Muco-adhesive buccal tablets of candesartan cilexetil for oral delivery: preparation, in-vitro and ex-vivo evaluation

  • Kumara Swamy Samanthula Vaagdevi Pharmacy College, Bollikunta, Warangal, Telangana, India
  • Agaiah Goud Bairi S.R.R College of Pharmaceutical Sciences, Valbhapur, Warangal, Telangana, India
  • CB Mahendra Kumar St. Mary's College of Pharmacy, Secunderabad, Telangana, India

Abstract

Candesartan cilexetil (CC) is an angiotensin II-receptor blocker (ARB). The antihypertensive effect of CC 4-16 mg/day was as great as that of other once-daily dosage regimens. Candesartan cilexetil has high first-pass metabolism and low oral bioavailability. The bioavailability of such drugs may be significantly improved if delivered through the buccal route; hence mucosal delivery is one of the alternative methods of systemic drug delivery. This study’s objective was to develop mucoadhesive buccal tablets of candesartan cilexetil using carbopol-934P, hydroxyl propyl methyl cellulose (HPMC), Eudragit RLPO, and sodium carboxy methyl cellulose (Na-CMC) as mucoadhesive polymers. Prepared CC buccal tablet formulations were evaluated for an optimized system based on physicochemical properties, ex-vivo residence time, in-vitro, and ex vivo permeation studies. The evaluation parameters of the tablets were within the acceptable Pharmacopoeial limits. However, the swelling and bio-adhesive time were increased with increasing polymer concentrations. The in-vitro release research shown that buccal tablets with sodium carboxy methyl cellulose (Na-CMC) exhibited a higher release than all other formulations and have been considered as optimized CC formulation. The release mechanism from kinetic methods suggests that the drug release follows zero-order kinetics with a diffusion mechanism. Further, in-vivo research in animal fashions is required to prove the bioavailability performance of the formulation.


Keywords: Candesartan cilexetil, mucoadhesive buccal tablets, first-pass metabolism, bioavailability.

Keywords: Candesartan cilexetil, mucoadhesive buccal tablets, first-pass metabolism, bioavailability

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Author Biographies

Kumara Swamy Samanthula, Vaagdevi Pharmacy College, Bollikunta, Warangal, Telangana, India

Vaagdevi Pharmacy College, Bollikunta, Warangal, Telangana, India

Agaiah Goud Bairi, S.R.R College of Pharmaceutical Sciences, Valbhapur, Warangal, Telangana, India

S.R.R College of Pharmaceutical Sciences, Valbhapur, Warangal, Telangana, India

CB Mahendra Kumar, St. Mary's College of Pharmacy, Secunderabad, Telangana, India

St. Mary's College of Pharmacy, Secunderabad, Telangana, India

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Samanthula KS, Bairi AG, Mahendra Kumar C. Muco-adhesive buccal tablets of candesartan cilexetil for oral delivery: preparation, in-vitro and ex-vivo evaluation. JDDT [Internet]. 15Feb.2021 [cited 28Sep.2021];11(1-s):35-2. Available from: https://jddtonline.info/index.php/jddt/article/view/4547