SAM-e AND ITS THERAPEUTIC PRINCIPLES

Abstract

S-Adenosylmethionine (SAM-e) which is an well-known super nutrient in countries like Europe , Italy, but unfortunately it is unknown in many countries, which is mainly available as nutrient supplement, same though it is not a completely  new compound but can be found in our tissues performing trans methylation reaction(methyl donor) with  Iupac name as  [(3S)-3-amino-3-carboxypropyl]({[(2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl})methylsulfanium .SAM-e stands first among all other drugs in treating depression, cirrhosis, osteoarthritis, Alzheimer disease, Though it was discovered in 1952 it self but it does not came in to lime light, much more studies are to be conducted to evaluate it uses and even the way it works can be inspiring to us in preparing its derivatives. Alcoholic cirrhosis patients when given SAM-e miraculously cured just by increasing the regeneration efficacy of the liver, this article mainly discuss the uses of SAMe and the principle mechanism involved in it.