A Review A Review on Pharmacognostic and Therapeutic Uses of Rubia cordifolia
Abstract
In today’s time research on plants has increased globally. There are thousands of plant species having good potential offering direct therapeutic effect individually or in combinations. Manjith a herbal drug also known as Indian madder with its botanical name Rubia cordifolia is an age old ethno-medicinal plant in India used as anti-oxidant, anti-inflammatory, anticancer, anti-bacterial, anti-androgenic, immune-modulator, hepato-protective, astringent, tonic, antiseptic, de-obstruent, anti-dysenteric and efficient blood purifier, hence is extensively used against blood, skin and urinary diseases. This study is aimed at assessing the scientific evaluation of desi Rubia cordifolia in the course of pharmacognostical analysis to identify its various parts and to differentiate it from various adulterants, which mainly covers the macroscopic and microscopic features and its medicinal properties which are due to its richness in phytoconstituents such as quinines (anthraquinones), glycosides, saponins, tanins, alkaloids, hexapeptides, triterpenoids, steroids, phenols, and saccharids.
Keywords: Rubia cordifolia, Manjith, Fooh, ethno medicinal plant, Unani, pharmacological study
Keywords:
Rubia cordifolia, Manjith, Fooh, ethno medicinal plant, Unani, pharmacological studyDOI
https://doi.org/10.22270/jddt.v10i6.4514References
Verma A, Kumar B, Alam P, Singh V and Gupta SK, Rubia Cordifolia-A Review on Pharmaconosy and Phytochemistry, Int J Pharm Sci Res, 2016; 7(7): 2720-31.
McIntyre A, Monographs of Ayurvedic herbs commonly used in the treatment of children-Herbal treatment of children, 2005; 87-135.
Prajapathi ND and Kumar U, Dictionary of Medicinal Plants, Agrobios, Jodhpur, 2003; 294.
Sivarajan, VV and Balachandran, I, Ayurvedic Drugs and Their Plant Sources, Oxford & IBH Publishing Co. 1994.
Pandey BP, Taxonomy Anatomy Economic Botany & Embryology for Degree Students (S.Chand & Company Ltd., New Delhi) First edition, 1981; 183.
Kabiruddin AM, Makhzunul Mufradat, Delhi, Idara kitab ush shifa, 2007; 303.
Siva Rami Reddy E, A complete review on Rubia cordifoila, International J of Trend in Scientific Research and Develpoment, vol 2, Issue 2, ISSN N:2456-6470 www.ijtsrd.com
Bhatt NS, Deshpande M, Pharmacognostic studies on Identity of Manjishtha-Rubia cordifolia Linn- An Ayurvedic plant, IOSR Journal of Pharmacy Volume 5, Issue 3 2015; 06-12.
Jain SK and DeFillips RA, Medicinal Plants of India, Vol. 2. Reference Publications, Algonac, MI, 1991; 558.
Hooker JD, the Flora of British India, Vol III, L. Reeve & Co, London. 1882; 202- 204.
Kannan M, Singh and Narayanan, Phytochemistry and Immunopharmacological Investigation of Rubia cordifolia Linn. (Rubiaceae) Pharmacologyonline, 2009; 3: 653-662.
Deshkar N, Tilloo S and Pande V, Phcog Rev: Review Article a Comprehensive Review of Rubia cordifolia Linn. Pharmacognosy Reviews Vol 2, Issue 3, Jan-Jun, 2008.
Shethashok k, The herbs of Ayurveda, vol-4, 1st edition, 2005; 98.
More DB, Gajarmal AA and Shende MB, Comparitive studies of different samples of Manjishtha (Rubia cordifolia Linn) W.S.R. To Deshvichara-A Review, Int.J of Ayurveda and herbal medicine 2014; 4(5):1579-1584.
Devi PM and Siril EA, Pharmacognostic Studies on Indian Madder (Rubia cordifolia L.), Journal of Pharmacognosy and Phytochemistry, Vol. 1 No. 5 2013; 12. www.phytojournal.com
Bhat BA, Shergojri FA, Gaur M and Shammi QJ, A Comprehensive Review On Rubia Cardifolia (Manjistha), 2018. www.conferenceworld.in
Rubia root (Qiancao)-Rubia cordifolia-Radix Rubiae, 2012. www.epharmacognosy.com
Nabi MG, Makhzanul mufradat wa murakbat (Khaas Advia), Matba Iftekhar Delhi.
Kirtikar KR and Basu BD, Indian Medicinal Plants, Vol-2, Lalit Mohan Basu, Allahabad, 1981.
Singh BP, Dadich OP and Deepa, A review study of medicinal uses of Manjishtha (R. cordifolia), Int. J. Adv. Res. 5(8);1394-1401.
Antarkar DS, Bhatt N, Chinwalla T and Vaidya ADB, Indian Journal of Pharmaceutics, 1984; 15(3);185-188.
Bhatt P, Kushwah A, Rubia cordifolia Overview: A New Approach to Treat Cardiac Disorders, International Journal of Drug Development & Research, April 2013; 5:7-54.
Kabeeruddin H, Makhzanul Mufradat Khwas ul Advia, Sheikh Mohd Basheer and Sons, waqf Jalal Uddin building, chok Urdu bazar, Lahore, 417.
Joy J, Krishnan C and Nair K, Amelioration of cisplatin induced nephrotoxicity in Swiss albino mice by Rubia cordifolia extract, J of Cancer Res Ther, 2008; 4(3).
Bhardwaj HC and Jain KK, Indian dyes and dying industry in 18-19 century, Indian J of History of Science, 17(1):78-81.
Gogte VVM, Ayurvedic pharmacology and therapeutic uses of medicinal plants, Bharatiya Vidya Bhavan, Mumbai, 2000.
Razi Z, Kitab ul Hawi, vol 10, Central Council of Research in Unani Medicine, New Delhi, 52.
Ali HMS, Unani Advia Mufarredah 2010; 211.
Lateef HA, Qarabdine Mjeedi, Ajanta office and packaging limited, Delhi 1984; 123.
National Formulary of Unani Medicine vol 4th, Central Council of Research in Unani Medicine, Ministry of Health and Family Welfare, 2011; 68.
Kabiruddin HM, Moaljate Shareh Asbab, vol 2, Aijaz publication house, 2:176.
National Formulary of Unani Medicine Part 2nd vol 1st, Central Council of Research in Unani Medicine, Ministry of Health and Family Welfare, 2007; 68:71.
Meena V, Chaudharuy AK, Manjishtha (R.cordifolia) : A helping herb in cure of acne, Jour. of Ayurveda a holistic and Medicine, vol 3 Issue 2 EISSN: 3(2):2321-1563.
Khare CP, Encyclopedia of Indian Medicinal Plants, Springer, Germany, 2004; 405-406.
Kim KJ, Lee JS, Kwak MK, Choi HG, Yong CS, Kim JA, Lee YR, Lyoo WS and Park YJ: Anti-inflammatory action of mollugin and its synthetic derivatives in HT-29 human colonic epithelial cells is mediated through inhibition of NF-κB activation. European Journal of Pharmacology, 2009; 622:52-57.
Tsewang JT, Tibetan Medicinal plants, Tibetan medical publication, India, 1994; 132.
Wiart C, Ethnopharmacology of Medicinal plants-Asia and the Pacific, Human Press, New Jersey, 2006; 83-85.
Maithy, Folk uses of some medicinal plants from north Sikkim, Indian Journal of Traditional Knowledge, 2004; 69.
Bhosle SV, Ghule VP, Aundhe DJ, Jagtap SD, Ethenomedical Knowledge of plants used by the tribal people of Purandhar in Maharashtra India, Ethnobotanical leaflet, 2009; 13:1352-1361.
Thomas B, Rajendran A, Less known ethno medical plants used by kurichar tribe of Wayanad district, southern western ghats, Kerala, India, Botany Res. Int., 2013; 6:32-35.
Kar T, Mandal KK, Reddy CS, Biswal AK, Ethnomedicinal plants used to cure Diarrhoea, Dysentry and Cholera by some tribes of Mayurbhanj district, Odisha, India, Life Sci. leaflets, 2013; 2:18-28.
Padal SB, Raju JB, Chandrasekhar P, Traditional Knowledge of Konda Dora tribes, Visakhapatnam district, Andhra Pradesh, Indian Journal Pharmacy, 2013; 3: 23-28.
Bhatt D, Kumar R, Joshi GC, Tewari LM, Indigenous uses of medicinal plants by the Vanraji tribes of Kumaun Himalya, Indian Journal Medicinal Plants Res, 2013; 7:2747-2754.
Jayakumar G, Ajithabai MD, Sreedevi S, Vishwanathan PK, Keemsh kumar B, Ethnobotanical survey of the plants used in the treatment of diabetes, Indian Journal Traditional Knowledge, 2010; 9:100-104.
Singh P and SJ Ali, (Ethenomedicinal plants of family Rubiaceae of eastern U.P, Indian J.L.Sci., L,2012; 83-86.
Rubia+cordifolia, 2007. http://www.ibiblio.org/pfo.f/cgi-Bin/arr_html
Ssegawa P, Kasenene JM, Medicinal plant diversity and uses in the Sango bay area, Southern Uganda, J. Ethnopharmacology, Sep 25, 2007; 113(3):521-540.
Mishchenko NP, Fedoreev SA, Bryukhaov VM, Zverev YF, Lampatov VV, Azarova OV, Shkryl YN and Chernoded GK, Chemical Composition and Pharmacological Activity of Anthraquinones from Rubia cordifolia Cell Culture, Pharmaceutical Chemistry Journal, 2007; 41(11):605-609.
Itokawa H, Mihara K, Takeya K, Chem. Pharm. Bull, 1983; 31:2353-2358.
Singh N and Singh M, Preliminary Photochemical Investigation of Ethanolic and Petroleum Ether Extracts of Rubia cordifolia Leaves, Asian Journal of Pharmaceutical Education and Research ISSN: 2015; 4(3):2278-7496.
Dengre RG, Patel KN and Chauhan MB, Comparative studies of Rubia cordifoilia linn. And Rubia tinctorium linn (Rubiaece), Ancient Science of Life 13. Vol No. XIII Nos. 1 & 2, July-October 1993; 8(1):165-179.
Gupta PP, Srimal RC, Verma N and Toandon JS, Biological activity and isolation of an active principle, Pharm biology, 1999; 37(10):46-49.
Tripathi YB, Sharma M, Shukla S, Tripathi P, Thyagaraju K, Reddanna P, Rubia cordifolia inhibits potato lipoxygenase, Indian J. Exp. Biol., 995; 33:109-112.
Joharapurkar AA, Zambad SP, Wanjari MM and Umathe SN, In vivo evaluation of antioxidant activity of alcoholic extract of Rubia cordifolia linn. and its influence on ethanol-induced Immunosuppression, Indian Journal of Pharmacology 2003; 35:232-236.
Biswas TK, Mukherjee B, Roy JB, Plant medicines of Indian origin for wound healing activity: A review, Int. J. Low Extrem. Wounds, 2, 2003; 25-39.
Gupta M, Yadav SK, Singh D and Gupta N, Evaluation of wound healing activity of herbal drug combination of Rubia cordifolia, Centella Asiatica, Terminalia belerica, plumbago, Zeylanica and Withania Somnifera, International journal of Pharmaceutical and life science, 2011; 2(7):952-952.
Karodi R, Jadhav M, Rub R, Bafna A, Evaluation of the wound healing activity of a crude extract of Rubia cordifolia L. (Indian madder) in mice, Int. J. Applied Res.Natl. Products, 2009; 2:12-18.
Tripath YB, Sharma M, and Manickam M, Rubiadin a new antioxidant from Rubia cordifolia, Ind. J. Biochem. Biophys., 1997: 34:302-306.
Pawar AT, Kalyani D, Chandrasekar SB and Divakr G, Diuretic activity of root extract of Rubia cordifolia linn. Pharmacologyonline, 2009: 1:597-603.
Naidu KC, Lalram R, Bobbarala V, Antimicrobial agents from Rubia cordifolia and Glycyrrhiza glabra against pathogens of Gossypium, Int. J Pharma. Tech. Res., 2009; 1:1512-1518.
Mariselvam R, Ranjit Singh AJA, Nanthini AUR, Preparation and characterisation of Silver nanoparticles using Rubia cordifolia plant root extract and the microbial properties,Int.J Adv Res., 2013; 1:56-61.
Basu, Ghosh A, Hazra B, Evaluation of the antibacterial activity of Ventilago madraspatana Gaertn, Rubia cordifolia Linn. and Lantana camara Linn, Isolation of emodin and physcion as active antibacterial agents, Phytother Res., 2005; 19(10):888-94.
Qiao YF, Wang SX, Wu LJ, Li X, Zhu TR, Studies on antibacterial constituents from the roots of Rubia cordifolia L. Yao Hsueh Hsueh Pao (Acta Pharmaceutica Sinica), 1990; 25(11):834-9.
Tripathi YB, Pandey S, Shukla SD, Anti-platelet activating factor property of Rubia cordifolia Linn., Indian J. Exp. Biol., 1993; 31(6):533-5.
Tripathi YB, Singh AV, Role of Rubia cordifolia Linn in radiation protection, Indian J. of Experimental Biology, 2007; 45:620-625.
Shah V, Kumar S, Maurya DK, and Nair CKK, Protection of plasmid pBR322 DNA and membranes of rat liver microsome and mitochondria by Rubia cordifolia extract, Ind. J. Radiat. Re., 2004; 1:46.
Prajapati SN and Parmar KA, Anti-viral and in-vitro free radical scavenging activity of leaves of Rubia cordifolia, International Journal of Phytomedicine, 2011; 3:98-107.
Gupta M, Shaw BP and Mukerjee A, studies on Antipyretic-Analgesic and Ulcerative activity of polyherbal preparation in Rats and mice, Int.J. Pharmacol, 2008; 4:88-94.
Deoda RS, Kumar D, and Bhujbal SS, Gastroprotective effect of Rubia cordifolia Linn. on Aspirin plus Pylorus-ligated Ulcer, BMC Complem. Altern. M., 41624, 2011.
Pawar AT, Anap MP, Ghodasara JV and Kuchekar BS, Protective Effect of Hydroalcoholic Root Extract of Rubia cordifolia in Indomethacin-Induced Enterocolitis in Rats, Indian J Pharm Sci, 2011; 73(2):250–253.
Kasture VS, Deshmukh VK and Chopde CT, Anti convulscent and behavioural action of triterpene isolated from Rubia cordifolia linn, Indian J.Exp.Biol., 2008; 38:675-680.
Aslam M, Imtiyaz S, Tariq M, Chaudhary SS, Ahmed K, Unani immunomodulating Drugs: An overview, Int.J. Med. Pharm. Sci. Res. Review, 2013; 1-10.
Pandey S, Sharma M, Chatyrvedi P, Tripathi YB, Protective effect of RC on lipid peroxide formation in isolated rat liver homogenate, Ind. Journal of Experimental Biology, 1994; 32(3):180.
Tripathi YB, Sharma M, The interaction of RC with iron redox status A mechanistic aspect in 42. free radical reactions, Phytomedicine, 1999; 6(1): 51-57.
Patil R, Gadakh R, Gound H, Kasture S, Antioxidant and Anticholinergic Activity of Rubia Cordifolia, Pharmacologyonline, 2011; 2:272-278.
Tripathi YB, Shukla S, Sharma M, Shukla VK, Antioxidant property of Rubia cordifolia extract and its comparison with vitamin E and parabenzoquinone, Phytother. Res., 1995; 9:440–443.
Garle AM, Patil SS, Evaluation of antioxidant and Anti Acne property of R cordifolia, Der Pharmacia Sinica, 2010; 1(3):59-63.
Jain A, Bansal E, Inhibiton of propionibacterium acnes-induced mediators of inflammation by Indian herbs, phytomedicine, 2003; 10:34-38.
Zhang ZH, Clinical observation on the increase of leukocyte count in leukopenia promoted by diethylester Rubia cordifolia Linn, Zhong Xi Yi Jie He Za Zhi, 1983; 3(2):98-9.
Adwankar MK and Chitnis MP, In vivo anti-cancer activity of RC-18: A plant isolate from Rubia cordifolia Linn. against a spectrum of experimental tumour models, Chemotherapy 1982; 28(4):291-293.
Chang LC, ChaÂvez D, Gills JJ, Fong HHS, Pezzuto JM and Kinghorn AD, Rubiasins A-C, new anthracene derivatives from the roots and stems of Rubia cordifolia, Tetrahedron Letters, 2000; 41(37):7157-7162.
Patel PR, Raval BP, Karanth HA and Patel VR, Potent antitumor activity of Rubia cordifolia, International Journal of Phytomedicine, 2010; 2:44-46.
Gupta PP, Srimal RC, Verma N, Tandon JS, Biological Activity of Rubia cordifolia and Isolation of an Active Principle, Pharmaceutical Biology, 1999; 37(1):46-49.
SON JK, JUNG SJ, JUNG JH, FANG Z, LEE CS, SEO CS, MOON DC, MIN BS, KIM MR and WOO MH, Anticancer Constituents from the Roots of Rubia cordifolia L, Chem. Pharm. Bull, 2008; 56(2):213-216.
Gilani AH, Janbaz KH, Effect of Rubia cordifolia extract on acetaminophen and CCl4-induced hepatotoxicity, Phytotherapy Research, 1995; 9(5):372-375.
Babita MH, Chhaya G, Goldee P, Hepatoprotective activity of Rubia cordifolia, pharmacologyonline, 2007; 3:73-79.
Rao GM, Rao CV, Pushpangadan P, Shirwaikar A, Hepatoprotective effects of rubiadin, a major constituent of Rubia cordifolia Linn., J Ethnopharmacol, 2006; 103(3):484-90.
Paarakh PM, Sreeram DC, SD S, PS SG, AB V, In vitro Antiproliferative and in silico acytivity of Rubiadin isolated from roots of Rubia Cordifolia, Mintage J. of Pharmaceutical and medical sciences, 2016; 5(1).
Zhou LL, Lin ZX, Fung KP, Che CT, Zhao M, Cheng CHK, Zuo Z, Ethyl acetate fraction of Radix rubiae inhibits cell growth and promotes terminal differentiation in cultured human keratinocytes, Journal of Ethnopharmacology, 2012; 142: 241-247.
Patil RA, Jagdale SC, Kasture SB, Antihyperglycemic, Antistress and Nootropic activity of roots of Rubia cordifolia linn, Ind. J. Exp. Biol., 2006; 44:987-992.
Somani SR, Jain SK, Singhai AK, Hypoglycaemic activity of roots of rubia cordifolia in normal and diabetic rats, Pharmacologyonline, 2007; 1:162-169.
Viswanathaswamy AHM, Koti BC, Singh AK, Thippeswamy AHM, Antihyperglycemic and antihyperlipidemic effect of Rubia cordifolia leaf extract on Alloxan-induced Diabetes, RJPS, 2011; 1:49-52.
Divakar K, Pawar AT, Chandrasekhar SB, Dighe SB, Divakar G, Protective effect of the hydro-alcoholic extract of Rubia cordifolia roots against ethylene glycol induced urolithiasis in rats, Food Chem Toxicol, 2010; 48(4):1013-1018.
Gilani AH, Janbaz KH, Zaman M, Lateef A, Suria A, Ahmed HR, Possible presence of calcium channel blocker(s) in Rubia cordifolia: An indigenous medicinal plant, J Pak Med Assoc., 1994; 44(4): 82- 85.
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