Preparation and Characterization of Ethosomes for Topical Delivery of Clindamycin
Abstract
Topical medication administration is the simplest and most convenient method of delivering localised drugs to any part of the body via ophthalmic, rectal, vaginal, and cutaneous channels. These are used in a wide range of cosmetic and dermatological preparations on both healthy and sick skin. Drugs are applied topically to have an effect at the application site or to have systemic effects. The goal of this study was to develop and characterise clindamycin ethosomes that could carry the medicine to the target site more efficiently while also avoiding the complications associated with oral drug delivery. The formulations were tested for vesicle size, shape, and surface morphology, entrapment efficiency, and in vitro drug penetration using different amounts of ethanol (10-50 percent), HPMC (1-4 percent), and PVC (5-20 percent). Transmission electron microscopy and surface electron microscopy revealed ethosomes with an average size of 1.112m and a spherical shape with a smooth surface. The maximum percentage of ethosomes entrapped was 91.060.79%. The total amount of medication that pierced the biological membrane was found to be between 0.250.014 and 0.480.032 mg/cm2. The stability profile of the constructed system was evaluated for 45 days, and the results revealed that very little drug degradation occurred during storage.
Keywords: Clindamycin, Ethosomes, Topical delivery, HPMC, Acne, Vesicle size
Keywords:
Clindamycin, Ethosomes, Topical delivery, HPMC, Acne, Vesicle sizeDOI
https://doi.org/10.22270/jddt.v12i1.5190References
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