DEVELOPMENT, CHARACTERIZATION & STABILIZATION OF POORLY WATER SOLUBLE DRUGS UTILIZING SOLID DISPERSION TECHNIQUES BY USING Î’ - CYCLODEXTRIN

Authors

  • Rakesh Singh Institue of Pharmaceutical Science and Research Centre; Bhagwant University, Ajmer
  • A K Jain Institue of Pharmaceutical Science and Research Centre; Bhagwant University, Ajmer

Abstract

Telmisartan (TLM) is an angiotensin II receptor antagonist used in the treatment of hypertension. According to BCS (biopharmaceutical classification system) Telmisartan belongs to class II drug, and it is practically insoluble in water and it shows low dissolution profile and poor absorption. The present study is to improve the solubility of Telmisartan by forming complexation with β- CD by using four convenient methods viz physical mixing method, kneading method, and solvent evaporation fusion method at different molar ratios of 1:1, dissolution studies were carried out in pH 7.4 phosphate buffer. The cyclodextrin complexes formulated by employing 1:1 (drug: complexing agent) with kneading technique showed higher drug release.

Keywords: Telmisartan, inclusion complex, β - cyclodextrin, physical, kneading, solvent evaporation & fusion method.

DOI

https://doi.org/10.22270/jddt.v3i1.378

Published

2013-01-14
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How to Cite

1.
Singh R, Jain AK. DEVELOPMENT, CHARACTERIZATION & STABILIZATION OF POORLY WATER SOLUBLE DRUGS UTILIZING SOLID DISPERSION TECHNIQUES BY USING Î’ - CYCLODEXTRIN. J. Drug Delivery Ther. [Internet]. 2013 Jan. 14 [cited 2026 Jan. 21];3(1). Available from: https://jddtonline.info/index.php/jddt/article/view/378

Issue

Vol. 3 No. 1 (2013): Volume 3, Issue 1, Jan-Feb, 2013

Section

Research

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How to Cite

1.
Singh R, Jain AK. DEVELOPMENT, CHARACTERIZATION & STABILIZATION OF POORLY WATER SOLUBLE DRUGS UTILIZING SOLID DISPERSION TECHNIQUES BY USING Î’ - CYCLODEXTRIN. J. Drug Delivery Ther. [Internet]. 2013 Jan. 14 [cited 2026 Jan. 21];3(1). Available from: https://jddtonline.info/index.php/jddt/article/view/378
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