Enhancement of Solubility of Diclofenac Sodium by Pastillation Method
Abstract
The Diclofenac Sodium is BCS class II drug which comes under the antipyretic class drug, and has a wide range of use. But due to its low solubility it has low dissolution rate and hence reduced bioavailability. There are several methods for the enhancement of solubility and dissolution rate. Pastillation technique is widely employed in chemical industry for solidification and better handling. Pastilles are solidified discrete units, acquired directly from the melt mass. However, this method of pastillation has not been explored for the drug delivery system yet. Literature revels that it can be used as a novel, effective and easiest method for the enhancement of solubility and dissolution rate. The selection of polymer was done by the solubility studies and Kolliphor HS 15 was used to make the pastilles of Diclofenac Sodium. Formation of pastilles were confirmed by FT-IR and further evaluated for % yield, drug contents, solubility study and dissolution test. From the results it was concluded that, solubility of Diclofenac Sodium was increased by pastillation method by 2-fold and dissolution rate was also enhanced by double than that of the drug. Thus, pastillation can be an effective and easiest method to enhance the solubility, dissolution rate and bioavailability of poorly water-soluble drugs having good permeability.
Keywords: Diclofenac Sodium, Pastillation, Kolliphor HS 15, Solubility enhancement, Solid dispersion.
Keywords:
Diclofenac Sodium, Pastillation, Kolliphor HS 15, Solubility enhancement, Solid dispersionDOI
https://doi.org/10.22270/jddt.v11i2.4756References
Yellela S. R. K., “Pharmaceutical technologies for enhancing oral bioavailability of poorly soluble drugs,” Journal of Bioequivalence & Bioavailability. 2010; 2:28–36.
Sharma D., Soni M., Kumar S., Gupta G.D., “Solubility enhancement—eminent role in poorly soluble drugs, Research Journal of Pharmacy and Technology. 2009; 2:220–224.
Kumar A., Sahoo S.K., Padhee K., Kochar P.S., Sathapathy A., Pathak N., “Review on solubility enhancement techniques for hydrophobic drugs,” PharmacieGlobale.2011; 3:001–007.
Pandit. PA, Chavan TT, Khandelwal RK, Oral lipid based multipurticulat epastilles:design and effect of pore former; Journal of pharmaceutical investigation, 2015: 1-9.
Bajrachaiya R, Sang HL et al, Development of a Ternary solid dispersion formulation of LW6 to improve the invitro activity as BCRP inhibitor: prepration and in vitro/ in vivo characterization, 2019; 1-5.
Higuchi T., Conors KA., Phase solubility technique advance. Anal. Chem.Instr., 4,117-112.
Published
Abstract Display: 3507 
PDF Downloads: 1625 PDF Downloads: 1307 How to Cite
Issue
Section
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0). that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
How to Cite
.