Formulation and In-Vitro Evaluation of Orally Disintegrating Tablets (ODTs) of Tramadol Hydrochloride
Abstract
Since orally disintegrating tablets (ODTs) of tramadol hydrochloride are not available in the market, so an attempt has been taken to formulate and evaluate ODT preparation of tramadol hydrochloride. In this present work, direct compression was the technique used for preparing ODT using superdisintegrants like croscarmellose sodium, sodium starch glycolate and crospovidone at different concentrations. Prepared formulations were evaluated for various quality parameters- angle of repose, Carr’s index, Hausner ratio, weight variation, friability, hardness, drug content, dispersion time, wetting time and in-vitro dissolution. The angle of repose data indicated that the flow property of all the formulations was good to excellent. Comparing with the specifications, the results of Carr's index (%) and Hausner’s ratio indicated that the flowability of all the formulations blend was significantly good. Prepared formulations showed average wetting time ranging from 40-45 seconds, average dispersion time with 3-6 minutes. In-vitro dissolution profile indicated the cumulative % drug release between 30-80% for most of the cases.
Keywords: Orally disintegrating tablets, Tramadol hydrochloride, Superdisintegrants, Direct compression.
Keywords:
Orally disintegrating tablets, Tramadol hydrochloride, Superdisintegrants, Direct compressionDOI
https://doi.org/10.22270/jddt.v11i3-S.4875References
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2. Roy A, Orodispersible tablets: A review, Asian Journal of Pharmaceutical and Clinical Research, 2016; 9(1):19-26.
3. Sharma V, Singh SP, Nama N, Khinchi MP, Formulation and evaluation of orally disintegrating tablet of lamotrigine, Asian Journal of Pharmaceutical Research and Development, 2017; 5(2):1-10.
4. Dey P, Maiti S, Orodispersible tablets: A new trend in drug delivery, Journal of Natural Science, Biology and Medicine, 2010; 1(1):2-5. DOI: https://dx.doi.org/10.4103%2F0976-9668.71663
5. Patil MG, Kakade SM, Pathade SG, Formulation and evaluation of orally disintegrating tablet containing tramadol hydrochloride by mass extrusion technique, Journal of Applied Pharmaceutical Science, 2011; 1(6):178-181.
6. Patel KB, Shete SN, Belgamwar VS, Tekade AR, Formulation design and optimization of taste-masked mouth-dissolving tablets of tramadol hydrochloride, Asian Journal of Pharmaceutics, 2010; 4(3):239-245. DOI: http://dx.doi.org/10.4103/0973-8398.72125
7. Shah RB, Tawakkul MA, Khan MA, Comparative evaluation of flow for pharmaceutical powders and granules, AAPS PharmSciTech. 2008; 9(1):250–258. DOI: https://doi.org/10.1208/s12249-008-9046-8
8. Remya KS, Beena P, Bijesh PV, Sheeba A, Formulation development, evaluation and comparative study of effects of super disintegrants in cefixime oral disintegrating tablets, Journal of Young Pharmacists, 2010; 2(3):234–239. DOI: https://dx.doi.org/10.4103%2F0975-1483.66794
9. Pawar H, Varkhade C, Jadhav P, Mehra K, Development and evaluation of orodispersible tablets using a natural polysaccharide isolated from Cassia tora seeds, Integrative Medicine Research, 2014; 3(2):91-98. DOI: https://doi.org/10.1016/j.imr.2014.03.002
10. Türkmen O, Şenyiğit ZA, Baloğlu E, Formulation and evaluation of fexofenadine hydrochloride orally disintegrating tablets for pediatric use, Journal of Drug Delivery Science and Technology, 2018; 43:201-210. DOI: http://doi.org/10.1016/j.jddst.2017.10.008
11. Ibrahim MA, Sayeh AE, Ela AE, Optimized furosemide taste masked orally disintegrating tablets, Saudi Pharmaceutical Journal, 2017; 25(7):1055-1062. DOI: https://dx.doi.org/10.1016%2Fj.jsps.2017.04.002
12. Dave V, Yadav RB, Ahuja R, Yadav S, Formulation design and optimization of novel fast dissolving tablet of chlorpheniramine maleate by using lyophilization techniques, Bulletin of Faculty of Pharmacy, Cairo University, 55(1):31-39. DOI: https://doi.org/10.1016/J.BFOPCU.2016.12.001
13. Shah SJ, Mazumder R, Formulation development and evaluation of mouth dissolving tablet of tramadol hydrochloride, Asian Journal of Pharmaceutical and Clinical Research, 2013; 6(7):31-36.
14. Puttewar TY, Kshirsagar MD, Chandewar AV, Chikhale RV, Formulation and evaluation of orodispersible tablet of taste masked doxylamine succinate using ion exchange resin, Journal of King Saud University-Science, 2010; 22(4):229-240. DOI: https://doi.org/10.1016/j.jksus.2010.05.003
15. Ponugoti RSR, Gonugunta CR, Formulation and evaluation of mouth dissolving tablets of tramadol hydrochloride. Tropical Journal of Pharmaceutical Research, 2014; 13(5):669-675. DOI: http://dx.doi.org/10.4314/tjpr.v13i5.3
16. Lachman L, Lieberman HA, Kanig JL. The theory and practice of industrial pharmacy. 3rd ed. Mumbai: Varghese Publishing House; 1987. P. 308.
2. Roy A, Orodispersible tablets: A review, Asian Journal of Pharmaceutical and Clinical Research, 2016; 9(1):19-26.
3. Sharma V, Singh SP, Nama N, Khinchi MP, Formulation and evaluation of orally disintegrating tablet of lamotrigine, Asian Journal of Pharmaceutical Research and Development, 2017; 5(2):1-10.
4. Dey P, Maiti S, Orodispersible tablets: A new trend in drug delivery, Journal of Natural Science, Biology and Medicine, 2010; 1(1):2-5. DOI: https://dx.doi.org/10.4103%2F0976-9668.71663
5. Patil MG, Kakade SM, Pathade SG, Formulation and evaluation of orally disintegrating tablet containing tramadol hydrochloride by mass extrusion technique, Journal of Applied Pharmaceutical Science, 2011; 1(6):178-181.
6. Patel KB, Shete SN, Belgamwar VS, Tekade AR, Formulation design and optimization of taste-masked mouth-dissolving tablets of tramadol hydrochloride, Asian Journal of Pharmaceutics, 2010; 4(3):239-245. DOI: http://dx.doi.org/10.4103/0973-8398.72125
7. Shah RB, Tawakkul MA, Khan MA, Comparative evaluation of flow for pharmaceutical powders and granules, AAPS PharmSciTech. 2008; 9(1):250–258. DOI: https://doi.org/10.1208/s12249-008-9046-8
8. Remya KS, Beena P, Bijesh PV, Sheeba A, Formulation development, evaluation and comparative study of effects of super disintegrants in cefixime oral disintegrating tablets, Journal of Young Pharmacists, 2010; 2(3):234–239. DOI: https://dx.doi.org/10.4103%2F0975-1483.66794
9. Pawar H, Varkhade C, Jadhav P, Mehra K, Development and evaluation of orodispersible tablets using a natural polysaccharide isolated from Cassia tora seeds, Integrative Medicine Research, 2014; 3(2):91-98. DOI: https://doi.org/10.1016/j.imr.2014.03.002
10. Türkmen O, Şenyiğit ZA, Baloğlu E, Formulation and evaluation of fexofenadine hydrochloride orally disintegrating tablets for pediatric use, Journal of Drug Delivery Science and Technology, 2018; 43:201-210. DOI: http://doi.org/10.1016/j.jddst.2017.10.008
11. Ibrahim MA, Sayeh AE, Ela AE, Optimized furosemide taste masked orally disintegrating tablets, Saudi Pharmaceutical Journal, 2017; 25(7):1055-1062. DOI: https://dx.doi.org/10.1016%2Fj.jsps.2017.04.002
12. Dave V, Yadav RB, Ahuja R, Yadav S, Formulation design and optimization of novel fast dissolving tablet of chlorpheniramine maleate by using lyophilization techniques, Bulletin of Faculty of Pharmacy, Cairo University, 55(1):31-39. DOI: https://doi.org/10.1016/J.BFOPCU.2016.12.001
13. Shah SJ, Mazumder R, Formulation development and evaluation of mouth dissolving tablet of tramadol hydrochloride, Asian Journal of Pharmaceutical and Clinical Research, 2013; 6(7):31-36.
14. Puttewar TY, Kshirsagar MD, Chandewar AV, Chikhale RV, Formulation and evaluation of orodispersible tablet of taste masked doxylamine succinate using ion exchange resin, Journal of King Saud University-Science, 2010; 22(4):229-240. DOI: https://doi.org/10.1016/j.jksus.2010.05.003
15. Ponugoti RSR, Gonugunta CR, Formulation and evaluation of mouth dissolving tablets of tramadol hydrochloride. Tropical Journal of Pharmaceutical Research, 2014; 13(5):669-675. DOI: http://dx.doi.org/10.4314/tjpr.v13i5.3
16. Lachman L, Lieberman HA, Kanig JL. The theory and practice of industrial pharmacy. 3rd ed. Mumbai: Varghese Publishing House; 1987. P. 308.
Published
2021-06-15
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Ahmed N, Akter J, Archie SR. Formulation and In-Vitro Evaluation of Orally Disintegrating Tablets (ODTs) of Tramadol Hydrochloride. J. Drug Delivery Ther. [Internet]. 2021 Jun. 15 [cited 2026 Jan. 21];11(3-S):1-6. Available from: https://jddtonline.info/index.php/jddt/article/view/4875
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How to Cite
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Ahmed N, Akter J, Archie SR. Formulation and In-Vitro Evaluation of Orally Disintegrating Tablets (ODTs) of Tramadol Hydrochloride. J. Drug Delivery Ther. [Internet]. 2021 Jun. 15 [cited 2026 Jan. 21];11(3-S):1-6. Available from: https://jddtonline.info/index.php/jddt/article/view/4875
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