A Comprehensive Review on Floating Drug Delivery System (FDDS)
The main goal of any drug delivery system is to achieve desired concentration of the drug in blood or tissue, which is therapeutically effective and non-toxic for a prolonged period. Current pharmaceutical scenario focuses on the formulation of floating drug delivery system (FDDS). FDDS are low density systems that float over the gastric contents and remain buoyant in the stomach for a prolonged period of time without affecting the gastric emptying rate. The aim of writing this review is to compile the current literature with special focus on the principal mechanism of floatation to attain gastric retention. Effervescent FDDS release CO2 gas, thus reduce the density of the system and remain buoyant in the stomach for a prolonged period of time and released the drug slowly at a desired rate so it can be used to prolong the gastric residence time in order to improve the bioavailability of drug. The review briefly describes the mechanism, types of floating system, advantages, limitation, factors affecting floating system, drug candidates suitable for floating, evaluation parameters and application of the system. These systems are useful to several problems encountered during the development of a pharmaceutical dosage form and the future potential of FDDS.
Keywords: Floating drug delivery system, Absorption Window, Effervescent system, floating lag time.
2) Baviskar P, Patil P, Saudagar RB, Floating Drug Delivery System: A Comprehensive review, Journal of drug delivery and therapeutics, 2019; 9(3-s): 839-846. DOI https://doi.org/10.22270/jddt.v9i3-s.2945
3) Sharma AR, Khan A, Gastroretentive drug delivery system: An apporch to enchance gastric retention for prolonged drug release, IJPSR, 2014; 5(4):1095-1106.
4) Ninan S, John Wesley I, Kumaran J, Aparna P, Jaghatha T, A Review on Floating Drug Delivery System, Wjpmr, 2018; 4(5):275-281.
5) Vedha Hari B.N.et al, The Recent Developments on Gastric Floating Drug Delivery Systems: An overview, Int .J. PharmTech Res, 2010; 2(1):524-534.
6) Kotreka UK, Adeyeye MC, Gastroretentive Floating Drug-Delivery Systems: A Critical Review, Critical ReviewsTM in Therapeutic Drug Carrier Systems, 2011; 28(1):47-99.
7) Kumar N, Niranjan SK, Irchhaiya R, Verma V, Kumar V, Novel Approches of Floating Drug Delivery Systems: A Review, IJPRS, 2012; 1(4):96-111.
8) S .T. Deshpande et al, Floating Drug Delivery System: A Novel Approach towords Gastroretentive Drug Delivery System, Research J. Pharma. Dosage Forms and Tech, 2013, 5(4); 191-201.
9) Pakhale NV, Gondkar SB, Saudagar RB, Effervescent Floating Drug Delivery System: A Review, Journal of Drug Delivery and Therapeutics. 2019; 9(3-s):836-838. DOI https://doi.org/10.22270/jddt.v9i3-s.2817
10) Singh LP et al, Floating effervescent Tablet: A Review, JPBMS, 2011; 5(11):1-6.
11) Pawar VK, Shaswat K, Garg G, Awasthi R, Singodia D, Kulkarni GT, Gastroretentive Dosage Forms: A review with special emphasis on floating drug delivery systems, Drug Delivery, 2011; 18(2):97-110.
12) Padhan et al, Flaoting Oral In-situ Gel, A Comprehensive Approach of Gastroretentive Drug Delivery System: A Review, IJPSR, 2019; 10(9):4026-4039.
13) Chowdary KPR, Shankar KR, Teeda V, Floating Drug Delivery Systems: A Review of Recent Research, IRJPAS, 2014; 4(4):14-24.
14) Grover I, Marwah M, Devgan M, Floating Drug Delivery systems: A Novel Approach, Research J. Pharm. and Tech. 2015, 8(4); 490-495.
15) Sah S, Floating Drug Delivery System: Rationale for drug selection, J Pharma Care Health Sys, 2015; 2(4):80.
16) Dua JS et al, A Review: Floating Drug Delivery System (FDDS), World Journal of Pharmaceutical Research, 2016; 5(6):614-633.
17) Lopes CM et al, Overview on gastroretentive drug delivery systems for improving drug bioavailability, International Journal of Pharmaceutics, 2016; 510:144-158.
18) Gupta P et al, Floating Drug Delivery System: A Review, International Journal of Pharma Research & Review, 2015; 4(8):37-44.
19) S. Gopalakrishnan et al, Floating Drug Delivery Systems: A Review, Journal of Pharmaceutical Science and Technology, 2011; 3(2):548-554.
20) Sopyan I et al, A Novel of Floating Tablet Delivery System as A Tool to Enhance Absorbtion of Drug: A Review, Indo J. Pharm, 2020; 2(1):27-33.
21) Kumar M, Kaushik D, An Overview on Various Approaches and Recent Patents on Gastroretentive Drug Delivery System, Recent Patents on Drug Delivery & Formulation, 2018, 12; 84-92.
22) Nettekallu Y et al, A Review on Floating Drug Delivery Systems, Indo Am. J. P. Sci, 2016; 3(6):682-687.
23) Kumari B, Recent Development in Floating Drug Delivery System: A Review, Asian Journal of Pharmacy and Pharmacology, 2018, 4(2); 131-139.
24) Sutar FY et al, A Scientific Review On: Floating Drug Delivery System (FDDS), IJPRS, 2014; 3(3):297-314.
25) Setia M, Kumar K, Teotia D, Gastro-retentive floating beads a new trend of drug delivery system, Journal of Drug Delivery and Therapeutics. 2018; 8(3):169-180. DOI https://doi.org/10.22270/jddt.v8i3.1717
26) Jawale S.K, Bairagi A. S, Jaybhai S, Deshmukh V.K, A Review of Floating Drug Delivery System, 2010; 2(9):40-47.
27) Kamalakkannan et al, Enhancement of Drugs Bioavailability by Floating Drug Delivery System- A Review, International Journal of Drug Delivery, 2011; 3(4):558-570.
28) Ahmed A, Goyal NK, Pramod K. Sharma, Effervescent Floating Drug Delivery System: A Review, Global Journal of Pharmacology, 2014; 8(4):478-485.
29) Chaudhary PK et al, Approaches for Gastroretentive Drug Delivery Systems- A Review, Journal of Drug Delivery and Therapeutics, 2014, 4(3):14-24. DOI https://doi.org/10.22270/jddt.v4i3.834
30) Ghule PN, Deshmukh AS, Mahajan VR, Floating Drug Delivery System (FDDS): An Overview, Research Journal of Pharmaceutical Dosage Forms and Technology, 2014; 6(3):174-182.
31) Ananthakumar R et al, A review on applications of natural polymers in gastroretentive drug delivery system, Drug Invention Today, 2018; 10(3):285-289.
32) Awasthi R, Kulkarni GT, Decades of research in drug targeting to the upper gastrointestinal tract using gastroretention technologies: where do we stand? , Drug Delivery, 2016; 23(2):378-394.
33) Narang et al, An Updated Review On: Floating Drug Delivery System (FDDS), Int J. App Pharm, 2011; 3(1):1-7
34) Khairiya D, Kumar K, A Comprehensive Review On Floating Drug Delivery System: A Novel Drug Delivery System, GJRA, 2019; 8(1):179-183.
35) Arora S et al, Floating Drug Delivery Systems: A Review, AAPS PharmSciTech, 2005; 6(3):E372-E390.
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0). that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).