-239. doi:10.1517/14740338.2014.872627

Bindels LB, Delzenne NM, Cani PD, Walter J. Towards a more compre-hensive concept for prebiotics. Nat Rev Gastroenterol Hepatol. 2015; 12(5):303-310. doi:10.1038/nrgastro.2015.47

Kazemi A, Noorbala AA, Azam K, Djafarian K. Effect of prebiotic and probiotic supplementation on circulating pro-inflammatory cytokines and urinary cortisol levels in patients with major depressive disorder: A double-blind, placebo-controlled randomized clinical tri-al.J. Funct. Foods, 2019; 52: 596-602. DOI:10.1016/j.jff.2018.11.041

Carlson JL, Erickson JM, Lloyd BB, Slavin JL. Health Effects and Sources of Prebiotic Dietary Fiber. Curr Dev Nutr. 2018; 2(3):nzy005. Published 2018 Jan 29. doi:10.1093/cdn/nzy005

Noonan S, Zaveri M, Macaninch E, Martyn K. Food & mood: a review of supplementary prebiotic and probiotic interventions in the treatment of anxiety and depression in adults. BMJ Nutr Prev Health. 2020; 3(2):351-362. Published 2020 Jul 6. doi:10.1136/bmjnph-2019-000053

Liu RT, Walsh RFL, Sheehan AE. Prebiotics and probiotics for depres-sion and anxiety: A systematic review and meta-analysis of controlled clinical trials. Neurosci Biobehav Rev. 2019; 102:13-23. doi:10.1016/j.neubiorev.2019.03.023

Li Y, Hao Y, Fan F, Zhang B. The Role of Microbiome in Insomnia, Circa-dian Disturbance and Depression. Front Psychiatry. 2018; 9:669. Pub-lished 2018 Dec 5. doi:10.3389/fpsyt.2018.00669

Benedict C, Vogel H, Jonas W, et al. Gut microbiota and glucometabolic alterations in response to recurrent partial sleep deprivation in nor-mal-weight young individuals. Mol Metab. 2016; 5(12):1175-1186. Published 2016 Oct 24. doi:10.1016/j.molmet.2016.10.003

Clarke SF, Murphy EF, O'Sullivan O, et al. Exercise and associated dietary extremes impact on gut microbial diversity. Gut. 2014; 63(12):1913-1920. doi:10.1136/gutjnl-2013-306541

Queipo-Ortuño MI, Seoane LM, Murri M, et al. Gut microbiota composi-tion in male rat models under different nutritional status and physical activity and its association with serum leptin and ghrelin levels. PLoS One. 2013; 8(5):e65465. Published 2013 May 28. doi:10.1371/journal.pone.0065465

Estaki M, Pither J, Baumeister P, et al. Cardiorespiratory fitness as a predictor of intestinal microbial diversity and distinct metagenomic functions. Microbiome. 2016; 4(1):42. Published 2016 Aug 8. doi:10.1186/s40168-016-0189-7

Wang P, Tu K, Cao P, et al. Antibiotics-induced intestinal dysbacteriosis caused behavioral alternations and neuronal activation in different brain regions in mice [published correction appears in Mol Brain. 2021 Apr 13;14(1):69]. Mol Brain. 2021; 14(1):49. Published 2021 Mar 6. doi:10.1186/s13041-021-00759-w

Jang HM, Lee HJ, Jang SE, Han MJ, Kim DH. Evidence for interplay among antibacterial-induced gut microbiota disturbance, neuro-inflammation, and anxiety in mice. Mucosal Immunol. 2018; 11(5):1386-1397. doi:10.1038/s41385-018-0042-3

Kaur K, Fayad R, Saxena A, et al. Fluoroquinolone-related neuropsychi-atric and mitochondrial toxicity: a collaborative investigation by scientists and members of a social network. J Community Support Oncol. 2016; 14(2):54-65. doi:10.12788/jcso.0167

Hoban AE, Moloney RD, Golubeva AV, et al. Behavioural and neuro-chemical consequences of chronic gut microbiota depletion during adulthood in the rat [published correction appears in Neuroscience. 2017 Mar 6;344:418]. Neuroscience. 2016; 339:463-477. doi:10.1016/j.neuroscience.2016.10.003

Lurie I, Yang YX, Haynes K, Mamtani R, Boursi B. Antibiotic exposure and the risk for depression, anxiety, or psychosis: a nested case-control study. J Clin Psychiatry. 2015;76(11):1522-1528. doi:10.4088/JCP.15m09961

Galley JD, Nelson MC, Yu Z, et al. Exposure to a social stressor disrupts the community structure of the colonic mucosa-associated microbio-ta. BMC Microbiol. 2014; 14:189. Published 2014 Jul 15. doi:10.1186/1471-2180-14-189

Galley JD, Yu Z, Kumar P, Dowd SE, Lyte M, Bailey MT. The structures of the colonic mucosa-associated and luminal microbial communities are distinct and differentially affected by a prolonged murine stressor. Gut Microbes. 2014; 5(6):748-760. doi:10.4161/19490976.2014.972241

Partrick KA, Chassaing B, Beach LQ, McCann KE, Gewirtz AT, Huhman KL. Acute and repeated exposure to social stress reduces gut microbio-ta diversity in Syrian hamsters [published correction appears in Behav Brain Res. 2018 Apr 16;]. Behav Brain Res. 2018; 345:39-48. doi:10.1016/j.bbr.2018.02.005

Braniste V, Al-Asmakh M, Kowal C, et al. The gut microbiota influences blood-brain barrier permeability in mice [published correction appears in Sci Transl Med. 2014 Dec 10; 6(266):266er7. Guan, Ng Lai [corrected to Ng, Lai Guan]. Sci Transl Med. 2014;6(263):263ra158. doi:10.1126/scitranslmed.3009759

Stilling RM, van de Wouw M, Clarke G, Stanton C, Dinan TG, Cryan JF. The neuropharmacology of butyrate: The bread and butter of the mi-crobiota-gut-brain axis?. Neurochem Int. 2016; 99:110-132. doi:10.1016/j.neuint.2016.06.011

Geng S, Yang L, Cheng F, et al. Gut Microbiota Are Associated With Psychological Stress-Induced Defections in Intestinal and Blood-Brain Barriers. Front Microbiol. 2020; 10:3067. Published 2020 Jan 15. doi:10.3389/fmicb.2019.03067

Wand G. The influence of stress on the transition from drug use to addiction. Alcohol Res Health. 2008; 31(2):119-136.

McEwen BS, Nasca C, Gray JD. Stress Effects on Neuronal Structure: Hippocampus, Amygdala, and Prefrontal Cor-tex. Neuropsychopharmacology. 2016; 41(1):3-23. doi:10.1038/npp.2015.171

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How to Cite

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Reji RT, Ravi K, Sambath Kumar R. Assistance of Gut Microbiota in Depression. J. Drug Delivery Ther. [Internet]. 2021 Dec. 15 [cited 2026 Apr. 30];11(6-S):167-72. Available from: https://jddtonline.info/index.php/jddt/article/view/5202

How to Cite

1.
Reji RT, Ravi K, Sambath Kumar R. Assistance of Gut Microbiota in Depression. J. Drug Delivery Ther. [Internet]. 2021 Dec. 15 [cited 2026 Apr. 30];11(6-S):167-72. Available from: https://jddtonline.info/index.php/jddt/article/view/5202