Systematic Review of Plants Used Against Respiratory Diseases Related to COVID-19 in Africa
Abstract
Background: Respiratory disorders are known to affect the airways including the nasal passages, bronchi and lungs causing blockages. The advent of COVID-19 has further aggravated the complications of the respiratory systems where conventional medicine is not reachable or affordable by the majority poor in Africa. Hence, the over 80% of the African population who turn to traditional medicine for their primary health care.
Objective: This review is aimed to identify plants directed against respiratory diseases which can be useful in the fight against COVID-19.
Methodology: Scientific articles selected in this study span the last ten years (2011-2021). Keywords such as “ethnobotany in Africa”, “ethnobotany and respiratory diseases” “medicinal plants and respiratory diseases”, “traditional medicine and COVID-19” were searched in open access search engines such as: Science Direct, Research Gate, Google Scholar, Pubmed, Web of Science, Scopus. The ethnobotanical indices were then calculated using Microsoft excel to determine the plants with the most therapeutic potential to be considered for the local management of COVID-19.
Results: Data obtained were classified according to country of origin of the author of the publication, the botanical family and the respiratory pathology being treated. Thirteen (13) references were finally selected with the represented country being Benin Republic. One hundred and forty-three plant species belonging to 60 families were registered. The most recurrent families were the Fabaceae and Lamiaceae (18 citations each). The plants in these families were used for the management of fifteen diseases and / or symptoms relating to the respiratory system. The most cited plants were: Ocimum gratissimum L. (4 citations), Entandrophragma cylindrium (Sprague), Scyphocephalium ochocoa Warb., Rubia cordifolia and Allium sativum L. (3 citations each).
Conclusion: Based on the data obtained in this review Ocimum gratissimum stands out as the most used plant for the treatment of respiratory disorders.
Keywords: Respiratory diseases, Medicinal plants, COVID-19
Keywords:
Respiratory diseases, Medicinal plants, COVID-19DOI
https://doi.org/10.22270/jddt.v11i4-S.4957References
Ait-Khaled, N., Odhiambo, J., Pearce, N., Prevalence of symptoms of asthma, rhinitis and eczema in 13-14-year-old children in Africa: the international study of asthma and allergies in childhood phase III. Allergy 2007; 62(3) :247-258. https://doi.org/10.1111/j.1398-9995.2007.01325.x
Roth G. A. et al. Global, regional, and national age-sex-specific mortality for 282 causes of death in 195 countries and territories, 1980-2017: a systematic analysis for the Global Burden of Disease Study 2017. Lancet 2018; 392:1736-1788 https://doi.org/10.1016/S0140-6736(18)32203-7
Zhou F, Yu T, Du R, Fan G, Liu Y, Liu Z, Xiang J, Wang Y, Song B, Gu X, Guan L, Wei Y, Li H, Wu X, Xu J, Tu S, Zhang Y, Chen H, Cao B. Clinical course and riskfactors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study. Lancet 2020; 395:1054-62. https://doi.org/10.1016/S0140-6736(20)30566-3
Malik W et al. Emerging novel Coronavirus (2019-nCoV) - Current scenario, evolutionary perspective based on genome analysis and recent developments. Vet Q. 2020:40(1):1-12. https://doi.org/10.1080/01652176.2020.1727993
Rodríguez-Morales P, Going global - Travel and the 2019 novel coronavirus. Travel Med. Infect. Dis. 2019; 2020:33. https://doi.org/10.1016/j.tmaid.2020.101578
Sun J., He W-T, Wang L., Lai A., Ji X., Zhai X.L. COVID-19: epidemiology, evolution, and cross-disciplinary perspectives. Trends in Molecular Medicine, 2020; 26(5):483-496. https://doi.org/10.1016/j.molmed.2020.02.008
Fokouo Fogha J.V., Noubiap J.J. La lutte contre la COVID-19 au Cameroun nécessite un second souffle. Pan African Medical Journal; 2020; 37(1):14 https://doi.org/10.11604/pamj.supp.2020.37.1.23535
Khaerunnisa S, Kurniawan H, Awaluddin R, Suhartati S, Soetjipto S (2020) Potential inhibitor of COVID-19 main protease (Mpro) from several medicinal plant compounds by molecular docking study. Preprints 2020:2020030226 https://doi.org/10.20944/preprints202003.0226.v1
Kudi AC, Myint SH. Antiviral activity of some Nigerian medicinal plant extracts. J Ethnopharmacol 1999; 68(1-3):289-294. https://doi.org/10.1016/S0378-8741(99)00049-5
Pringproa K, Khonghiran O, Kunanoppadol S, Potha T, Chuammitri P. In vitro virucidal and virustatic properties of the crude extract of Cynodon dactylon against porcine reproductive and respiratory syndrome virus. Vet Med Int 2014. https://doi.org/10.1155/2014/947589
Ramalhete C, da Cruz FP, Mulhovo S, Sousa IJ, Fernandes MX, Prudencio M, et al. Dual-stage triterpenoids from an African medicinal plant targeting the malaria parasite. Bioorg Med Chem 2014; 22(15):3887-3890. https://doi.org/10.1016/j.bmc.2014.06.019
Ravikumar YS, Ray U, Nandhitha M, Perween A, Raja Naika H, Khanna N, Das S. Inhibition of hepatitis C virus replication by herbal extract: Phyllanthus amarus as potent natural source. Virus Research 2011; 158(1-2):89-97. https://doi.org/10.1016/j.virusres.2011.03.014
Xuan DT, Khanh DT. Chemistry and pharmacology of Bidens pilosa: an overview. Journal of Pharmaceutical Investigation 2016; 16. https://doi.org/10.1007/s40005-016-0231-6
Nigam M, Atanassova M, Mishra PA, Pezzani R, Devkota HP, Plygun S, Salehi B, Setzer W, Rad SJ. Bioactive compounds and health benefits of Artemisia Species. Natural Product Communications 2019; 1-17. https://doi.org/10.1177/1934578X19850354
Betti J.L. An ethnobotanical study of medicinal plants among the baka pygmies in the dja biosphere reserve, Cameroon. African Study Monographs, 2004; 25(1):1-27.
Chassagne F. (2017). Cancer du foie au Cambodge : état des lieux épidémiologiques, description des médecines traditionnelles utilisées et évaluation d'espèces médicinales sélectionnées. Thèse PhD, Université de Paul Sabatier Toulouse III, France.
Haidara M., Diarra M.L., Doumbia S., Denou A., Dembele D., Diarra A., Sanogo R. Plantes médicinales de l'Afrique de l'Ouest pour la prise en charge des affections respiratoires pouvant se manifester au cours de la Covid-19. Int. J. Biol. Chem. Sci. 2020; 14(8):2941-2950 https://doi.org/10.4314/ijbcs.v14i8.22
Kouchadé A.S., Adomou A.C., Tossou G.M., Yédomonhan H., Dassou G. H. et Akoègninou A. Étude ethnobotanique des plantes médicinales utilisées dans le traitement des maladies infantiles et vendues sur les marchés au sud du Bénin. Journal of Animal & Plant Sciences, 2016; 28(2):4418-4438
Mathouet H., Aboughe Angone S., Mengome L., Eyele Mve Mba C., Rondi M.L., Souza A., Lamidi M. Ethnobotanic study of plants used in traditional medicine for some respiratory affections in Gabon. ScienceLib Editions Mersenne: 2014; 6(140905). ISSN 2111-4706
Fatima E.H., Akka F.B., Dahmani J., Belahbib N., Zidane L. Étude ethnobotanique des plantes médicinales utilisées dans le traitement des infections du système respiratoire dans le plateau central marocain. Journal of Animal & Plant Sciences, 2015; 25(2):3886-3897
Helali A., Mokhtari C., Meriem Ghoul M., Belhadef M.S. (2020). Prevent COVID-19 infection: What place for medicinal plants according to the Algerian population? Algerian Journal of Pharmacy. 2020; 3(1).2602-795X
Mambe F.T., Voukeng I.K., Beng V.P., Kuete V. Antibacterial activities of methanol extracts from Alchornea cordifolia and four other Cameroonian plants against MDR phenotypes. Journal of Taibah University Medical Sciences 2015; 11(2):121-127 https://doi.org/10.1016/j.jtumed.2015.12.001
Watanabe Y, Kamioka Y, Seki M. Rhinovirus-Infected Patients in the COVID-19 Pandemic. Period Infection and Drug Resistance 2021; 14:609-611. https://doi.org/10.2147/IDR.S300001
Song WJ, Hui CKM, Hull JH, Birring SS, McGarvey L, Mazzone SB, Chung KF. Confronting COVID-19-associated cough and the post-COVID syndrome: role of viral neurotropism, neuroinflammation, and neuroimmune responses. Lancet Respir Med 2021; 9:533-44. https://doi.org/10.1016/S2213-2600(21)00125-9
Izquierdo JL, Almonacid C, González Y, Rio-Bermudez CD, Ancochea J, Cárdenas R, Lumbreras S, Soriano JB. The impact of COVID-19 on patients with asthma. Eur Respir J , 2021; 57:2003142. https://doi.org/10.1183/13993003.03142-2020
Kpètèhoto W.H., Hessou S., Tamègnon Dougnon V., Johnson R.C., Boni G., Houéto E.E., Assogba F., Pognon E., Loko F., Boko M., Gbénou J. Étude ethnobotanique, phytochimique et écotoxicologique de Ocimum gratissimum Linn (Lamiaceae) à Cotonou. Journal of Applied Biosciences, 2016; 109:10609-10617 ISSN 1997-5902 https://doi.org/10.4314/jab.v109i1.5
Ndjib R. C., Djova Steve Valdi, Amina Mamat, Kom Wayoué Christelle, Dibong Siegfried Didier and Nyegue Maximilienne Ascension In vitro antioxidant and anti-inflammatory activities of Alchornea cordifolia (Schumach & Thonn.) Müll.Arg. and Antrocaryon klaineanum Pierre extracts. International Journal of Botany: 2020; https://doi.org/10.22159/ijpps.2020v12i8.38272
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