Evaluation of Selected Flavonoids for the Anthelmintic and Skeletal Muscle Relaxant Activity using Animal Models

  • S Bala Yaswanth Kumar ⅤI Year Pharm.D, Kommareddy Venkata Sadasiva Rao Siddhartha College of Pharmaceutical Sciences, Vijayawada-520010, Andhra Pradesh, India https://orcid.org/0000-0002-9255-7361
  • Suranjan Bantupalli ⅤI Year Pharm.D, Kommareddy Venkata Sadasiva Rao Siddhartha College of Pharmaceutical Sciences, Vijayawada-520010, Andhra Pradesh, India https://orcid.org/0000-0001-6148-7180
  • Deekshit Atluri ⅤI Year Pharm.D, Kommareddy Venkata Sadasiva Rao Siddhartha College of Pharmaceutical Sciences, Vijayawada-520010, Andhra Pradesh, India https://orcid.org/0000-0002-5329-1476

Abstract

Most fruits and vegetables contain flavonoids, a type of phytonutrient. As well as carotenoids, they're responsible for fruits and vegetable brilliant hues. Some other phytonutrients such as flavonoids are strong antioxidants with anti-inflammatory and immune properties. There are many flavonoids, including anthocyanins, flavones, flavonols, flavonoids, and isoflavonoids. Quercetin and chrysin were chosen for the investigation. Humans and other animals can contract Helminthiasis (helminthiases), sometimes known as worm infection. Tapeworms, roundworms, and flukes are only a few of the parasites that exist. Skeletal muscle relaxants are used to treat spasticity caused by upper motor neuron syndromes and muscle discomfort or musculoskeletal spasms created by peripheral disturbances. Samples of quercetin and chrysin were generated in the presence of 0.5% SCMC suspension at concentrations of 10, 20, 30, and 40 mg/ml, and then analyzed. To keep track of photocell beam disruptions, a six-digit counter was utilized (locomotor activity). It was time to turn on the actophotometer and examine the locomotor behavior of each rat for five minutes. The basal activity levels of all the animals were recorded.


Keywords: Flavonoids, Anthelmintic, Skeletal Muscle relaxant, animal models

Keywords: Flavonoids, Anthelmintic, Skeletal Muscle relaxant, animal models

Downloads

Download data is not yet available.

Author Biographies

S Bala Yaswanth Kumar, ⅤI Year Pharm.D, Kommareddy Venkata Sadasiva Rao Siddhartha College of Pharmaceutical Sciences, Vijayawada-520010, Andhra Pradesh, India

I Year Pharm.D, Kommareddy Venkata Sadasiva Rao Siddhartha College of Pharmaceutical Sciences, Vijayawada-520010, Andhra Pradesh, India

Suranjan Bantupalli, ⅤI Year Pharm.D, Kommareddy Venkata Sadasiva Rao Siddhartha College of Pharmaceutical Sciences, Vijayawada-520010, Andhra Pradesh, India

I Year Pharm.D, Kommareddy Venkata Sadasiva Rao Siddhartha College of Pharmaceutical Sciences, Vijayawada-520010, Andhra Pradesh, India

Deekshit Atluri, ⅤI Year Pharm.D, Kommareddy Venkata Sadasiva Rao Siddhartha College of Pharmaceutical Sciences, Vijayawada-520010, Andhra Pradesh, India

I Year Pharm.D, Kommareddy Venkata Sadasiva Rao Siddhartha College of Pharmaceutical Sciences, Vijayawada-520010, Andhra Pradesh, India

References

1. Tirumalasetti J, Patel M, Shaikh U, Harini K, Shankar J. Evaluation of skeletal muscle relaxant activity of aqueous extract of Nerium oleander flowers in Albino rats. Indian journal of pharmacology, 2015; 47(4):409-413. https://doi.org/10.4103/0253-7613.161265.
2. Reddy D, Shindey S, Kilaru N B, Pingili R. Evaluation of skeletal muscle relaxant activity of quercetin and chrysin in Albino rats using rota-rod apparatus and actophotometer. Iranian Journal of Pharmacology and Therapeutics, 2017; 3.15(1):1-4. http://ijpt.iums.ac.ir/article-1-309-en.html
3. Swathi Krishna K V, Likitha E, Benzawada Yaswantha, Chiramana Umakavya, Komaragiri Usha Sri, Mulumudi Suneel, Sumanth T, & Vemuru Vamsi. Evaluation of Anti-Inflammatory Activity on Whole Plant of Aerva lanata (L.) by In-Vitro Methods. Future Journal of Pharmaceuticals and Health Sciences, 2021; 1(3):56-61.
4. Ubedulla S, Jayasree T, Chandra Sekhar N, Prakash M, samreen S, Shankar J. Evaluation of skeletal muscle relaxant activity of aqueous extract of Nerium oleander leaves in albino rats. International Journal of Biological & Pharmaceutical Research, 2014; 5:191-195.
5. Wantana Reanmongkol, Sanan Subhadhirasakul, Jarinee Kongsang, Malika Tanchong, Jutatip Kitti. Analgesic and Antipyretic Activities of n-Butanol Alkaloids Extracted from the Stem Bark Hunteria Zeylanica and its Major Constituent, Strictosidinic Acid, in Mice, Pharmaceutical Biology, 2000; 38(1):68-73, https://doi.org/10.1076/1388-0209(200001)3811-BFT068
6. Leewanich P, Tohda M, Matsumoto K, Subhadhirasakul S, Takayama H, Aimi N. Behavioral studies on alkaloids extracted from the leaves of Hunteria zeylanica. Biological Pharmaceutical Bulletin, 1996; 19:394–399. https://doi.org/10.1248/bpb.19.394
7. P Nagaveni, K Saravana Kumar, Y Ramesh, Pharmacognostic properties and analgesic activity studies of Abrus precatorius leaves, JITPS, 2012; 3(1):18-23.
8. Kozakowska M, Pietraszek-Gremplewicz K, Jozkowicz A, Dulak J. The role of oxidative stress in skeletal muscle injury and regeneration: Focus on antioxidant enzymes. Journal of Muscle Research and Cell Motility, 2015; 36:377–393. https://doi.org/10.1007/s10974-015-9438-9.
9. J. huang, X. zhu. The Molecular Mechanisms of Calpains Action on Skeletal Muscle Atrophy. Physiological Research, 2016; 65:547-560. https://doi.org/10.33549/physiolres.933087
10. Guardia T, Rotelli AE, Juarez AO, Pelzer LE. Anti-inflammatory properties of plant flavonoids. Effects of rutin, quercetin and hesperidin on adjuvant arthritis in rat. Farmaco. 2001; 56(9):683-7. https://doi.org/10.1016/s0014-827x(01)01111-9
11. Dash GK, Suresh P, Kar DM, Ganpaty S, Panda SB, Evaluation of Evolvulusalsinoides Linn. For anthelmintic and antimicrobial activities, Journal of Natural Remedies, 2002; 2:182 185. https://doi.org/10.18311/jnr/2002/146
Crossmark
Statistics
319 Views | 118 Downloads
How to Cite
1.
Bala Yaswanth Kumar S, Bantupalli S, Atluri D. Evaluation of Selected Flavonoids for the Anthelmintic and Skeletal Muscle Relaxant Activity using Animal Models. JDDT [Internet]. 15Nov.2021 [cited 18Apr.2024];11(6):127-34. Available from: https://jddtonline.info/index.php/jddt/article/view/5070