Association of Body Mass Index with Serum Vitamin D and PSA Levels among Sudanese Prostate Cancer Patients

  • Yousif Abdelhameed Mohammed Medial Laboratory Department, National Cancer Institute, University of Gezira, Wad Medani, Sudan
  • Ameer M Dafalla Molecular Biology Department National Cancer Institute, University of Gezira, Wad Medani, Sudan
  • Dafalla O Abuidris Oncology Department, National Cancer Institute, University of Gezira, Wad Medani, Sudan
  • Adam D. Abakar Department of Medical Parasitology, Faculty of Medical Laboratory Science, University of Gezira, Wad Medani, Sudan
  • A Mergani Molecular Biology Department National Cancer Institute, University of Gezira, Wad Medani, Sudan
  • Amira S. Khalafalla Department of Clinical Chemistry, Faculty of Medical Laboratory Science, University of Gezira, Wad Medani, Sudan
  • Abuagla M. Dafalla Department of Clinical Chemistry, Faculty of Medical Laboratory Science, University of Gezira, Wad Medani, Sudan
  • Mutaz I. Hassan Department of Clinical Chemistry, Faculty of Medical Laboratory Sciences, Shendi University, Sudan
  • Mohammed Abdelwahed Molecular Biology Department National Cancer Institute, University of Gezira, Wad Medani, Sudan

Abstract

Background: Prostate cancer is the second most common cancer in men worldwide and the second leading cause of cancer deaths in men in the United States. Obesity has been consistently associated with lower 25-hydroxyvitamin D (25(OH)D) concentrations.


Objectives: This cross-sectional study aimed to evaluate the serum vitamin D and PSA levels in Sudanese Obese and Non-Obese prostate cancer (PCa) attending the National Cancer Institute.


Patients and Methods: Eighty six prostate cancer patients were included in this study, they were identified by clinical examination, histopathology and prostate-specific antigen (PSA). The mean age of them was 71.78 ± 8.04 years. Serum Vitamin D and PSA were measured by Electrochemiluminescence (ECL) immunoassay reactions using (Cobase411, serial No: 0868-16, manufactured by Hitachi high technologies corporation, Tokyo-Japan) the Elecsys reagents kit (Roche – Germany)


Results: The means of serum vitamin D levels of among  obese was 35.5 ± 15.4 ng/dL and 38.4 ± 16.2 ng/dL  among non-obese group with non-significant differences(P=0.505). No significant association was observed between PSA levels and obese and non-obese (P=0.351). Vitamin D levels non-significantly negative correlated with BMI (r = -0.031, P = 0.778) and PSA (r = -0.062, P = 0.569), but there was insignificantly Positive correlated between PSA and vitamin D level (r = 0.151, P = 0.164).


Conclusion: insignificant differences between vitamin D and serum PSA with BMI, Oral supplementation is recommended for individuals with low level of vitamin D.


Keywords: Prostate cancer, Body mass index, Vitamin D, PSA, Sudanese.

Keywords: Prostate cancer, Body mass index, Vitamin D, PSA, Sudanese

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Author Biographies

Yousif Abdelhameed Mohammed, Medial Laboratory Department, National Cancer Institute, University of Gezira, Wad Medani, Sudan

Medial Laboratory Department, National Cancer Institute, University of Gezira, Wad Medani, Sudan

Ameer M Dafalla, Molecular Biology Department National Cancer Institute, University of Gezira, Wad Medani, Sudan

Molecular Biology Department National Cancer Institute, University of Gezira, Wad Medani, Sudan

Dafalla O Abuidris, Oncology Department, National Cancer Institute, University of Gezira, Wad Medani, Sudan

Oncology Department, National Cancer Institute, University of Gezira, Wad Medani, Sudan

Adam D. Abakar, Department of Medical Parasitology, Faculty of Medical Laboratory Science, University of Gezira, Wad Medani, Sudan

Department of Medical Parasitology, Faculty of Medical Laboratory Science, University of Gezira, Wad Medani, Sudan

A Mergani, Molecular Biology Department National Cancer Institute, University of Gezira, Wad Medani, Sudan

Molecular Biology Department National Cancer Institute, University of Gezira, Wad Medani, Sudan

Amira S. Khalafalla, Department of Clinical Chemistry, Faculty of Medical Laboratory Science, University of Gezira, Wad Medani, Sudan

Department of Clinical Chemistry, Faculty of Medical Laboratory Science, University of Gezira, Wad Medani, Sudan

Abuagla M. Dafalla, Department of Clinical Chemistry, Faculty of Medical Laboratory Science, University of Gezira, Wad Medani, Sudan

Department of Clinical Chemistry, Faculty of Medical Laboratory Science, University of Gezira, Wad Medani, Sudan

Mutaz I. Hassan, Department of Clinical Chemistry, Faculty of Medical Laboratory Sciences, Shendi University, Sudan

Department of Clinical Chemistry, Faculty of Medical Laboratory Sciences, Shendi University, Sudan

Mohammed Abdelwahed, Molecular Biology Department National Cancer Institute, University of Gezira, Wad Medani, Sudan

Molecular Biology Department National Cancer Institute, University of Gezira, Wad Medani, Sudan

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Mohammed YA, Dafalla AM, Abuidris DO, Abakar AD, Mergani A, Khalafalla AS, Dafalla AM, Hassan MI, Abdelwahed M. Association of Body Mass Index with Serum Vitamin D and PSA Levels among Sudanese Prostate Cancer Patients. JDDT [Internet]. 15Nov.2021 [cited 1Dec.2021];11(6):1-. Available from: https://jddtonline.info/index.php/jddt/article/view/5029

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