Formulation and Evaluation of Ketorolac Tromethamine Mouth Dissolving Tablets

  • Rishabh Bindal Sri Aurobindo Institute of Pharmacy, Indore, Madhya Pradesh (India) 453555
  • Arpna Indurkhya Sri Aurobindo Institute of Pharmacy, Indore, Madhya Pradesh (India) 453555

Abstract

Due to more versatility and comfort, mouth dissolving tablets are the most advanced type of oral solid dosage forms. Compared to conventional tablets, it increases the effectiveness of APIs by dissolving within a minute in the oral cavity after contact with less saliva, without chewing and without the need for water for administration. Mouth Dissolving Tablets of Ketorolac tromethamine were prepared by direct compression method using various superdisintegrants like crospovidone, Croscarmellose sodium, and Sodium starch glycolate in different concentrations. Prepared tablets were evaluated for hardness, friability, weight variation, disintegration time, wetting time and in vitro drug release. Results of pre-compression and post-compression studies of all formulations were found within the standard limits. The tablets of all the batches were found to release more than 80% of drug in 5 minutes, which is the desired quality of mouth dissolving tablets that helps in faster absorption of the drug and quick onset of therapeutic effect. The the order of dissolution of various disintegrants was found to be Crospovidone˃ SSG˃ CCS. There was no significant variation in drug content of drug during stability studies for selected batch F3 in accelerated conditions over three months. It was concluded from the study that fast release of Ketorolac tromethamine from formulation F3 may reduce onset of drug action with better patient compliance.


Keywords: Crospovidone, Croscarmellose sodium, Ketorolac tromethamine, Mouth dissolving tablets, Sodium starch glycolate, superdisintegrants.

Keywords: Crospovidone, Croscarmellose sodium, Ketorolac tromethamine, Mouth dissolving tablets, Sodium starch glycolate, superdisintegrants

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Author Biographies

Rishabh Bindal, Sri Aurobindo Institute of Pharmacy, Indore, Madhya Pradesh (India) 453555

Sri Aurobindo Institute of Pharmacy, Indore, Madhya Pradesh (India) 453555

Arpna Indurkhya, Sri Aurobindo Institute of Pharmacy, Indore, Madhya Pradesh (India) 453555

Sri Aurobindo Institute of Pharmacy, Indore, Madhya Pradesh (India) 453555

References

1. Parashar AK, Kakde D, Chadhar V, Devaliya R, Shrivastav V, Jain UK, “A review on Solid Lipid Nanoparticles (SLN) for controlled and targeted delivery of medicinal agents” CRPS online, 2011; 31: 37-47.
2. Rathore R, Gupta AK, Parashar AK, “Formulation and Evaluation of fast dissolving films of Granisetron Hydrochloride” Journal of Drug Delivery and Therapeutics, 2019; 9(2-A): 36-38.
3. Tiwari G, Tiwari R, Sriwastawa B, “Drug delivery systems: An updated review” IJPI, 2012; 2(1): 2-11.
4. Ghosh T, Ghosh, A, Prasad D, “A review on new generation orodispersible tablets and its future prospective” IJPPS, 2010; 3(1): 1-7.
5. Earle RR, Ayalasomayajula LU, Raju AN, Kumari KT, Kumar PR, “Formulation and evaluation of diclofenac sodium orodispersible tablets using different superdisintegrants by direct compression technique” Der Pharmacia Lettre, 2016; 8(8): 227-238.
6. Santosh RK, Kumari A, “Fast dissolving tablets: waterless patient compliance dosage forms” Journal of Drug Delivery and Therapeutics, 2019; 9(1): 303-317. DOI https://doi.org/10.22270/jddt.v9i1.2292
7. Malang M, Jain N, Koshta A, Malviya S, Kharia A. “Formulation and evaluation of fast dissolving tablet of paracetamol and chlorpheniramine maleate” IJPSR, 2020; 11(3): 1232-42.
8. Sangeetha G, Mahesh PG, Chanthin K, Lokesh M, Ameen S, “Formulation and evaluation of fast dissolving tablet of ketorolac tromethamine” AJPCR, 2018; 11: 163-9.
9. Raina B, Sharma A, Bajwa PS, “Formulation evaluation and optimization of fast disintegrating tablets of ketorolac tromethamine” JPI, 2018; 48: 685-695.
10. Haranath, “Formulation and optimization of ketorolac tromethamine HCl fast disintegrating tablets by experimental design” IRJP, 2019; 10(7): 79-86.
11. Santosh RK, Kumari A, “Superdisintegrant: crucial elements for mouth dissolving tablets” Journal of Drug Delivery and Therapeutics, 2019; 9(2): 461-468. DOI https://doi.org/10.22270/jddt.v9i2.2480
12. Pawar C, Mutha SS, Bhise SV, Borawake PD, “Formulation and evaluation of mouth dissolving tablet of meloxicam using natural superdisintegrants. AJPCR, 2020; 13(2): 197-03.
13. Gamal M, Zayed AS, Rasoulae M, Ibrahimac M, “In vitro and in vivo characterization of domperidone-loaded fast dissolving buccal films” SPJ, 2020; 28(3): 266-273.
14. Damodar R, Movva B, Mallikarjun PN, Chaitanya P, Kona N, Varsha PV, “Formulation and evaluation of fast dissolving tablets of diclofenac sodium by novel hole technology” Mol Pharm Org Process Res, 2014; 2: 1-6.
15. Ratnaparkhi MP, “Formulation and development of taste masked orally disintegrating tablets of perindopril erbumine by direct compression method” PAA, 2012; 3:162-172.
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1.
Bindal R, Indurkhya A. Formulation and Evaluation of Ketorolac Tromethamine Mouth Dissolving Tablets. JDDT [Internet]. 15Jan.2021 [cited 28Sep.2021];11(1):60-4. Available from: https://jddtonline.info/index.php/jddt/article/view/4502