Formulation and Evaluation of Gastroretentive Floating Tablets of Quetiapine Fumarate
Abstract
The objective of the present study was to develop gastroretentive floating tablets of quetiapine fumarate. The gastroretentive floating tablets of quetiapine fumarate were formulated using natrosol 250 HHX as a sustained release polymer and sodium bicarbonate as a gas forming agents. A 32 factorial design was employed to study the influence of concentration of natrosol HHX 250 (X1) and concentration of sodium bicarbonate (X2) on the dependent variables % drug release at 1h (Y1), % drug release at 8 h (Y2) and floating lag time (Y3). The optimized formulation (O1) showed floating lag time 49 ± 3 sec and % drug release 99.54± 0.81 at 12 h. The in vitro release of F1-F9 batches were found in between 99.95 ± 1.18 % to 86.32 ±1.71 % at 12 h. Floating lag time of F1-F9 batches were found to be 25± 2 sec to 178 ± 3 sec. FTIR studies shown that there was no interaction between quetiapine fumarate and excipients. From the factorial design batches it was found that floating lag time was decreased with increasing the amount of sodium bicarbonate and decreasing the amount of natrosol 250 HHX. Here % release of drug was decreased with increase the extent of natrosol 250 HHX. The in-vitro release kinetics revealed Korsmeyer-Peppas model is followed and drug release is by anomalous diffusion.
Keywords: Quetiapine fumarate, Natrosol 250 HHX, Sodium bicarbonate, Gastroretentive floating tablets
Keywords:
Quetiapine fumarate, Natrosol 250 HHX, Sodium bicarbonate, Gastroretentive floating tabletsDOI
https://doi.org/10.22270/jddt.v11i3-S.4833References
Gharti KP, Thapa P, Budhathoki U, Bhargava A, Formulation and in vitro evaluation of floating tablets of hydroxypropyl methylcellulose and polyethylene oxide using ranitidine hydrochloride as a model drug, J Young Pharmacists 2012; 4(4):201-208. https://doi.org/10.4103/0975-1483.104363
Dehghan MH, Khan FN, Gastroretentive drug delivery systems: A patent perspective, Int J Health Res, 2009; 2(1):23-44. https://doi.org/10.4314/ijhr.v2i1.55385
Mathur P, Saroha K, Syan N, Verma S, Kumar V, Floating drug delivery systems: An innovative acceptable approach in gastroretentive drug delivery, Arch Apll Sci Res, 2010; 2:257-270.
Juthi AZ, Bithi TZ: Gastroretentive drug delivery technologies: review. World Journal of Pharmaceutical and Medical Research, 2018; 4(2):11-15.
Prajapati H, Patel K, Gupta AK, Formulation and evaluation of floating microspheres of baclofen, Int J Pharm Sci & Res, 2021; 12(3):1482-1494.
Amritha V., Kaur S , Pandey K, Formulation and in vitro evaluation of floating tablets of hydroxypropylmethylcellulose K4M and carbopol using metronidazole as model drug, International Journal of Pharmaceutical Science and Research, 2014; 5(6):2244-2249.
Yerikala R, Pudi V, Saravanakumar K, Vadhireddy S. Formulation and evaluation of floating drug delivery of cefotaxime using raft forming approach, Journal of Drug Delivery and Therapeutics, 2017; 7(4):110-119. https://doi.org/10.22270/jddt.v7i4.1473
Soni H, Ghulaxe C, Upadhyay S, Pillai S, Development and in vitro evaluation of an oral floating tablet of metronidazole, Journal of Drug Delivery and Therapeutics, 2018; 8(2):83-86. https://doi.org/10.22270/jddt.v8i2.1673
Kandukoori NR, Shanthi MS, Sushma J, Ramya C, Swapna M, Madhu G, Deepika B, Rao KNV, Dutt RK: A review on floating drug delivery system, World Journal of Pharmaceutical Research, 2017; 6(5):553-568. https://doi.org/10.20959/wjpr20175-8451
Someshwar K, Suryakanta S, Muddana E, Bhanoji R, Bikash RJ, Sambamoorthy U, Vishali D, QbD-based design and characterization of mucoadhesive microspheres of quetiapine fumarate with improved oral bioavailability and brain biodistribution potential. Bulletin of Faculty of Pharmacy, Cairo University, 2018; 56(2):129-145. https://doi.org/10.1016/j.bfopcu.2018.09.002
Figueroa, C, Brecher, M, Hamer-Maansson, JE, Winter H, Pharmacokinetic profiles of extended release quetiapine fumarate compared with quetiapine immediate release. Prog. Neuro-Psychopharmacol. Biol. Psych., 2009; 33(2):199-204. https://doi.org/10.1016/j.pnpbp.2008.09.026
Ukawala R, Singhvi G, Jain S, Shukla V, Yadav N, Sharma S. Design and characterization of controlled release gastro-retentive floating tablet of an atypical psychotropic agent, J Pharm Bioall Sci, 2012; 4(5):88-89. https://doi.org/10.4103/0975-7406.94151
Chandarana DA, Patel KS, Patel SC, Patel DR, Prajapati ST, Formulation and evaluation of mucoadhesive buccal tablets of carvedilol, Int J App Pharm, 2020; 12(4):170-181.
Poornima P, Abbulu K, Mukkanti K. Formulation and in-vitro evaluation of gastro-retentive floating tablets containing quetiapine fumarate. Int. J. Pharm. Sci. Drug Res., 2017; 9(6):315- 322. https://doi.org/10.25004/IJPSDR.2017.090605
Prajapati PH, Nakum VV, Patel CN. Formulation and evaluation of floating matrix tablet of stavudine. Int J Pharma Investig., 2012; 2(2): 83-89. https://doi.org/10.4103/2230-973X.100047
Pawar HA, Dhavale R, Development and evaluation of gastroretentive floating tablets of an antidepressant drug by thermoplastic granulation technique, Beni-Suef University Journal of Basic and Applied Sciences, 2014; 3(2):122-132. https://doi.org/10.1016/j.bjbas.2014.05.005
Patil M, Vidyasagar G, Patil VB, Formulation, optimization and evaluation of floating tablets clarithromycin. , Int J Pharm Pharm Sci, 2015; 7(5):320- 326.
Patel KS, Patel MB. Preparation and evaluation of chitosan microspheres containing nicorandil. Int J Pharma Investig 2014; 4(1):32-37. https://doi.org/10.4103/2230-973X.127738
Patel, D.M., Patel, D., Patel, A., Sheth, A., Shah, U.J. Method Development and Validation for Simultaneous Estimation of Benidipine Hydrochloride and Metoprolol Succinate in Tablet. Journal of Drug Delivery and Therapeutics. 2019; 9 (6s):28-33. https://doi.org/10.22270/jddt.v9i6-s.3692
Gambhire MN, Ambade KW, Kur mi SD, K adam VJ, Jadhav KR. Development and in vitro evaluation of an oral floating matrix tablet formulation of diltiazem hydrochloride. AAPS PharmSciTech 2007; 8(3):E73. https://doi.org/10.1208/pt0803073
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