Evaluation of Antiasthamic Activity of Electrohomeopathy Formulation Pettorale on Experimental Animals
Abstract
Objective: The current study was planned to evaluate the antiasthamatic effect of Electrohomeopathic medicine Pettorale in various experimental models.
Methods: The antiasthmatic activity of Electrohomeopathic medicine Pettorale was studied on different experimental animals like histamine induced bronchospasm in guinea pig, haloperidol induced catalepsy in rats, egg albumin induced paw anaphylaxis in rats and milk induced leukocytosis in mice.
Conclusion: Preliminary phytochemical screening has revealed the presence of alkaloids, glycosides, carbohydrates, amino acids, proteins, steroids and terpenoids. Petorella exhibited best antihistaminic activity at the dose of 400 mg/kg. It inhibited haloperidol-induced catalepsy, increased leukocyte count and increased eosinophil count due to milk allergen. Antiasthmatic activity of Pettorale may be possible due to the membrane stabilising potential, suppression of antibody production and inhibition of antigen induced histamine release.
Keywords: Electrohomeopathy, Pettorale, catalepsy, asthma, histamine
Keywords:
Electrohomeopathy, Pettorale, catalepsy, asthma, histamine
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References
1. Leonard Bielory, M.D., and Kristin Lupoli, M.D. Herbal Interventions in Asthma and Allergy. Journal of Asthma, 1999; 36(1): 1-65. https://doi.org/10.3109/02770909909065150
2. Sabat P K. and Pradhan S. P. Evaluation of anti-inflammatory activity of Electrohomeopathic drug (spagyric essence) Angiotico -2 in rats. International Journal of Medical Science and Research. 2020; 2(2):20-22
3. Sureshbabu P, Siddalingamurty E, Sashidhara NL, Sooryanarayanarao B, Bhavya DC. A review on electrohomeopathic medicinal practice: origin, principles, medicinal plants used and its current status in India. European Journal of Medicinal Plants 2020; 8:31-47. https://doi.org/10.9734/ejmp/2020/v31i830257
4. Giddon APJ. "Stepping stones to electrohomeopathy." Count Mattie's system of medicine, 3rd edition, Count Matties remedies Depot, London, 1892
5. Prakash D. Khandagale and Abhijeet V. Puri. Evaluation of antiasthmatic activity of Caesalpinia bonducella [L.] Roxb. Seed. Journal of Drug Delivery & Therapeutics. 2019; 9(2-s):144-149.
6. Turner R.A., Screening methods in pharmacology, II. Academic Press, New York. 1971.
7. Taur DJ, Patil RN, Patil RY. Antiasthmatic related properties of Abrus precatorius leaves on various models. Journal of Traditional and Complementary Medicine. 2017; 10:1016. https://doi.org/10.1016/j.jtcme.2016.12.007
8. Limbasiya KK, Modi VR, Tirgar PR et al. Evaluation of Anti asthmatic activity of dried whole plant extract of Leucas aspera using various experimental animal models. International Journal of Phytopharmacology. 2012; 3(3):291-298.
9. Jain et al. Evaluation of the Antiasthmatic Activity of Methanolic Extract of Trigonella Foenum Graecum on Experimental Models of Bronchial Asthma. Journal of Drug Delivery & Therapeutics. 2020; 10(1):101-106 https://doi.org/10.22270/jddt.v10i1.3924
10. Pemminat S, Nair V, Dorababu P et al. Effect of ethanolic leaf extract of Ocimum sanctum on haloperidol induced catalepsy in albino mice. Indian Journal of Pharmacology.2007; 39: 87-89. https://doi.org/10.4103/0253-7613.32526
11. Mitra SK. Antiasthmatic and antianaphylactic effect of E-721B: A herbal formulation. Indian Journal of Pharmacology.1999; 31: 133-37.
12. Horn BR, Robin ED. Total eosinophil count in management of Bronchial asthma. New England Journal of Medicine. 1975; 292:1152-55. https://doi.org/10.1056/NEJM197505292922204
13. Ghanshyam Parmar, Kilambi Pundarikakshudu, R. Balaraman. Anti-anaphylactic and antiasthmatic activity of Euphorbia thymifolia L.on experimental animals, Journal of Trad and Complementary Medicine 2019; 9:60-65 https://doi.org/10.1016/j.jtcme.2018.03.002
14. Azman S, etal. Traditional Medicinal Plants Conferring Protection Against Ovalbumin-Induced Asthma in Experimental Animals: A Review, Journal of Asthma and Allergy 2021; 14:641-662 https://doi.org/10.2147/JAA.S296391
15. Leonard Bielory, M.D., and Kristin Lupoli, M.D., REVIEW ARTICLE Herbal Interventions in Asthma and Allergy, Journal of Asthma, 1999; 36(1):1-65. https://doi.org/10.3109/02770909909065150
16. Uvnas B. Mast cells and histamine release. Ind J Pharmacol.1969; 1:23-32.
17. Rathore C, Dutt K. R, Sahu S, Deb L. Antiasthmatic activity of the methanolic extract of Physalis angulata Linn. Journal of Medicinal Plants Research Vol. 2011; 5(22):5351-5355.
18. B. S. Nishchal etal. Effect of Tribulus terrestris on Haloperidol-induced Catalepsy in Mice , Indian Jouarnal of Pharmaceutical Sciences. 2014; 76(6):564-567.
19. Taur DJ, Patil RY. Different screening methods for asthma: A review, Journal of Pharmacy and Research, 2010; 3 (12):2828- 2830.
20. Kumar D. Bhujbal S. S, Deoda R. S, and Mudgade S. C., Bronchodilator activity of aqueous extract of stem bark of Ailanthus excelsa Roxb, Pharmacognosy Research. 2010; 2(2):102-106. https://doi.org/10.4103/0974-8490.62955
21. Mali R. G. and Dhake A.S. Evaluation of effects of Bauhinia variegata stem bark extracts against milk-induced eosinophilia in mice, Jouarnal of Advance Pharmaceutical Technology and Research. 2011; 2(2):132-134. https://doi.org/10.4103/2231-4040.82949
2. Sabat P K. and Pradhan S. P. Evaluation of anti-inflammatory activity of Electrohomeopathic drug (spagyric essence) Angiotico -2 in rats. International Journal of Medical Science and Research. 2020; 2(2):20-22
3. Sureshbabu P, Siddalingamurty E, Sashidhara NL, Sooryanarayanarao B, Bhavya DC. A review on electrohomeopathic medicinal practice: origin, principles, medicinal plants used and its current status in India. European Journal of Medicinal Plants 2020; 8:31-47. https://doi.org/10.9734/ejmp/2020/v31i830257
4. Giddon APJ. "Stepping stones to electrohomeopathy." Count Mattie's system of medicine, 3rd edition, Count Matties remedies Depot, London, 1892
5. Prakash D. Khandagale and Abhijeet V. Puri. Evaluation of antiasthmatic activity of Caesalpinia bonducella [L.] Roxb. Seed. Journal of Drug Delivery & Therapeutics. 2019; 9(2-s):144-149.
6. Turner R.A., Screening methods in pharmacology, II. Academic Press, New York. 1971.
7. Taur DJ, Patil RN, Patil RY. Antiasthmatic related properties of Abrus precatorius leaves on various models. Journal of Traditional and Complementary Medicine. 2017; 10:1016. https://doi.org/10.1016/j.jtcme.2016.12.007
8. Limbasiya KK, Modi VR, Tirgar PR et al. Evaluation of Anti asthmatic activity of dried whole plant extract of Leucas aspera using various experimental animal models. International Journal of Phytopharmacology. 2012; 3(3):291-298.
9. Jain et al. Evaluation of the Antiasthmatic Activity of Methanolic Extract of Trigonella Foenum Graecum on Experimental Models of Bronchial Asthma. Journal of Drug Delivery & Therapeutics. 2020; 10(1):101-106 https://doi.org/10.22270/jddt.v10i1.3924
10. Pemminat S, Nair V, Dorababu P et al. Effect of ethanolic leaf extract of Ocimum sanctum on haloperidol induced catalepsy in albino mice. Indian Journal of Pharmacology.2007; 39: 87-89. https://doi.org/10.4103/0253-7613.32526
11. Mitra SK. Antiasthmatic and antianaphylactic effect of E-721B: A herbal formulation. Indian Journal of Pharmacology.1999; 31: 133-37.
12. Horn BR, Robin ED. Total eosinophil count in management of Bronchial asthma. New England Journal of Medicine. 1975; 292:1152-55. https://doi.org/10.1056/NEJM197505292922204
13. Ghanshyam Parmar, Kilambi Pundarikakshudu, R. Balaraman. Anti-anaphylactic and antiasthmatic activity of Euphorbia thymifolia L.on experimental animals, Journal of Trad and Complementary Medicine 2019; 9:60-65 https://doi.org/10.1016/j.jtcme.2018.03.002
14. Azman S, etal. Traditional Medicinal Plants Conferring Protection Against Ovalbumin-Induced Asthma in Experimental Animals: A Review, Journal of Asthma and Allergy 2021; 14:641-662 https://doi.org/10.2147/JAA.S296391
15. Leonard Bielory, M.D., and Kristin Lupoli, M.D., REVIEW ARTICLE Herbal Interventions in Asthma and Allergy, Journal of Asthma, 1999; 36(1):1-65. https://doi.org/10.3109/02770909909065150
16. Uvnas B. Mast cells and histamine release. Ind J Pharmacol.1969; 1:23-32.
17. Rathore C, Dutt K. R, Sahu S, Deb L. Antiasthmatic activity of the methanolic extract of Physalis angulata Linn. Journal of Medicinal Plants Research Vol. 2011; 5(22):5351-5355.
18. B. S. Nishchal etal. Effect of Tribulus terrestris on Haloperidol-induced Catalepsy in Mice , Indian Jouarnal of Pharmaceutical Sciences. 2014; 76(6):564-567.
19. Taur DJ, Patil RY. Different screening methods for asthma: A review, Journal of Pharmacy and Research, 2010; 3 (12):2828- 2830.
20. Kumar D. Bhujbal S. S, Deoda R. S, and Mudgade S. C., Bronchodilator activity of aqueous extract of stem bark of Ailanthus excelsa Roxb, Pharmacognosy Research. 2010; 2(2):102-106. https://doi.org/10.4103/0974-8490.62955
21. Mali R. G. and Dhake A.S. Evaluation of effects of Bauhinia variegata stem bark extracts against milk-induced eosinophilia in mice, Jouarnal of Advance Pharmaceutical Technology and Research. 2011; 2(2):132-134. https://doi.org/10.4103/2231-4040.82949
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Sabat PK. Evaluation of Antiasthamic Activity of Electrohomeopathy Formulation Pettorale on Experimental Animals. JDDT [Internet]. 15Nov.2021 [cited 17Apr.2024];11(6):121-6. Available from: https://jddtonline.info/index.php/jddt/article/view/5165
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