Design, Development and Evaluation of Silk Based Film Forming Spray for Wound Healing

  • Vipul Wayal Department of Pharmaceutics, Aditya Bangalore Institute of Pharmacy Education & Research, Bangalore-560064, Karnataka, India. Affiliated to Rajiv Gandhi University of Health Sciences, Bangalore, Karnataka https://orcid.org/0000-0002-0950-5027
  • K. Nagasree Department of Pharmaceutics, Aditya Bangalore Institute of Pharmacy Education & Research, Bangalore-560064, Karnataka, India. Affiliated to Rajiv Gandhi University of Health Sciences, Bangalore, Karnataka
  • B. A. Vishwanath Department of Pharmaceutics, Aditya Bangalore Institute of Pharmacy Education & Research, Bangalore-560064, Karnataka, India. Affiliated to Rajiv Gandhi University of Health Sciences, Bangalore, Karnataka

Abstract

The objective of the present study is to formulate and evaluate Silk based film forming spray for wound healing. On the wound surface the solution solidifies into a film which can deliver the active moiety on site of action. The spray solution was prepared by simple mixing of active extract of Centella Asiatica, Silk Protein and various film forming polymers. Silk protein form scaffold for active fibroblast movement and Asiaticosides from Centella Asiatica extract improve and fasten collagen synthesis. A clear yellowish solution was obtained. The formulations (F1-F8) had a pH range between 5.5–6.5, which was close to the pH of skin. The viscosity of formulation in range of 25–50 cps, completely dry film formed within 5 min in open environment. The Effects of polymers, plasticizers and solvents on spreadability. Surface tension and Spray angle were studied. The high content of ethanol in the formulation fastens the drying time. The results indicated that formulation (F8) showed good spreadability and less drying time.


Keywords: Film forming spray, Wound healing, Silk protein, Asiaticoside, Scaffold

Keywords: Film forming spray, Wound healing, Silk protein, Asiaticoside, Scaffold

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Author Biographies

Vipul Wayal, Department of Pharmaceutics, Aditya Bangalore Institute of Pharmacy Education & Research, Bangalore-560064, Karnataka, India. Affiliated to Rajiv Gandhi University of Health Sciences, Bangalore, Karnataka

Department of Pharmaceutics, Aditya Bangalore Institute of Pharmacy Education & Research, Bangalore-560064, Karnataka, India. Affiliated to Rajiv Gandhi University of Health Sciences, Bangalore, Karnataka

K. Nagasree, Department of Pharmaceutics, Aditya Bangalore Institute of Pharmacy Education & Research, Bangalore-560064, Karnataka, India. Affiliated to Rajiv Gandhi University of Health Sciences, Bangalore, Karnataka

Department of Pharmaceutics, Aditya Bangalore Institute of Pharmacy Education & Research, Bangalore-560064, Karnataka, India. Affiliated to Rajiv Gandhi University of Health Sciences, Bangalore, Karnataka

B. A. Vishwanath, Department of Pharmaceutics, Aditya Bangalore Institute of Pharmacy Education & Research, Bangalore-560064, Karnataka, India. Affiliated to Rajiv Gandhi University of Health Sciences, Bangalore, Karnataka

Department of Pharmaceutics, Aditya Bangalore Institute of Pharmacy Education & Research, Bangalore-560064, Karnataka, India. Affiliated to Rajiv Gandhi University of Health Sciences, Bangalore, Karnataka

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Wayal V, Nagasree K, Vishwanath BA. Design, Development and Evaluation of Silk Based Film Forming Spray for Wound Healing. JDDT [Internet]. 15Jun.2021 [cited 29Jul.2021];11(3-S):15-8. Available from: https://jddtonline.info/index.php/jddt/article/view/4812