Formulation and Evaluation of Lignocaine Hydrochloride Proniosomes Loaded Orabase for Dental Anaesthesia
Abstract
The aim of this research is to prepare and evaluate lignocaine HCl Proniosomal orabase for enhanced permeation and prolonged dental anaesthesia effect. Objective: Various lignocaine proniosomal gels were formulated employing various surfactants. Methods: The formulations were scrutinized for entrapment efficiency, optical microscopy, in-vitro diffusion and release studies, mucoadhesive strength, ex-vivo permeation studies and drug – excipient interactions were determined by FTIR spectroscopy. Results: span 80 was found to be superior and significant for loading in to orabase. Considering the best entrapment efficiency with span 80 (91.60%) and optimum vesicle shape, along with prolonged drug permeation (33.6% for 24 h) the formulation F4 was selected and optimized for loading into orabase. The formulation F4 loaded orabase exhibited significant prolonged release over 10 h, and permeation profiles exhibited nearly two – fold increased flux in comparison with control. Good mucoadhesive strength was observed for proniosomal orabase 6273dynes/cm2, No evidence of incompatibility amongst formulation components from FTIR studies. SEM images revealed the particle size range from 50 μmt to 100 μmt for proniosomal orabase. Conclusion: Orabase can be an effective carrier for proniosomes with enhanced retention time at the site of application and provide prolonged release for oro-dental conditions.
Keywords: lignocaine Hcl, Oro-dental anaesthesia, Proniosomal gel, Orabase, Entrapment efficiency, prolonged release.
Keywords:
lignocaine Hcl, Oro-dental anaesthesia, Proniosomal gel, Orabase, Entrapment efficiency, prolonged releaseDOI
https://doi.org/10.22270/jddt.v11i3-S.4866References
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