Formulation, Development and Evaluation of Ketoprofen Loaded Transethosomes Gel

Abstract

Ketoprofen ([RS]2-[3-benzoylphenyl]-propionic acid) is widely employed as a non-steroidal anti-inflammatory drug (NSAID). Ketoprofen is offered in a variety of forms in the pharmaceutical industry, including coated tablets, capsules, topical gels, transdermal patches, liquid spray, and injection solutions. The purpose of present work was to look at the possibility of transethosomes gel formulations for transdermal distribution of ketoprofen and to see effect of lipid concentration, ethanol concentration, drug concentration, and stirrer time affected the results. Vesicle size, surface charge, entrapment efficiency, and stability studies were employed to characterise transethosomes. The viscosity, pH, drug content, extrudability, spreadability, and in vitro drug diffusion studies were employed to characterise the transethosomes containing gel. The optimised formulation of transethosomes had an average vesicle size (nm), percent EE, and zeta potential (mV) of 135.65, 76.65, and -39.98, respectively. The prepared gel TG-12 had a viscosity of 3540±15cps, a percent assay of 99.05±0.45, an extrudability of 175±0.25g, and a spreadability of 13.65±0.35 (g.cm/sec), respectively. Employed the Franz diffusion cell method, in vitro drug release from transethosomes gel was measured and determined to be 99.12 percent in 10 hours. The liberate of drugs from transethosomes gel formulations was establish to be exceedingly consistent and regulated. The ketoprofen-loaded transethosomes formulation in the gel was refined, and it may now be employed as a topical medication for its non-steroidal anti-inflammatory effects. The findings revealed that transethosomes gel was a viable choice for transdermal medication administration with tailored and long-term release. It also improves the penetration of many medications through the skin.

Keywords: Transethosomes gel, Ketoprofen, Franz diffusion cell, NSAID