SIMULTANEOUS ESTIMATION OF SUMATRIRTAN SUCCINATE AND NAPROXEN SODIUM IN BULK DRUG AND PHARMACEUTICAL DOSAGE FORM BY RP-HPLC METHOD
Abstract
A simple, sensitive and rapid reverse phase high performance liquid chromatographic method was developed for simultaneous estimation of Sumatriptan succinate and Naproxen sodium. C18 column (250x 4.6 mm, 5μ) was used with a mobile phase containing a mixture Acetonitrile: Methanol: phosphate buffer in the ratio of 50:10:40 at pH 6.The flow rate was 1.0ml/min and effluents were monitored at 229 nm at flow rate of 1 ml/min. The retention time was found to be 4.037 min for Naproxen sodium and 2.813 min for Sumatriptan Succinate. Calibration curve was plotted with a range from 1-5μg/ml for Sumatriptan succinate and Naproxen sodium. The assay was validated for parameters like accuracy, precision, robustness and system suitability parameters. The proposed method can be useful in the routine analysis for determination on Sumatriptan succinate and Naproxen sodium.
Key words: Sumatriptan succinate, Naproxen sodium, Reverse Phase HPLC.
DOI
https://doi.org/10.22270/jddt.v3i2.463
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