Impact of Cigarette Smoking on Sperm Parameters of Infertile Men in Center of Algiers (Capital of Algeria)
Abstract
Background : Cigarette smoking has negative effects on male fertility. Toxins from tobacco smoking can potentially affect sperm development and function, with a negative effect on semen parameters. In fact, the components of cigarette smoke pass through the blood-testis barrier and thus induce an alteration of sperm parameters and nucleus quality of the spermatozoa. The aim is to determine a diffence between tobbaco and no tobbaco patient and semen parameters. This article aimed to assess the relationship between smoking and male infertility.
Subject and Methods : this is retrospective study focused on the effects of smoking on semen analyses. 377 men (165 non-smokers, 212 smokers) with infertility for at least 1 year were evaluated between Mars and November 2018, in center of algiers (capital of Algeria). Sperm characteristics (concentration, motility, morphology, and volume) were detemined.
Results: Sperm concentration, percentage motility and morphology were significantly lower in an infertile Smokers group than the infertile Nonsmokers group. We also observed that the infertility duration were significantly increased (p<0.05) in accordance with the age in an infertile Smokers group. Our study shows that cigarette smoking is associated with reduced sperm count and motility.
Conclusions: Our results suggest that cigarette smoking has an overall negative effect on semen parameters. Our study suggests that men should be advised to abstain from smoking in order to improve reproductive outcomes.
Keywords: smoking, semen, male infertility, sperm, humans
Downloads
References
2. Zinaman MJ, Brown CC, Selevan SG, Clegg ED 2000 Semen quality and human fertility: a prospective study with healthy couples. Journal of Andrology . 2015, 21, 145–153.
3. Sharma R, Biedenharn KR, Fedor JM, Agarwal A. Lifestyle factors and reproductive health: taking control of your fertility. Reprod Biol Endocrinol 2013;11:66.
4. Calogero A, Polosa R, Perdichizzi A, et al. Cigarette smoke extract immobilizes human spermatozoa and induces sperm apoptosis. Reprod Biomed. 2009;19: 564–71
5. Zenzes MT. Smoking and reproduction: gene damage to human gametes and embryos. Hum Reprod Update. 2000;6:122–31.
6. Kunzle R, Mueller MD, Hanggi W, Birkhauser MH, Drescher H, Bersinger NA. Semen quality of male smokers and nonsmokers in infertile couples. Fertil Steril. 2003;79:287–91.
7. Al-Matubsi HY, Kanaan RA, Hamdan F, Salim M, Oriquat GA, Al Hanbali OA. Smoking practices in Jordanian people and their impact on semen quality and hormonal levels among adult men. Cent Eur J Public Health. 2011;19:54–9.
8. Ramlau-Hansen CH, Thulstrup AM, Aggerholm AS, Jensen MS, Toft G, Bonde JP. Is smoking a risk factor for decreased semen quality? A cross-sectional analysis. Hum Reprod. 2007; 22(1):188– 188. [PubMed: 16966350]
9. Kunzle R, Mueller MD, Hanggi W, Birkhauser MH, Drescher H, Bersinger NA. Semen quality of male smokers and nonsmokers in infertile couples. Fertil Steril. 2003; 79(2):287–287. [PubMed: 12568836]
10. Merino G, Lira SC, Martinez-Chequer JC. Effects of cigarette smoking on semen characteristics of a population in Mexico. Arch Androl. 1998; 41(1):11–11. [PubMed: 9642454
11. Shiffman S. Tobacco ‘‘chippers’’–individual differences in tobacco dependence. Psychopharmacology (Berl). 1989;97:539–47.
12. Al-Turki HA. Effect of smoking on reproductive hormones and semen parameters of infertile Saudi Arabians. Urol Ann. 2015;7:63–6
13. Mitra A, Chakraborty B, Mukhopadhay D, et al. Effect of smoking on semen quality, FSH, testosterone level, and CAG repeat length in androgen receptor gene of infertile men in an Indian city. Syst Biol Reprod Med. 2012;58:255–62.
14. El-Melegy NT, Ali ME. Apoptotic markers in semen of infertile men: association with cigarette smoking. Int Braz J Urol. 2011;37: 495–506.
15. Joo KJ, Kwon YW, Myung SC, Kim TH. The effects of smoking and alcohol intake on sperm quality: light and transmission electron microscopy findings. J Int Med Res. 2012;40:2327–35.
16. Anifandis G, Bounartzi T, Messini CI, Dafopoulos K, Sotiriou S, Messinis IE. The impact of cigarette smoking and alcohol consumption on sperm parameters and sperm DNA fragmentation (SDF) measured by Halosperm. Arch Gynecol Obstet. 2014;290: 777–82.
17. Agarwal A, Prabakaran SA. Mechanism, measurement, and prevention of oxidative stress in male reproductive physiology. Ind J Exp Biol. 2005; 43:963-974.
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0). that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
.