COMPRESSIONAL PROPERTIES OF PARACETAMOL TABLET FORMULATIONS CONTAINING MODIFIED STARCH, POLYVINYLPYRROLIDONE AND MAIZE STARCH BP AS BINDERS
Abstract
The compressional properties of paracetamol tablet formulations containing modified starch (acid hydrolysed), Polyvinylpyrrolidone and maize starch as binders have been investigated. Paracetamol granules obtained by wet massing at varying binder concentrations were compacted using a hydraulic press at different tabletting pressures (28.31-141.56 MNm-2). Density measurements and the compression equations of Heckel and Kawakita were used as assessment parameters where the following variables PY, DA, DB, Do, Pk, and DI were investigated. Formulations containing modified starch showed a slower onset of plastic deformation due to a high mean yield pressure while that of PVP showed the highest onset of plastic deformation. Maize starch BP had the lowest PK value indicating the highest total plastic deformation occurring during compression while modified starch had the highest PK value owing to a lesser total plastic deformation showing that there is a correlation between the compression equations of Heckel and Kawakita as assessment parameters and that modified cassava starch could be useful as a binder in paracetamol tablet formulations to produce tablets with desired compressional properties for particular purposes.
Keywords: Modified starch, Polyvinylpyrrolidone(PVP), Heckel equation, Kawakita equation, plastic deformation.
DOI
https://doi.org/10.22270/jddt.v3i1.353
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