STUDY OF VARIOUS PARAMETERS EFFECTING IN FORMULATION OF WATER SOLUBLE METFORMIN HYDROCHLORIDE ETHYL-CELLULOSE MICRO-PARTICLES
Abstract
Water soluble Metformin hydrochloride microparticles was being prepared by ethyl-cellulose in liquid paraffin medium with variable rotating speed, different drug polymer ratio and different concentration of the surface-active agent. Percentage yield, bulk density, tapped density, Carr’s compressibility index, Hausner ratio, Angle of repose of prepared microparticles was determined. The release study of the water soluble Metformin hydrochloride microparticles also performed. From the findings of the present investigations, it was evident that the selected materials and sustained release property offering very promising area in the field of research.
Key words: Metformin hydrochloride, Ethyl-cellulose, Micro-particles, In-vitro drug release study, Bioavailability.
DOI
https://doi.org/10.22270/jddt.v3i2.376
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