Fabrication and Evaluation of Floating Mucoadhesive Tablets of Cefpodoxime Proxetil Using Factorial Design

Abstract

The present research work aims to fabricate and optimize gastroretentive floating mucoadhesive tablets of Cefpodoxime Proxetil, so as to remain in the gastric region for appropriate hours and hence significantly prolong the gastric residence time of drugs which improve bioavailability. Floating-Mucoadhesive tablets of Cefpodoxime Proxetil were prepared by direct compression method using various polymers such as HPMC K 200 M, Carbopol 940P. Sodium Bicarbonate & Citric acid was incorporated as a gas-generating agents and HPMC K 200 M, Carbopol 940 P was incorporated as Mucoadhesive agent. Optimization study was carried out by using 3² factorial design. The concentration of polymers was considered as independent variables whereas Floating lag time,Swelling Index, Mucoadhesive Strength, of the tablets were utilized as dependent variables. The floating- Mucoadhesive tablets were evaluated for weight variation, hardness, thickness, friability, drug content, in-vitro buoyancy study, and in-vitro and ex-vivo Mucoadhesive studies, swelling index and in-vitro dissolution studies. The study reveals the significant effect of the amount of polymers on Floating lag time, Swelling Index, Mucoadhesive Strength of the tablets. FTIR, DSC study indicates no drug-excipients interaction in the prepared formulations. The prepared tablets exhibited satisfactory physico-chemical characteristics. All prepared batches shown good in-vitro buoyancy studies and Mucoadhesion studies. The In-vitro dissolution profiles of optimized floating- Mucoadhesive formulation of Cefpodoxime Proxetil were found to sustained the drug release up to 12 hrs and release can be extended for longer period over 12 hrs by increasing the concentration of polymers. The best result from optimized batches is of AT5 which gives floating lag time 21±2, Mucoadhesive strength 16.60 gm & drug release 98.65% in 12 hrs. Floating- Mucoadhesive tablet were prepared and could be a promising approach to deliver  Cefpodoxime Proxetil with improved gastric residence time which improve bioavailability &  effective in the management of the bacterial infection.

Keywords: Cefpodoxime Proxetil, , HPMC K200M, Carbopol 940P,Floating-Mucoadhesive, factorial design