Formulation and Evaluation of Liposome by Thin Film Hydration Method

Formulation of Liposome

  • Mahesh Umbarkar Department of Pharmaceutics, R.C. Patel Institute of Pharmaceutical Education and Research, Shirpur – 425 405, Maharashtra, India
  • Swapnil Thakare Department of Pharmaceutics, R.C. Patel Institute of Pharmaceutical Education and Research, Shirpur – 425 405, Maharashtra, India
  • Tanaji Surushe Department of Pharmaceutical Chemistry, MUP’s Collage of Pharmacy, Degaon – 444 506, Maharashtra, India
  • Amol Giri Department of Pharmaceutics, Samarth collage of Pharmacy, Deulgaon Raja – 443 204, Maharashtra, India
  • Vaibhav Chopade Department of Pharmaceutics, R.C. Patel Institute of Pharmaceutical Education and Research, Shirpur – 425 405, Maharashtra, India

Abstract

Liposomes are the most advance formulation for targeting and controlled drug delivery system. These liposomes are generally administered by intra-venous route. In this work the liposome was prepared by using thin film hydration method. The formulated liposome is evaluated or characterised by using zeta sizer, Encapsulation efficiency, Entrapment efficiency, In vitro drug release. Main things are drug which are used for formulation of liposome was Diclofenac sodium, it having anti-inflammatory and anti-pyretic effect. The Diclofenac sodium having several adverse effects, such as depression of renal function, Liver failure for repeated administration, Local mucosal irritation, gastritis. To avoid this adverse effect Diclofenac sodium are incorporate in liposomal formulation. By formulating liposomal formulation, the bioavailability of Diclofenac sodium increase. In conventional dosage form bioavailability of diclofenac sodium is 50℅. But in liposomal formulation bioavailability of this drug increase. The final result includes that diclofenac liposome formulation shows more sustained and prolong anti-inflammatory activity.


Keywords: Diclofenac sodium, Liposome, Anti-inflammatory activity.

Keywords: Diclofenac sodium, Liposome, Anti-inflammatory activity

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Author Biographies

Mahesh Umbarkar, Department of Pharmaceutics, R.C. Patel Institute of Pharmaceutical Education and Research, Shirpur – 425 405, Maharashtra, India

Department of Pharmaceutics, R.C. Patel Institute of Pharmaceutical Education and Research, Shirpur – 425 405, Maharashtra, India

Swapnil Thakare, Department of Pharmaceutics, R.C. Patel Institute of Pharmaceutical Education and Research, Shirpur – 425 405, Maharashtra, India

Department of Pharmaceutics, R.C. Patel Institute of Pharmaceutical Education and Research, Shirpur – 425 405, Maharashtra, India

Tanaji Surushe, Department of Pharmaceutical Chemistry, MUP’s Collage of Pharmacy, Degaon – 444 506, Maharashtra, India

Department of Pharmaceutical Chemistry, MUP’s Collage of Pharmacy, Degaon – 444 506, Maharashtra, India

Amol Giri, Department of Pharmaceutics, Samarth collage of Pharmacy, Deulgaon Raja – 443 204, Maharashtra, India

Department of Pharmaceutics, Samarth collage of Pharmacy, Deulgaon Raja – 443 204, Maharashtra, India

Vaibhav Chopade, Department of Pharmaceutics, R.C. Patel Institute of Pharmaceutical Education and Research, Shirpur – 425 405, Maharashtra, India

Department of Pharmaceutics, R.C. Patel Institute of Pharmaceutical Education and Research, Shirpur – 425 405, Maharashtra, India

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1.
Umbarkar M, Thakare S, Surushe T, Giri A, Chopade V. Formulation and Evaluation of Liposome by Thin Film Hydration Method. JDDT [Internet]. 15Jan.2021 [cited 28Sep.2021];11(1):72-6. Available from: https://jddtonline.info/index.php/jddt/article/view/4677