Development and Characterization of Mucoadhesive Nanoparticles of Topiramate for Nasal Administration

Abstract

Nasal drug delivery has been recognized as a promising route for delivery of therapeutic compounds including biopharmaceuticals. It has been demonstrated that absorption of drugs can enhance by using absorption enhancers or increasing the drug residence time in the nasal cavity. Mucoadhesive polymers can serve both functions. The residence time in the nasal cavity is considerably increased for nanoparticles compared to solutions. Topiramate (TPM) is used alone or with other medications to prevent and control seizures (epilepsy). This medication is also used to prevent migraine headaches and decrease how often you get them. TPM will not treat a migraine headache once it occurs. The purpose of the present study was to prepare and evaluate mucoadhesive chitosan nanoparticles of TPM for the nasal administration by ionic gelation method. Nanoparticles were subjected to various characterization techniques such as FTIR, particle size, scanning electron microscopy (SEM), drug entrapment efficiency and zeta potential are also determined for the developed formulations. The nanoparticles exhibited mucoadhesive properties, which diminished with increasing drug content. The nanoparticles with a particle size range between 45and 62nm exhibited excellent mucoadhesive properties. Stability study at various storage temperature was also done in which the prepared formulation showed an improved stability. The zeta potential of the best chitosan preparation (F4) was found to be -35.5mV, which confirms the stability of prepared nanosuspension. Mucoadhesive chitosan nanoparticles can be a promising carrier for nasal delivery of TPM found to have high encapsulation efficiency and predetermined in vitro release profile.

Keywords: Nasal drug delivery, Topiramate, Nanoparticles, ionic gelation method, Migraine headache