ANTI-INFLAMMATORY ACTIVITY OF ROOT OF DECALEPSIS HAMILTONII

Abstract

Powdered root of Decalepsis hamiltonii was used to evaluate the acute & chronic anti-inflammatory activities in rodents. Albino rats of either sex were divided into 4 sets (n=24). Set A, B, C was used for evaluating the anti inflammatory activity after inducing acute inflammation with carrageenan, bradykinin and 5HT respectively while Set D was used for evaluating the anti inflammatory activity after inducing chronic inflammation with formaldehyde. Each set was subdivided into four groups I-IV (n=6). In all the sets, GR I served as control (receiving gum acacia only), GR II received root extract of D. hamiltonii at the dose of 250mg /kg, GR III received Phenylbutazone 50 mg / Kg, and GR IV received Dexamethasone 0.5 mg / Kg. There was inflammatory inhibition of 35.55% in carrageenan induced, 42.62% in 5HT induced and 36.62% in bradykinin induced acute inflammatory models. In the chronic Inflammatory model, a progressive inhibition of 36.84% (3^rd day), 36.45% (5th day), 51.45% (7^th day) and 66.39% (13^th day) was observed with study compound. The efficacy was comparable to the standard drugs. To summarize, we can say that Decalepsis hamiltonii is an anti-inflammatory and anti arthritic agent that may block histamine and serotonin path way. It may be an effective alternative to NSAIDs and corticosteroids in inflammatory disorders.

KeyWord:Antiinflammatoryactivities,D.hamiltonii, rodents