ANTIMICROBIAL PROFILE OF URINARY PATHOGENS TO DETERMINE EMPIRICAL THERAPY FOR URINARY TRACT INFECTIONS IN A RURAL TEACHING HOSPITAL OF WEST BENGAL.

Abstract

Background: Urinary tract infection (UTI) remains one of the common infections in OPD as well as hospitalized patients with significant morbidity. To acquire knowledge of pathogens and their antibiotic susceptibility pattern area specific studies are necessary to establish an appropriate empirical therapy. Aim: To see the drug resistance patterns of bacterial uropathogens to antimicrobials in our setting. Study design: One year ,Retrospective study ( March 2011 to February 2012) Material and methods: Sent sample from different OPD and IPD were processed by culture on CLED medium to isolate the organism/s. Different biochemical test were used to identify the organism/s. Antibiotic sensitivity testing(AST) were done on Muller Hinton agar by the Kirby Bauer disk diffusion method . The result of AST were analyzed. Results: E.coli (53.6%) was observed to be the predominant uropathogen followed by enterococcus (15.5%). Among fermentative Gram negative bacilli (GNB) commonly isolated E.coli showed maximum resistance to aminoglycosides eg gentamicin 53.6% , Fluroquinolones eg ciprofloxacin 64%, third generation cephalosporins ie ceftriaxone 62.9% and among Gram positive organisms ciprofloxacin resistance were as high as 40%. However imipenam was found to be most effective drug against  GNB followed by nitrofurantoin and Vancomycin agaist gram positive organisms followed by nitrofurantoin again . Conclusion : Nitrofurantoin found to be most useful antibiotic affective against both gram negative and gram positive organisms can be given orallyalso highlighting the main advantage of this drug .

Key words: Urinary tract infection (UTI), Uropathogens, Empirical treatement