IMMEDIATE RELEASE TABLET OF ANTIHYPERTENSIVE DRUG OLMESARTAN MEDOXOMILE

Authors

  • Mayur V Mahida Department of Pharmaceutics, Jaipur College of Pharmacy, Jaipur (Rajasthan) India
  • M M Gupta Department of Pharmaceutics, Jaipur College of Pharmacy, Jaipur (Rajasthan) India

Abstract

Olmesartanmedoxomile  blocks  the  vasoconstrictor  and  aldosterone-secreting  effects  of  angiotensin  II  by  selectively  binding  to  the  AT1 angiotensin  II  receptor.  ACEinhibitor is used  in treatment  of  hypertension. Olmesartanmedoxomiletablet have been prepared  by  wet  granulation method and also by direct compression. Effect of various fillers and disintegrants  werealso explored. Microcrystalline cellulose, lactose monohydrate,were used in wet granulation. In order to obtain acceptable productseveral  trials  wereconducted.And ten different formulations were prepared.  Various  pharmacopoeial  evaluations  of  the  formulations  were  conducted  including  weight  variation,  hardness,  disintegrationtime, friability  andin-vitro dissolution.  Final  selection of  formulation  was  done  based on pharmaceutical  equivalence  of  development  formulation to  that  of marketed one.

Keywords:

Immediate release tablet, Superdisintegrants,lactose monohydrate,hypertension.

DOI

https://doi.org/10.22270/jddt.v3i2.427

Published

15-03-2013
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How to Cite

1.
Mahida MV, Gupta MM. IMMEDIATE RELEASE TABLET OF ANTIHYPERTENSIVE DRUG OLMESARTAN MEDOXOMILE. J. Drug Delivery Ther. [Internet]. 2013 Mar. 15 [cited 2025 Feb. 9];3(2). Available from: https://jddtonline.info/index.php/jddt/article/view/427

How to Cite

1.
Mahida MV, Gupta MM. IMMEDIATE RELEASE TABLET OF ANTIHYPERTENSIVE DRUG OLMESARTAN MEDOXOMILE. J. Drug Delivery Ther. [Internet]. 2013 Mar. 15 [cited 2025 Feb. 9];3(2). Available from: https://jddtonline.info/index.php/jddt/article/view/427