IMMEDIATE RELEASE TABLET OF ANTIHYPERTENSIVE DRUG OLMESARTAN MEDOXOMILE
Abstract
Olmesartanmedoxomile blocks the vasoconstrictor and aldosterone-secreting effects of angiotensin II by selectively binding to the AT1 angiotensin II receptor. ACEinhibitor is used in treatment of hypertension. Olmesartanmedoxomiletablet have been prepared  by wet granulation method and also by direct compression. Effect of various fillers and disintegrants werealso explored. Microcrystalline cellulose, lactose monohydrate,were used in wet granulation. In order to obtain acceptable productseveral trials wereconducted.And ten different formulations were prepared. Various pharmacopoeial evaluations of the formulations were conducted including weight variation, hardness, disintegrationtime, friability andin-vitro dissolution. Final selection of formulation was done based on pharmaceutical equivalence of development formulation to that of marketed one.
Keywords:
Immediate release tablet, Superdisintegrants,lactose monohydrate,hypertension.DOI
https://doi.org/10.22270/jddt.v3i2.427Published


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