MODULATION OF GASTROINTESTINAL TRANSIT TIME OF SALBUTAAMOL SULPHATE BY FLOATING APPROCHES

Abstract

The present investigation concerns with the development and evaluation of the floating matrix tablets of Salbutmol Sulphate. Tablets were prepared by wet granulation method.  Hydroxypropyl methylcellulose and ethyl cellulose was used as a release retardant material. Sodium bicarbonate and Citric acid was incorporated as a gas-generating agent. The effects of Sodium bicarbonate and citric acid on drug release profile, floating properties and matrix integrity of tablet were investigated. Addition of Citric acid in excess amount results in disintegration of the tablet so the floating tablets are prepared by full 3² factorial designs by reducing the ratio of citric acid. Developed formulations were evaluated for their physical characteristics, drug content, floating lag time, floating duration, in vitro drug release profile etc. On the basis of various physical characteristics parameters it was found that all the formulations shows good result. On comparative kinetic modeling study such as (Zero order, Higuchi model and Korsmeyer-Peppas) it was found that all the formulations follow Higuchi model and correlation coefficient (R²) and Korsmeyer model values were nearer to unity. Among those formulations F8 and F9 showed R² value of Higuchi model more near as compared to the other formulation.

KEYWORDS: Salbutmol sulphate, Ethyl cellulose, HPMC, Sodium bicarbonate, Citric acid, Tartaric acid.