Formulation and Evaluation of Transdermal Topical Gel of Ibuprofen
Abstract
The present research work is based on the formulation and evaluation of topical gel of Ibuprofen where Carbopol 940 is used as the polymer. Gels were prepared by dispersing the polymers in a mixture of water and glycerol with methyl paraben as the preservative and the varying amount of ibuprofen, being kept under magnetic stirring until the homogeneous dispersion was formed. The dispersion was then neutralized and made viscous by the addition of triethanolamine. The Carbopol gels of Ibuprofen were found to be homogenous with good drug loading. The pH of all the gel formulations was found within the neutral pH range which is compatible with skin. And the viscosity of the formulations was found to be feasible for topical drug delivery. The drug content of the three formulations was found in the range of 87.56% to 90.45% which shows efficient drug loading. Results of In vitro drug release study showed that F5 formulation has better diffusion of drug through egg membrane and hence further permeation studies were carried out through rat epidermis. The compatibility study showed that the major peaks in FTIR spectra of the pure drug were found to be intact in their physical mixture. Hence there is no interaction between drug and Carbopol in their physical mixture. Carbopol can be effectively used as the polymer for topical gel preparation. And F5 formulation containing 0.5 % w/w Carbopol 940 may be effectively used as topical transdermal delivery for Ibuprofen.
Keywords: Ibuprofen, Transdermal Gel, Drug release, Compatibility study
DOI
https://doi.org/10.22270/jddt.v10i2.3902References
Vyas PS, Khar KR, “Drug delivery system”, 2012; 2: 397-399.
Robinso JR, Lee HL, “Controlled drug delivery fundamentals and applications”, 1987; 2: 524-552.
Aqui SY, Ali A, “Matrix type transdermal drug delivery systems of metoprolol tartrate: In vitro characterization” Acta Pharm, 2003; 119-125.
Baselt R, “Disposition of toxic drugs and chemicals in Man,Foster city” Biomedical Publications, 2008; 8: 758–761.
Misra AN, “Controlled and novel drug delivery” CBS Publishers and Distributors, 1997; 107-109.
Singh J, Tripathi KP and Sakia TR, “Effect of penetration enhancers on the in vitro transport of ephedrine through rat skin and human epidermis from matrix based transdermal formulations” Drug Dev Ind Pharm, 1993;1623-1628.
Farra H, Letzig L, Gil M, “Validation of a liquid chromatographic method for the determination of ibuprofen in human plasma” Journal of Chromatography, 2002; 780: 341–348.
Barkin RL, “Topical Nonsteroidal Anti-Inflammatory Drugs: The Importance of Drug, Delivery, and Therapeutic Outcome” American Journal of Therapeutics, 2015; 22:388–407.
Dantas MGB, Reis SA, Damasceno CMD, Rolim LA, Rolim-Neto PJ, Carvalho, FO, Quintans-Junior LJ and Silva JR, “Development and Evaluation of Stability of a Gel Formulation Containing the Monoterpene Borneol” The Scientific World Journal, 2016.
Patel H, Panchal M, Shah S and Vadalia KR, “Formulation and Evaluation of Transdermal Gel of Sildenafil Citrate” International Journal of Pharmaceutical Research & Allied Sciences, 2012;1:103-118.
Ahme SZ, Nahid K, Alaadin A, Mark S, Sarah I, Rahman Z,Cruz C and Muhammad A, “Effect of Isopropyl Myristate on Transdermal Permeation of Testosterone from Carbopol Gel” Journal of Pharmaceutical Sciences, 2017.
Marwa HS, Ghada FM, “Evaluation of Topical Gel Bases Formulated with Various Essential Oils for Antibacterial Activity against Methicillin Resistant Staphylococcus Aureus” Tropical Journal of Pharmaceutical Research, 2013;12: 877-884.
Ujwala A, Modani SH and Singh KH, “Design and Development of Repaglinide Microemulsion Gel for Transdermal Delivery” AAPS PharmSciTech, 2018.
Mohamed A, Amira AM, Mohammed AA and Abdulrhman AO, “An in vivo study of Hypericum perforatum in a niosomal topical drug delivery system” Drug Delivery, 2018; 25: 417-425.
Jangdey MS, Gupta A and Saraf S: Fabrication, “In-vitro characterization, and enhanced in-vivo evaluation of carbopol-based nanoemulsion gel of apigenin for UV-induced skin carcinoma” Drug Delivery, 2017; 24:1026-1036.
Ali DF, Ahmed AA, Hamza MY and Mohamed MI, “Microemulsion for Topical Delivery of Fenoprofen Calcium: In-vitro and In-vivo Evaluation Journal of Liposome Research”, 2017; 1532-2394.
Pawar J, Narkhede R, Amin, P and Tawde V, ‘Design and Evaluation of Topical Diclofenac Sodium Gel Using Hot Melt Extrusion Technology as a Continuous Manufacturing Process” AAPS Pharm SciTech, 2017; 5:1530-9932.
Kalita B, Das MK, Sarma M and Deka A, “Sustained Anti-inflammatory Effect of Resveratrol-Phospholipid Complex Embedded Polymeric Patch” AAPS PharmSciTech, 2016.
Okur NU, Caglar E, Muhammet DA and Karasulu YK, “Preparation and evaluation of novel microemulsion-based hydrogels for dermal delivery of benzocaine” Pharmaceutical Development and Technology, 2017; 22: 500-510.
Nanda S, Saroha K and Sharma B, “Formulation, Evaluation And Optimization Of Transdermal Gel Of Ketorolac Tromethamine Using Face Centred Central Composite Design” International Journal of Pharmacy and Pharmaceutical Sciences, 2014; 6:0975-1491.
Ahmed MG, “Formulation and Evaluation Of Transdermal Gel Of Lornoxicam In Combination With Chemical Enhancers” International Journal Of Research In Pharmacy and Chemistry, 2014; 4:996-1003.
Acharya A, Dhakal P, and Khadka D, “Formulation and Evaluation of Transdermal Gel of Lornoxicam and its Delivery by Passive and Inotophoresis Method: A Comparative Study” International Journal of Pharmaceutical Sciences and Research, 2017.
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