Topical Anti-inflammatory evaluation of new hydrazone: 4-chloro-3-nitrobenzylidene) isonicotinohydrazide
Topical Anti-inflammatory evaluation
The anti-inflammatory effects of the investigated compounds; Isoniazid, hydrazone, and Indomethacin were evaluated in this study. The experiment was performed using xylene induced topical ear edema method in mice model, at the dose of (0.5 mg/ear). Results showed that the compounds; Isoniazid, hydrazone, and Indomethacin exerted 85, 90 and 89% of inhibition percentages, respectively. The effect of hydrazone was statistically similar to the effect of indomethacin which is a standard anti-inflammatory drug.
Keywords: inflammation, hydrazone, ear edema, topical.
2. Nagi MN, Mansour MA (2000). Protective Effect of Thymoquinone against Doxorubicin induced Cardiotoxicity in Rats: A Possible Mechanism of Protection. Pharmacological Research. 41: 283–289.
3. Serhan C.N., Ward P.A. and Gilroy D.W. (2010). Fundamentals of inflammation. Cambridge University Press. p. 13-14.
4. Dorward D.A., Lucas C.D., Rossi A.G., Haslett C. and Dhaliwal K. (2012). Imaging inflammation: molecular strategies to visualize key components of the inflammatory cascade, from initiation to resolu-tion. Pharmacology and Therapeutics. 135(2), 182-199.
5. Weill B, Batteux F, Dhainaut J (2003). Immunopathologie et réactions inflammatoires. ds, De Boeck Université (Paris), pp: 12-23.
6. Delaporte R H, Sarragiotto M H, Takemura O S, S´anchezc G M, Filho B P D, Nakamura C V (2004). Evaluation of the antioedematogenic, free radical scavenging and antimicrobial activities of aerial parts of Tillandsia streptocarpa Baker Bromeliaceae. Journal of Ethnopharmacology, 95, 229–233.
7. Okoli CO, Akah P A, Nwafor S V, Anisiobi A I, Ibegbunam I N, Erojikwe O (2007) Anti-inflammatory activity of hexane leaf extract of Aspilia africana C.D. Adams. Journal of Ethnopharmacology, 109, 219–225.
8. Rotelli A E, Guardia T, Juárez A O, de la Rocha N E, Pelzer L E (2003). Comparative study of flavonoids in experimental models of inflammation. Pharmacological Research, 48, 601-606.
9. Li H, Lu X, Zhang S, Lu M, Liu H (2008). Anti_Inflammatory Activity of Polysaccharide from Pholiota nameko. Biochemistry, 73, 669-675.
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