Evaluation of Antiulcer Activity of Ethanol Extract of Leaves of Lactuca sativa
Abstract
In this modern era, gastrointestinal disorders are the universal problem. Peptic ulcer is one of the major diseases affecting the human population. It develops due to the imbalance between aggressive factors like acid, pepsin, H. pylori and bile salts and defensive factors like mucous, bicarbonate, blood flow, epithelial cell restoration and prostaglandins. The anti-ulcer activity of Ethanol extract of leaves of Lactuca sativa (EELS) was estimated using the experimental models of acute gastric lesions induced by ethanol, pylorus ligation and cold restraint stress in Wistar albino rats. Animals pre-treated with doses of 250 mg/kg, 500 mg/kg of EELS were statistically analyzed and compared to the standard and control group with the parameters like volume of gastric secretion, total acidity and ulcer index. The results suggested that EELS significantly decreased volume of gastric acid secretion, total acidity and ulcer index in comparison with standard drug Omeprazole. EELS shown significant reduction in lesion index, total affected area and percentage of lesion in comparison with control group in Ethanol induced ulcer in experimental models. The gastric mucosal protective effect of EELS is brought by inhibiting the gastric secretion, which shows it may act like a proton pump inhibitor. Thus the present study indicates that EELS has anti-ulcerogenic potency in Ethanol induced, pylorus ligation and cold restraint stress induced ulcers in rats.
Keywords: Antiulcer, ulcer index, cold stress, peptic ulcer, pylorus ligation
Keywords:
Antiulcer, ulcer index, cold stress, peptic ulcer, pylorus ligationDOI
https://doi.org/10.22270/jddt.v10i4.4190References
Akhtar, M.S., Khtar, A.H., Khan, M.A. International Journal of Pharmacognosy1992; 30:97-98.
Tripathi, K.D. Essentials of Medical Pharmacology. Jaypee Brothers Medical Publishers (P) Ltd. New Delhi. 628- 642; 1999.
Peskar BM., Maricic N., Role of prostaglandins in gastroprotection. Digestive Diseases and Sciences 1998; 43:23-9.
Ariyoshi, I., Toshiharu, A., Sugimura, F., Abe, M., Matsuo, Y., Honda T.Recurrence during maintenance therapy with Histamine H2 antagonist in cases of gastric ulcer. Nihon University Journal of Medicine 1986; 28: 69-74.
Borelli F., Izzo AA. The plant kingdom as a source of anti-ulcer remedies, Phytotherapy Research 2000; 14: 581-91.
Satoskar, R.S., Bhandarkar, S.D., Ainapure, S.S. (1999) Pharmacology and Pharmacotherapeutics, 16th edn, popular prakashan, Mumbai; 1999.
Kulkarni, S. Handbook of Experimental Pharmacology. 3rd ed. Vallabh Prakashan, Delhi, Pages 148-150. PMid: 23120157 PMCid: 3450965; 2005.
Nicolle C, Cardinault N, Gueux E, Jaffrelo L, Rock E, Mazur A, et al. Health effect of vegetable-based diet: lettuce consumption improves cholesterol metabolism and antioxidant status in the rat. Clinical Nutrition 2004; 23:605–14.
Araruna K, Carlos B. Anti-inflammatory activities of triterpene lactones from Lactuca sativa. Phytopharmacology 2010; 1:1–6.
Hefnawy TM, Ramadan MF. Protective effects of Lactuca sativa ethanolic extract on carbon tetrachloride induced oxidative damage in rats. Asian Pacific Journal of Tropical Disease. 2013; 3:277–85.
Deshpande SS, Shah GB, Parmar NS. Antiulcer activity of Tephrosia purpurea in rats. Indian Journal of Pharmacology. 2003; 35:168–72.
Kulkarni SK. Hand book of experimental pharmacology. New Delhi: Vallabh Prakashan; pp. 148–50; 1999.
Nie SN, Qian XM, Wu XH, Yang SY, Tang WJ, Xu BH, et al. Role of TFF in healing of stress induced gastric lesions. World Journal of Gastroenterology. 2003; 9:1772–76.
Dwivedi V, Chander BS, Yadav NH. Evaluation of anti-ulcer activity of Clitorea ternatea Leaves (Linn) extract in Wistar rats. Indian Journal of Research in Pharmacy and Biotechnology. 2014; 3:1225–29.
Published
Abstract Display: 705 
PDF Downloads: 765 How to Cite
Issue
Section
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0). that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
How to Cite
.