Canagliflozin (Invokana®): a First-in-Class Anti-diabetic Drug
Abstract
The US Food and Drug Administration have approved (on March 29, 2013) a novel glucose-lowering agent, canagliflozin (Invokana, Janssen Pharmaceuticals) for the treatment of adults with type 2 diabetes. Canagliflozin is the first in a new class of drug, an oral inhibitor of sodium glucose cotransporter 2 (SGLT2). Inhibition of SGLT2 decreases glucose reabsorption in the renal tubule and increases urinary glucose excretion (UGE), with a consequent lowering of plasma glucose levels as well as weight loss.The profile of effective glucose lowering, weight loss, improved b-cell function, and low risk of hypoglycemia suggest that canagliflozin may be a clinically useful new antihyperglycemic agent.DOI
https://doi.org/10.22270/jddt.v3i3.490
Published
13-05-2013
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1.
Sen S. Canagliflozin (Invokana®): a First-in-Class Anti-diabetic Drug. J. Drug Delivery Ther. [Internet]. 2013 May 13 [cited 2025 Mar. 16];3(3):145-6. Available from: https://jddtonline.info/index.php/jddt/article/view/490
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Mini Review
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How to Cite
1.
Sen S. Canagliflozin (Invokana®): a First-in-Class Anti-diabetic Drug. J. Drug Delivery Ther. [Internet]. 2013 May 13 [cited 2025 Mar. 16];3(3):145-6. Available from: https://jddtonline.info/index.php/jddt/article/view/490
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