A Recent Overview: In Situ Gel Smart Carriers for Ocular Drug Delivery
Abstract
Delivery of the drug to the ocular area is blocked by the protective layers covering the eyes; it has always been a major problem to find effective bioavailability of the active drug in the ocular area due to the short duration of precorneal majority ocular stay. Direct delivery systems combine as well as oil, solution, and suspension, as a result, many delivery systems are not able to effectively treat eye diseases. Many works have been done and are being done to overcome this problem one of which is to use in-situ to build polymeric systems. Ocular In-situ gelling systems are a new class of eye drug delivery systems that are initially in solution but are quickly transformed into a viscous gel when introduced or inserted into an ocular cavity where active drugs are released continuously. This sol-to-gel phase conversion depends on a variety of factors such as changes in pH, ion presence, and temperature changes. Post-transplanting gel selects viscosity and bio-adhesive properties, which prolongs the gel's stay in the ocular area and also releases the drug in a long and continuous way unlike conventional eye drops and ointments. This review is a brief overview of situ gels, the various methods of in situ gelling systems, the different types of polymers used in situ gels, their gel-based methods, and the polymeric testing of situ gel.
Keywords: In-situ gel, Polymers, and ion triggered in-situ gel, Mechanism, Evaluation parameters
Keywords:
In-situ gel, Polymers, ion triggered in-situ gel, Mechanism, Evaluation parametersDOI
https://doi.org/10.22270/jddt.v11i6-S.5147References
Tangri P, khurana S. Basics of ocular drug delivery systems. International Journal of Research Pharmaceutical Biomedical Science. 2011; 2(4): 1541-1552.
Patel A, Cholkar K, Agrahari V, Mitra AK. Ocular drug delivery system: An overview. World Journal Phamacol. 2013; 2(2):47-64. https://doi.org/10.5497/wjp.v2.i2.47
Basavaraj K, Nanjwade, Rucha V , Deshmukh, Kishori R , et al. Formation and evaluation of micro hydrogel of moxifloxacin hydrochloride. Eur J Drug Metab Pharmacokinet. 2012; (37):117-123. https://doi.org/10.1007/s13318-011-0070-9
Wu Y, Liu Y, Li X, Kebebe D, et al. Research progress of in-situ gelling ophthalmic drug delivery system. Asian Journal of Pharmaceutical Sciences. 2019; 14(1):1-15. https://doi.org/10.1016/j.ajps.2018.04.008
Basavaraj K, Nanjwade, Rucha V , Deshmukh, Kishori R , et al. Formation and evaluation of micro hydrogel of moxifloxacin hydrochloride. Eur J Drug Metab Pharmacokinet. 2012; (37):117-123. https://doi.org/10.1007/s13318-011-0070-9
Imperiale JC, Acosta GB, Sosnik A. Polymer- based carriers for ophthalmic drug delivery. Journal of controlled release. 2018; 285:106-141 https://doi.org/10.1016/j.jconrel.2018.06.031
Majeed A, Khan NA. Ocular in situ gel: An overview. Journal of Drug Delivery and Therapeutics. 2019; 9(1):337-347. https://doi.org/10.22270/jddt.v9i1.2231
Garge L, Ravindranath S. Ophthalmic PH sensitive in situ gel a review. Journal of Drug Delivery and Therapeutics. 2019; 9(2-s):682-689
Shivhare R, Pathak A, Shrivastava N, Singh C, Tiwari G, Goyal R. An update review on novel advanced ocular drug delivery system. World Journal of Pharmacy and Pharmaceutical Science. 2012; 1(2):545-568.
Gaudana R, Ananthula HK, Parenky, K.Mitra A. Ocular drug delivery. American Association of Pharmaceutical Scientists. 2010; 12(3):348-360. https://doi.org/10.1208/s12248-010-9183-3
J.Gaudana R, R. Gokulgandhi M, H.S Boddu S, K.Mitra A. Recent overview of ocular patients. Rec Patent Drug Delivery and Formulation. 2012; 6(2):95-106. https://doi.org/10.2174/187221112800672921
Sandeep DS, Narayana CR, Anoop NV, Smart in situ gels for glaucoma- An overview. Int. J. Pharm. Sci. Rev. Res. 2018; 50(1):94-100.
Arul KSG, Kumaran, Karthika K, Padmapreetha J. Int. J. of Pharmacy and Pharmaceutical Sciences. 2010; 2(4):1-5.
Patel H, Desai D, Karadia S, Prajapati D. Role of in situ gel in drug delivery system: A comprehensive review. Journal of Advancement in Pharmacology. 2021; 1(2):1-16.
Mali MN, Hajare AA. In-situ gel forming systems for sustained ocular drug delivery system. European Industrial Pharmacy. 2010; 5:17-20.
Patel J, Bhavsar B, Parikh S, Patel S. Ocular inserts-A potential ocular controlled drug delivery systems. Journal of Pharmaceutical Science and Medicine Research. 2021; 001(02):058-069. https://doi.org/10.53049/tjopam.2021.v001i02.010
Nirmal HB, Bakliwal SR, Pawar SP. In -situ gel new trends in controlled and sustained drug delivery system. International Journal Phartech Research. 2010; 2(2):1398-1408.
Podual K, Doyle III FJ, Peppas NA. Dynamic behavior of glucose oxidase-containing microparticles of poly (ethylene) - grafted cationic hydrogels in an environment of changing pH. Biomaterials. 2000; 21:1439-50 https://doi.org/10.1016/S0142-9612(00)00020-X
Shin SC, Kim JY, Oh IJ. Mucoadhesive and physicochemical characterization of Carbopol-Poloxamer gels containing triamcinolone acetonide. Drug Dev Ind Pharm. 2000; 26(3):307-12. https://doi.org/10.1081/DDC-100100358
Ganesh NS, Ashir TP, Vineeth C. Review on approaches and evaluation of in-situ gel ocular drug delivery system. International Research Journal of Pharmaceutical and Biosciences. 2017; 4(3):23-33.
Rathore KS. In-situ gelling ophthalmic drug delivery system: An overview. International Journal of Pharmacy and Pharmaceutical Science. 2010; 2(4):30-34.
Nagalakshmi S, Anbarasan B, Ramesh S, Shanmuganathan S, Thanka J. An overview-Stimuli sensitive Hydrogels in ocular drug delivery system. Journal of Pharmaceutical Science and Research. 2015; 7(10):818-822.
Cassano R, Di Gioia ML, Trombino S. Gel-based materials for ophthalmic drug delivery. Gels. 2021; 7(3):130. https://doi.org/10.3390/gels7030130
Achouri D, Alhanout K, Piccerelle P, Andrieu V. Recent advances in ocular drug delivery. Recent advances in ocular drug delivery. Drug Development and Industrial Pharmacy. 2012; 39(11):1-19. https://doi.org/10.3109/03639045.2012.736515
Rathore KS, Nema RK, Sisodia SS. An overview and advancement in ocular drug delivery. systems. IJPSR 2010; 1(10):11-23.
Wei G, Xu H, Ding PT, Li S M, Zheng J M J, Thermosetting Gels With Modulated Gelation Temperature For Ophthalmic Use. The Rheological and Gamma Scintigraphic Studies. J Controlled Rel. 2002; 83:64-65. https://doi.org/10.1016/S0168-3659(02)00175-X
Rajoria G, Gupta A. In-situ gelling System: A noval approach for ocular drug delivery. Am. J. Pharma. Tech. Res. 2012; 2(4):25-53.
Chhetri P, Chakraborty P, Das D, Afnan T. In-situ forming polymeric drug delivery systems for opthalamic use: An overeview. Journal of Drug Delivery and Therapeutic. 2021; 11(3-s):98-103. https://doi.org/10.22270/jddt.v11i3-S.4874
Aishwarya JJ, Sheetal BG, Ravindra BS. A review on nasal drug delivery system. World J Pharmacy and Pharm. Sci 2014; 3:231-54.
Prajapati N, Goyal A. A review: thermoreversible mucoadhesive in-situ gel. Int J Innovative Drug Discovery. 2013; 3:67-84.
Kavitha K, Santosh KP, M Rup, Jagadeesh S, et al. Recent development and strategies of ocular Insitu drug delivery system: A review. International Journal of Pharmaceutical and Clinical Research. 2013; 5(2):64-71.
Almeida H, Ameral MH, Lobão P, Sousa lobo JM. Application of poloxamers in ophthalmic pharmaceutical formulation: An overview. Expert Openion Drug delivery. 2013; 10(9):1223-1237. https://doi.org/10.1517/17425247.2013.796360
Kurniawansyah SI, Rusdiana T, Sopyan I, Subarnas A. A review on poloxamer and hydroxy propyl methyl cellulose combination as thermoresponsive polymers in noval ophthalmic in situ gel formulation and their characterization. Int. J. Applied Pharmaceutics. 2021; 13(1):27-31. https://doi.org/10.22159/ijap.2021v13i1.39697
Cabana A, Aı̈t-Kadi A, Juhász J, Study of the gelation process of polyethylene oxide a-polypropylene oxide b-polyethylene oxide a copolymer (Poloxamer 407) aqueous solutions, J. Colloid Interface Sci. 1997; 190(2):307-312. https://doi.org/10.1006/jcis.1997.4880
Kant A, Reddy S, Venkates JS et al. In situ gelling system-an overview. Pharmacol. Online. 2011; 2:28-44.
Irimia T, Dinu-Pirvu CE, Ghica M, et al. Chitosan-based in Insitu gels for ocular delivery of therapeutic: A state-of-the Art review. Marine Drugs. 2018; 16(10):373. https://doi.org/10.3390/md16100373
Rowe RC, Sheskey PJ, Quinn ME. Handbook of pharmaceutical Excipients. 6th ed. Amrican Pharmacists association: Pharmaceutical press; 2009.
Ludwig A. The use of mucoadhesive polymers in ocular drug delivery. Drug delivery review. 2005; 57(11):1595-1639. https://doi.org/10.1016/j.addr.2005.07.005
Mckenzie B, Key G. Eye gel for ophthalmic delivery. Expert Rev. Opthalmol. 2015; 10(2):127-133. https://doi.org/10.1586/17469899.2015.1015993
Mohanty D, Bakshi Dr K, Simharaju N, Haque MA, Sahoo CK. A Review on in situ gel: A Novel drug delivery system. Int. J. Pharm. Sci. Rev. Res. 2018; 50(1):175-181.
Rajeswari S, Prasanthi T, Sudha N, et al. Natural polymers: A recent review. World J. Pharmacy and Pharmaceutical Science. 2017; 6(8): 472-494. https://doi.org/10.20959/wjpps20178-9762
Shanmugam S, Manavalan R, Venkappayya D, Sundaramoorthy K. Natural polymers and their applications. Natural Product Radiance, 2005; 4(6):478-481.
Nokhodchi A, Raja S, Patel P, Asare-Addo K. The role of oral controlled release matrix tablets in drug delivery systems. Bioimpacts 2012; 2(4):175-185.
Tinu TS, Litha T, Kumar AB, Polymers used in Ophthalmic In Situ Gelling System, International Journal of Pharmaceutical Sciences Review and Research, 2013; 20(1):176-183.
Swapnil S. A review on polymers used in novel in situ gel formulation for ocular drug delivery and their evaluation. Journal of biological and scientific opinion 2003; 1(2):132-137. https://doi.org/10.7897/2321-6328.01221
Laddha UD, Mahajan HS, Patel RC. An insight to ocular in situ gelling systems. Int J Adv Pharm. 2017; 06(02):31-40.
Annex to the ICH Harmonised Tripartite Guidelines on stability testing of new drug substances and products. Q1A (R2) 2003.
Meshram S, Thorat S. Ocular In situ gel: Development evaluation and advancements. Sch. Acad. J. pharm. 2015; 4(7):340-346.
Khule MR, Vyavahare SB. A Review: In-Situ gel drug delivery system. Int. J. Res. Education and Scientific methods. 2021; 9(3):899-909.
Nerkar, T., Gujarathi, N. In situ gel: novel approach in sustained and controlled drug delivery system. Pharma science monitor, 2013; 4(4):1-18.
Nagare RB, Bhambere DS, Kumar RS, Kakad VK, Nagare SN. In Situ Gelling System: Smart Carriers for Ophthalmic Drug Delivery Int. J. Pharm. Res. Scholars. 2015; 4(2):10-23.
Kute PR, Gondkar SB, Saudagar RB. Ophthalmic in-situ gel: an overview. World J Pharmacy Pharm Science. 2015; 4:549-568.
Ramachandra LU, Vikas DG, Gadhave MV, Jadhav SL, Gaikwad DD. Design and development of pH-triggered in situ gelling system of Ciprofloxacin. Int. Res. J Pharmacy. 2012; 3(5):418-22.
Gupta C, Juyal V, Nagaich U. Formulation, optimization, and evaluation of in-situ gel of moxifloxacin hydrochloride for ophthalmic drug delivery. International Journal of Applied Pharmaceutics. 2019 Jul 7:147-58. https://doi.org/10.22159/ijap.2019v11i4.30388
Published
Abstract Display: 1346 
PDF Downloads: 866 PDF Downloads: 140 How to Cite
Issue
Section
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0). that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
How to Cite
.