Development and Evaluation of Nutritious Supplementary Food Product in Phenyl Hydrazine Induced Anaemia in Wistar Rats

  • Dipali Hanamghar AISSMS College of Pharmacy, Kennedy Road, Pune 411001
  • Shivani Salokhe AISSMS College of Pharmacy, Kennedy Road, Pune 411001
  • Sachin Tembhurane Professor at AISSMS College of Pharmacy, Kennedy Road, Pune 411001
  • Swati Kolhe HOD of Pharmacology Department at AISSMS College of pharmacy, Kennedy Road, Pune 411001

Abstract

Objective- Nutritional deficiency anemia mainly results from a lack of iron, but it also associated due to lack of folate/vitamin B12 and low vitamin C intake. From various studies this is found anemia in people is due to poor eating habits, such as not eating enough fruits and legumes such as beans and peas. Proper nutritional supplementation may be useful in such condition. The aim of the present work was to select a suitable iron rich food material, and prepared a suitable dosage form for management of anaemic condition and to evaluate anti-anaemic potential of nutritious supplementary food. Method- Anemia was induced by phenyl-hydrazine. Animals were treated with nutritious supplementary food throughout the study for 30 days. The haemoglobin concentration was determined after 30 days. Results- Nutritious supplementary food was found to be rich in folic acid, ascorbic acid, and iron. Following the induction of anaemia, the haemoglobin concentration decreased by 30%. Administration of standard hematinic preparation and nutritious supplementary food 2gm/day in divided dose resulted in significant increase (P ≤ 0.05) in haemoglobin concentration when compared to the untreated phenyl hydrazine-induced anaemic rats. Conclusion- Nutritious supplementary food effectively raised the level of haemoglobin. Vitamin and minerals found in nutritious supplementary food are most likely active ingredients responsible for its hematinic effects.


Keywords- Anaemia, nutrition, nutritional anaemia, iron, phenyl hydrazine

Keywords: Anaemia, nutrition, nutritional anaemia, iron, phenyl hydrazine

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Author Biographies

Dipali Hanamghar, AISSMS College of Pharmacy, Kennedy Road, Pune 411001

AISSMS College of Pharmacy, Kennedy Road, Pune 411001

Shivani Salokhe, AISSMS College of Pharmacy, Kennedy Road, Pune 411001

AISSMS College of Pharmacy, Kennedy Road, Pune 411001

Sachin Tembhurane, Professor at AISSMS College of Pharmacy, Kennedy Road, Pune 411001

Professor at AISSMS College of Pharmacy, Kennedy Road, Pune 411001

Swati Kolhe, HOD of Pharmacology Department at AISSMS College of pharmacy, Kennedy Road, Pune 411001

HOD of Pharmacology Department at AISSMS College of pharmacy, Kennedy Road, Pune 411001

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1.
Hanamghar D, Salokhe S, Tembhurane S, Kolhe S. Development and Evaluation of Nutritious Supplementary Food Product in Phenyl Hydrazine Induced Anaemia in Wistar Rats. JDDT [Internet]. 15Jan.2021 [cited 28Sep.2021];11(1):68-1. Available from: https://jddtonline.info/index.php/jddt/article/view/4654